Mesoporous bioactive glass: ideal material for higher uptake and well sustained release of ibuprofen

Zhang, J; Qu, Fengyu; Lin, Huiming; Wu, Xiang; Jiang, Jingjie

doi:10.1179/1433075x11y.0000000044

Cited by 6 publications

(6 citation statements)

References 26 publications

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“…As shown in Figure 8, three Fe-MBG/C composite scaffolds had smooth surfaces before soaking in SBF solutions. However, it can be observed that a large amount of microparticles was deposited on the surfaces of three Fe-MBG/C composite scaffolds after soaking in SBF solutions for 3 days, which is similar to the previously reported formation of apatite particles on the MBG powders and scaffolds [3][4][5][6][7][14][15][16][17][18][19][20][21][22][23][24][25]. The results indicated that the magnetic Fe-MBG/C composite scaffolds are bioactive according to Kokubo's view [44].…”

Section: Resultssupporting

confidence: 88%

“…Mesoporous bioactive glass (MBG), as a bioactive material, has drawn growing interest in bone regeneration in recent years [1,2]. As a result of its high specific surface area, large pore volume, and mesoporous structure, MBG exhibits the enhanced bone-forming bioactivity, degradation and drug delivery properties, compared to the conventional bioactive glass (BG) [3][4][5][6][7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

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Preparation and Characterization of Magnetic Mesoporous Bioactive Glass/Carbon Composite Scaffolds

Zhu

Zhang

Zhou

et al. 2013

Journal of Chemistry

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The magnetic Fe-MBG/C composite scaffolds with enhanced mechanical strength and multifunctionality have been successfully prepared. The study showed that the Fe-MBG/C composite scaffolds with the porosity of ca. 80% had interconnected macropores (200–500 µm) and mesopores (3.7–4.4 nm) and significantly enhanced the compressive strength compared to the pure MBG scaffolds. Importantly, the Fe-MBG/C composite scaffolds exhibited good bioactivity and sustained drug release property. At the same time, the Fe-MBG/C composite scaffolds could generate heat to raise the temperature of surrounding environment in an alternating magnetic field due to their superparamagnetic behavior. Therefore, the magnetic Fe-MBG/C composite scaffolds could form a multifunctional platform with bone regeneration, magnetic hyperthermia, and local drug delivery and have more potential for use in the regeneration of the critical-sized bone defects caused by bone tumors.

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Section: Resultssupporting

confidence: 88%

Section: Introductionmentioning

confidence: 99%

Preparation and Characterization of Magnetic Mesoporous Bioactive Glass/Carbon Composite Scaffolds

Zhu

Zhang

Zhou

et al. 2013

Journal of Chemistry

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“…Recently, Zhang et al 11 synthesized the mesoporous bioactive glass (MBG) and the mesoporous silica (MS) using an evaporation‐induced self‐assembly process and ibuprofen was loaded into both matrices. The MBG showed higher drug loading capacity (46 %) compared to the MS (28 %) due to higher surface area and pore volume.…”

Section: Drug Controlled Release Bone Treatments and Bone Regenermentioning

confidence: 99%

“…The inevitable interaction between the drug and the silica matrix is a surface phenomenon 5. When the unmodified silica‐based materials are used, the appearance of initial burst release of the drug is quite obvious, and in some cases, an irregular and unexpected pattern of drug release is also observed 5, 11, 34, 35. The silica‐based materials modified by the biopolymers or surfactants showed some degree of control in their initial burst release of the drugs with controllable release pattern in an extended period of time 5, 16, 26, 36–39.…”

Section: Future Perspectivesmentioning

confidence: 99%

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The Silica‐based Formulations for Drug Delivery, Bone Treatment, and Bone Regeneration

Chowdhury

2016

ChemBioEng Reviews

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The utilization of the silica-based materials in biomedical applications is evolving at a rapid pace with attentions mostly devoted to the ordered mesoporous silica nanoparticles (MSNs). However, apart from the ordered-MSNs, a range of other silicabased materials have been extensively applied in the controlled release (CR) of drugs, bone treatments, and bone regeneration, but have gained less attention. This article presents an overview on the recent research advancements of the silica-based materials, i.e., silica xerogels, silica microspheres, silica hybrids, silica microcapsule particles, silica ceramics, silica bioactive glasses, and silica beads which are mainly used in CR of drugs, bone disease treatments, and bone regeneration. The in vitro and in vivo biological evaluations on these silica-based materials for antibacterial properties, osteoblast cell activities, osteogenetic performances, cell adhesion and proliferation, bio-mineralization, and material degradation are discussed. The effect of morphology or surface modifications and addition of bone morphogenetic proteins to the silica-based formulations are illustrated.

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Mesoporous silica nanoparticles: Their potential as drug delivery carriers and nanoscavengers in Alzheimer's and Parkinson's diseases

Attia¹,

Yahya²,

Monaem³

et al. 2023

Saudi Pharmaceutical Journal

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Mesoporous bioactive glass: ideal material for higher uptake and well sustained release of ibuprofen

Cited by 6 publications

References 26 publications

Preparation and Characterization of Magnetic Mesoporous Bioactive Glass/Carbon Composite Scaffolds

Preparation and Characterization of Magnetic Mesoporous Bioactive Glass/Carbon Composite Scaffolds

The Silica‐based Formulations for Drug Delivery, Bone Treatment, and Bone Regeneration

Mesoporous silica nanoparticles: Their potential as drug delivery carriers and nanoscavengers in Alzheimer's and Parkinson's diseases

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