Mesh fixation using novel bio-adhesive coating compared to tack fixation for IPOM hernia repair: in vivo evaluation in a porcine model

Yehuda, Amir Ben; Nyska, Abraham; Szold, Amir

doi:10.1007/s00464-019-06806-x

Cited by 7 publications

(7 citation statements)

References 65 publications

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“…In the present experimental study, we used one of these tissue adhesives, namely, an n-hexyl CA monomer, as a control to compare its biological and mechanical behavior with that of self-fixing meshes, which constitute another very good alternative for atraumatic abdominal prosthetic fixation. This group includes meshes equipped with systems that fix the mesh to the receptor tissue either through “grip” type devices [ 14 , 34 ] or through adhesive hydrogels included with the meshes [ 13 , 16 , 27 , 28 , 35 , 36 ].…”

Section: Discussionmentioning

confidence: 99%

Self-adhesive hydrogel meshes reduce tissue incorporation and mechanical behavior versus microgrips self-fixation: a preclinical study

Benito-Martínez

Rodrı́guez

García-Moreno

et al. 2022

Hernia

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Purpose Atraumatic mesh fixation for abdominal hernia repair has been developed to avoid the disadvantages of classical fixation with sutures, which is considered a cause of chronic pain and discomfort. This study was designed to analyze, in the short and medium term, the biological and mechanical behavior of two self-fixing meshes compared to that of a polypropylene (PP) mesh fixed with a cyanoacrylate (CA) tissue adhesive. Methods Partial abdominal wall defects (6 × 4 cm) were created in New Zealand rabbits (n = 36) and repaired using a self-adhesive hydrogel mesh (Adhesix™), a self-gripping mesh (ProGrip™) or a PP mesh fixed with CA (Surgipro™ CA). After 14 and 90 days, the host tissue incorporation, macrophage response and biomechanical strength were examined. Results At 14 and 90 days, the ProGrip and Surgipro CA meshes showed good host tissue incorporation; however, the Adhesix implants presented poor integration, seroma formation and a higher degree of shrinkage. The Adhesix hydrogel was completely reabsorbed at 14 days, whereas ProGrip microhooks were observed at all study times. The macrophage response was higher in the ProGrip and Surgipro CA groups at 14 and 90 days, respectively, and decreased over time. At 90 days, the ProGrip implants showed the highest tensile strength values and the Adhesix implants showed the highest failure stretch. Conclusion Meshes with mechanical microgrip self-fixation (ProGrip) show better biological and mechanical behavior than those with adhesive hydrogel (Adhesix) in a preclinical model of abdominal hernia repair in rabbits.

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Section: Discussionmentioning

confidence: 99%

Self-adhesive hydrogel meshes reduce tissue incorporation and mechanical behavior versus microgrips self-fixation: a preclinical study

Benito-Martínez

Rodrı́guez

García-Moreno

et al. 2022

Hernia

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“…For example, self-adhesive hernia meshes can enhance the ease of attachment and mitigate postsurgical adverse effects. 427 Furthermore, bioadhesive patches can be used to provide mechanical support to infarcted heart tissue. 428 For instance, a viscoelastic bioadhesive patch based on an ionically cross-linked starch gel was developed to achieve tissuemimetic mechanical properties, leading to superior tissue remodeling in a rat model.…”

Section: Bioadhesive Mechanical Supportmentioning

confidence: 99%

“…It finds applications in various procedures, such as repairing hernias and reinforcing heart tissue damaged by myocardial infarction. , The traditional use of sutures or tacks to fix mechanical support structures can lead to secondary complications including pain, postsurgical adhesions, and dislodgement. − Bioadhesive mechanical supports are favorable alternatives. For example, self-adhesive hernia meshes can enhance the ease of attachment and mitigate postsurgical adverse effects . Furthermore, bioadhesive patches can be used to provide mechanical support to infarcted heart tissue .…”

Section: Nontraditional Applications Of Bioadhesivesmentioning

confidence: 99%

Bioadhesive Technology Platforms

Wu,

Zhao

2023

Chem. Rev.

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Bioadhesives have emerged as transformative and versatile tools in healthcare, offering the ability to attach tissues with ease and minimal damage. These materials present numerous opportunities for tissue repair and biomedical device integration, creating a broad landscape of applications that have captivated clinical and scientific interest alike. However, fully unlocking their potential requires multifaceted design strategies involving optimal adhesion, suitable biological interactions, and efficient signal communication. In this Review, we delve into these pivotal aspects of bioadhesive design, highlight the latest advances in their biomedical applications, and identify potential opportunities that lie ahead for bioadhesives as multifunctional technology platforms.

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“…To improve mesh fixation to the host tissue, materials have been developed that have systems such as grips [ 82 ] or adhesives [ 83 , 84 ] to anchor the mesh. The objective of these designs has been to avoid the trauma of the use of sutures or tacks [ 85 ].…”

Section: Classic Polymer Biomaterials and Hernia Repairmentioning

confidence: 99%

Polymer Hernia Repair Materials: Adapting to Patient Needs and Surgical Techniques

et al. 2021

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Biomaterials and their applications are perhaps among the most dynamic areas of research within the field of biomedicine. Any advance in this topic translates to an improved quality of life for recipient patients. One application of a biomaterial is the repair of an abdominal wall defect whether congenital or acquired. In the great majority of cases requiring surgery, the defect takes the form of a hernia. Over the past few years, biomaterials designed with this purpose in mind have been gradually evolving in parallel with new developments in the different surgical techniques. In consequence, the classic polymer prosthetic materials have been the starting point for structural modifications or new prototypes that have always strived to accommodate patients’ needs. This evolving process has pursued both improvements in the wound repair process depending on the implant interface in the host and in the material’s mechanical properties at the repair site. This last factor is important considering that this site—the abdominal wall—is a dynamic structure subjected to considerable mechanical demands. This review aims to provide a narrative overview of the different biomaterials that have been gradually introduced over the years, along with their modifications as new surgical techniques have unfolded.

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Mesh fixation using novel bio-adhesive coating compared to tack fixation for IPOM hernia repair: in vivo evaluation in a porcine model

Cited by 7 publications

References 65 publications

Self-adhesive hydrogel meshes reduce tissue incorporation and mechanical behavior versus microgrips self-fixation: a preclinical study

Self-adhesive hydrogel meshes reduce tissue incorporation and mechanical behavior versus microgrips self-fixation: a preclinical study

Bioadhesive Technology Platforms

Polymer Hernia Repair Materials: Adapting to Patient Needs and Surgical Techniques

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