Mesoporous bioactive glass nanoparticles doped with magnesium: drug delivery and acellular in vitro bioactivity

Tabia, Zakaria; Mabrouk, Khalil El; Bricha, Meriame; Nouneh, Khalid

doi:10.1039/c9ra01133a

Cited by 106 publications

(58 citation statements)

References 60 publications

(83 reference statements)

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“…Adding to this, the mesoporous nanoparticle form of bioactive glass has the capacity to intracellular deliver therapeutic molecules (drugs, growth factors, or genes) [ 16 ]. Some of the recent studies have reported that mesoporous bioactive glass nanomaterials and their composites/hybrids could demonstrate the capacity for delivering drugs and genes, as well as releasing bioactive ions [ [18] , [19] , [20] , [21] , [22] , [23] , [24] , [25] , [26] , [27] , [28] , [29] , [30] ].…”

Section: Introductionmentioning

confidence: 99%

Nanotherapeutics for regeneration of degenerated tissue infected by bacteria through the multiple delivery of bioactive ions and growth factor with antibacterial/angiogenic and osteogenic/odontogenic capacity

El‐Fiqi

Mandakhbayar

et al. 2021

Bioactive Materials

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Therapeutic options are quite limited in clinics for the successful repair of infected/degenerated tissues. Although the prevalent treatment is the complete removal of the whole infected tissue, this leads to a loss of tissue function and serious complications. Herein the dental pulp infection, as one of the most common dental problems, was selected as a clinically relevant case to regenerate using a multifunctional nanotherapeutic approach. For this, a mesoporous bioactive glass nano-delivery system incorporating silicate, calcium, and copper as well as loading epidermal growth factor (EGF) was designed to provide antibacterial/pro-angiogenic and osteo/odontogenic multiple therapeutic effects. Amine-functionalized Cu-doped bioactive glass nanospheres (Cu-BGn) were prepared to be 50–60 nm in size, mesoporous, positive-charged and bone-bioactive. The Cu-BGn could release bioactive ions (copper, calcium and silicate ions) with therapeutically-effective doses. The Cu-BGn treatment to human umbilical vein endothelial cells (HUVEC) led to significant enhancement of the migration, tubule formation and expression of angiogenic gene (e.g. vascular endothelial growth factor, VEGF). Furthermore, the EGF-loaded Cu-BGn (EGF@Cu-BGn) showed pro-angiogenic effects with antibacterial activity against E. faecalis , a pathogen commonly involved in the pulp infection. Of note, under the co-culture condition of HUVEC with E. faecalis , the secretion of VEGF was up-regulated. In addition, the osteo/odontogenic stimulation of the EGF@Cu-BGn was evidenced with human dental pulp stem cells. The local administration of the EGF@Cu-BGn in a rat molar tooth defect infected with E. faecalis revealed significant in vivo regenerative capacity, highlighting the nanotherapeutic uses of the multifunctional nanoparticles for regenerating infected/damaged hard tissues.

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Section: Introductionmentioning

confidence: 99%

Nanotherapeutics for regeneration of degenerated tissue infected by bacteria through the multiple delivery of bioactive ions and growth factor with antibacterial/angiogenic and osteogenic/odontogenic capacity

El‐Fiqi

Mandakhbayar

et al. 2021

Bioactive Materials

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“…Arepalli et al reported that bioactive glasses in the system (46.10-x)%SiO2-26.9%CaO-24.40%Na2O-xMgO-2.6%P2O5 (where 0≤x≤3 mol %) are bioactive and biocompatible both in vitro and in vivo 14,24 . It is well reported that magnesium slows down the crystallization of the apatite layer 16,17 , however, in this work we report the formation of an apatitelike phase after 1 h of soaking in SBF as it can be seen in Figure 3. Additionally, the growth of apatite layer continues to occur as it can be observed from the pattern of SNCMP glass after 30 d of immersion in SBF solution.…”

Section: Resultsmentioning

confidence: 45%

“…It was found that the incorporation of MgO in the bioactive glass accelerates the early stages of the precipitation of HAC layer 15 . However, some studies have reported that MgO slows down the precipitation rate of HAC 16,17 . Tabia et al have shown that there is no crystallization of HAC layer when magnesium attaint 10 mol % in the ternary bioactive glass 85SiO2-(15-x)CaO-xMgO (where x = 0, 1, 3, 5 and 10) 16 .…”

Section: Introductionmentioning

confidence: 99%

Physicochemical and in vitro bioactivity studies of bioactive glasses in the SiO2-CaO-MgO-P2O5, SiO2-Na2O-CaO-P2O5 and SiO2-Na2O-CaO-MgO-P2O5 systems

et al. 2020

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Glasses in the quaternary and quinary system SiO2-CaO-MgO-P2O5 (SCMP), SiO2-Na2O-CaO-P2O5 (SNCP) and SiO2-Na2O-CaO-MgO-P2O5 (SNCMP), have been prepared by using the sol-gel technique. Investigations of structural and bioactive properties of these glasses have been undertaken by using X-ray diffraction (XRD), Fourier Transform Infrared Spectroscopy (FTIR), Scanning Electron Microscopy (SEM) and Energy Dispersive X-ray Spectroscopy (EDS). The in vitro bioactivity was assessed by determining the changes in surface morphology and composition after soaking in simulated body fluid (SBF) for up to 30 days at 37°C. X-ray diffraction patterns indicated the formation of hydroxycarbonated apatite layer (HCA) after only one hour for SNCMP glass and after four days for SCMP and SNCP glasses. Furthermore, observed bands of FTIR spectra confirmed the growth of HCA layer during in vitro test.Moreover, the dissolution rate has been investigated using energy-dispersive X-ray spectroscopy. The observed EDS patterns confirmed the growth of HCA layer on all samples surfaces during in vitro analysis. On the one hand, we report the existence of Na2Ca2Si3O9 (that couple good mechanical strength with satisfactory biodegradability) as a single crystalline phase in the SNCP glass when calcined at 600°C. On the other hand, we have noticed that the coexistence of magnesium and sodium both enhanced the dissolution rate and hindered the crystallization in the SNCMP glass at 600°C.

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“…Tabia et al [192] fabricated the Mg-doped bioactive glass nanoparticles (BG-NPs) through the sol-gel route. They loaded amoxicillin to the synthesized BG-NPs and investigated their drug release behavior.…”

Section: The State-of-the-art Of Composites Containing Zn and Mg In Dmentioning

confidence: 99%

An overview of the development of composites containing Mg and Zn for drug delivery

Niazvand¹,

Cheshmi

Zand

et al. 2020

jcc

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Mesoporous bioactive glass nanoparticles doped with magnesium: drug delivery and acellular in vitro bioactivity

Abstract: The effects of the magnesium doping of binary glass (Si–Ca) on particle texture, on the biomineralization process in simulated body fluid (SBF) as well as on drug loading and release were examined.

Cited by 106 publications

References 60 publications

Nanotherapeutics for regeneration of degenerated tissue infected by bacteria through the multiple delivery of bioactive ions and growth factor with antibacterial/angiogenic and osteogenic/odontogenic capacity

Nanotherapeutics for regeneration of degenerated tissue infected by bacteria through the multiple delivery of bioactive ions and growth factor with antibacterial/angiogenic and osteogenic/odontogenic capacity

Physicochemical and in vitro bioactivity studies of bioactive glasses in the SiO2-CaO-MgO-P2O5, SiO2-Na2O-CaO-P2O5 and SiO2-Na2O-CaO-MgO-P2O5 systems

An overview of the development of composites containing Mg and Zn for drug delivery

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