Mesoporous M41S materials in capillary gas chromatography

Raimondo, M.; Pérez, G.; Sinibaldi, M.; Stefanis, Adriana De; Tomlinson, A. A. G.

doi:10.1039/a702849k

Cited by 81 publications

(42 citation statements)

References 2 publications

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“…Chromatography is among the applications of MTS, which has received considerable attention. Mesostructured silicas have been proposed as stationary phases for capillary GC [8], size exclusion chromatography (SEC) [9][10][11], normal-phase HPLC [12,13], chiral HPLC [14,15], RP-HPLC [16,17], and protein separation by RP-HPLC [18]. Their high specific surface area, high pore volume, and adjustable pore size, in the range of 2-10 nm were expected to improve the retention capacity, the column permeability, and the molecular selectivity, respectively, during the separation processes.…”

Section: Introductionmentioning

confidence: 99%

Spherical ordered mesoporous silicas and silica monoliths as stationary phases for liquid chromatography

Galarneau¹,

Iapichella

Brunel

et al. 2006

J of Separation Science

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Ordered mesoporous silicas such as micelle-templated silicas (MTS) feature unique textural properties in addition to their high surface area (approximately 1000 m2/g): narrow mesopore size distributions and controlled pore connectivity. These characteristics are highly relevant to chromatographic applications for resistance to mass transfer, which has never been studied in chromatography because of the absence of model materials such as MTS. Their synthesis is based on unique self-assembly processes between surfactants and silica. In order to take advantage of the perfectly adjustable texture of MTS in chromatographic applications, their particle morphology has to be tailored at the micrometer scale. We developed a synthesis strategy to control the particle morphology of MTS using the concept of pseudomorphic transformation. Pseudomorphism was recognized in the mineral world to gain a mineral that presents a morphology not related to its crystallographic symmetry group. Pseudomorphic transformations have been applied to amorphous spherical silica particles usually used in chromatography as stationary phases to produce MTS with the same morphology, using alkaline solution to dissolve progressively and locally silica and reprecipitate it around surfactant micelles into ordered MTS structures. Spherical beads of MTS with hexagonal and cubic symmetries have been synthesized and successfully used in HPLC in fast separation processes. MTS with a highly connected structure (cubic symmetry), uniform pores with a diameter larger than 6 nm in the form of particles of 5 microm could compete with monolithic silica columns. Monolithic columns are receiving strong interest and represent a milestone in the area of fast separation. Their synthesis is a sol-gel process based on phase separation between silica and water, which is assisted by the presence of polymers. The control of the synthesis of monolithic silica has been systematically explored. Because of unresolved yet cladding problems to evaluate the resulting macromonoliths in HPLC, micromonoliths were synthesized into fused-silica capillaries and evaluated by nano-LC and CEC. Only CEC allows to gain high column efficiencies in fast separation processes. Capillary silica monolithic columns represent attractive alternatives for miniaturization processes (lab-on-a chip) using CEC.

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Section: Introductionmentioning

confidence: 99%

Spherical ordered mesoporous silicas and silica monoliths as stationary phases for liquid chromatography

Galarneau¹,

Iapichella

Brunel

et al. 2006

J of Separation Science

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show abstract

“…MCM-41 silica belongs to this type of ordered mesoporous silica, which have been widely used as stationary phases for different chromatographic modes, including size-exlusion chromatography [8],7,9], RP HPLC [10], chiral HPLC [11], and capillary gas chromatography [6]. Compared to MCM-41 silica, MSU-X materials generally exhibit a less ordered but regular wormhole porous structure.…”

Section: Introductionmentioning

confidence: 99%

“…The unique properties of these silica materials are their high surface areas, extremely narrow pore size distribution, perfectly adjustable pore size, and the presence of silanol groups, which are promising for chromatographic separations. Recently, such application in GC and HPLC has been reported [6,7]. In CEC, however, highly ordered mesoporous silica was, up till now, not investigated in terms of its performance as supports in spite of their numerous advantages.…”

mentioning

confidence: 99%

Large‐pore mesoporous SBA‐15 silica particles with submicrometer size as stationary phases for high‐speed CEC separation

et al. 2006

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A new mesoporous sphere-like SBA-15 silica was synthesized and evaluated in terms of its suitability as stationary phases for CEC. The unique and attractive properties of the silica particle are its submicrometer particle size of 400 nm and highly ordered cylindrical mesopores with uniform pore size of 12 nm running along the same direction. The bare silica particles with submicrometer size have been successfully employed for the normal-phase electrochromatographic separation of polar compounds with high efficiency (e.g., 210,000 for thiourea), which is matched well with its submicrometer particle size. The Van Deemeter plot showed the hindrance to mass transfer because of the existence of pore structure. The lowest plate height of 2.0 microm was obtained at the linear velocity of 1.1 mm/s. On the other hand, because of the relatively high linear velocity (e.g., 4.0 mm/s) can be generated, high-speed separation of neutral compounds, anilines, and basic pharmaceuticals in CEC with C18-modified SBA-15 silica as stationary phases was achieved within 36, 60, and 34 s, respectively.

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“…Among applications that can take advantage of the unique properties of mesostructured silicas produced by the selfassembly of surfactants and silicates, chromatography has received considerable attention and represents the most demanding application in terms of size and shape control. Mesostructured silicas have been proposed as stationary phases for capillary gas chromatography, [8] size-exclusion chromatography (SEC), [9][10][11] normal-phase high-performance liquid chromatography (HPLC), [12,13] chiral HPLC, [14,15] reverse-phase HPLC (RP-HPLC), [5,16] and protein separation by RP-HPLC. [17] It was anticipated that their high specific surface areas, high pore volumes, and adjustable pore sizes in the range 2-10 nm would improve, respectively, the retention capacity, the column permeability, and the molecular selectivity in the separation processes.…”

Section: Introductionmentioning

confidence: 99%

Controlling the Morphology of Mesostructured Silicas by Pseudomorphic Transformation: a Route Towards Applications

et al. 2006

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Mesoporous M41S materials in capillary gas chromatography

Cited by 81 publications

References 2 publications

Spherical ordered mesoporous silicas and silica monoliths as stationary phases for liquid chromatography

Spherical ordered mesoporous silicas and silica monoliths as stationary phases for liquid chromatography

Large‐pore mesoporous SBA‐15 silica particles with submicrometer size as stationary phases for high‐speed CEC separation

Controlling the Morphology of Mesostructured Silicas by Pseudomorphic Transformation: a Route Towards Applications

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