Mesoporous Materials as Elements of Modern Drug Delivery Systems for Anti-Inflammatory Agents: A Review of Recent Achievements

Moritz, Michał; Geszke-Moritz, Małgorzata

doi:10.3390/pharmaceutics14081542

Cited by 7 publications

(4 citation statements)

References 167 publications

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“…M41S are applied as delivery agents because they have tunable particle size and morphology, uniform and tunable pore size, high surface area and pore volume, facile surface functionalization, stable physicochemical properties, and thermal stability [108]. Moreover, some mesoporous silica materials are characterized by biodegradability and biocompatibility [109]. Cytometry assays revealed that synthesized silica has no cytotoxicity against human peripheral blood mononuclear cells.…”

Section: -Applications Of M41s Materialsmentioning

confidence: 99%

Synthesis, Characterizations, and Recent Applications of the Silica-based Mobil Composition of Mesoporous Material: A Review

Kurji,

Mujtaba,

Abbas

2023

IJCPE

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Silica-based mesoporous materials are a class of porous materials with unique characteristics such as ordered pore structure, large surface area, and large pore volume. This review covers the different types of porous material (zeolite and mesoporous) and the physical properties of mesoporous materials that make them valuable in industry. Mesoporous materials can be divided into two groups: silica-based mesoporous materials and non-silica-based mesoporous materials. The most well-known family of silica-based mesoporous materials is the Mesoporous Molecular Sieves family, which attracts attention because of its beneficial properties. The family includes three members that are differentiated based on their pore arrangement. In this review, the major applications of the Mobil Mesoporous Molecular Sieves family, such as catalysts, adsorbents, and drug delivery agents, have been surveyed. Furthermore, the synthesis of the Mesoporous Molecular Sieves materials, the silica sources, the importance of templates, and the mechanisms of the synthesis are discussed herein. Members of this material family are characterized by many physicochemical properties that are closely related to their high silica content, crystalline structure, and pore arrangement. Commonly, the members of this family have large surface areas, high pore volumes, small pore sizes, and narrow and uniform particle size distributions. These properties enable numerous industrial applications and opportunities for scientific studies to further develop existing materials or manufacture new ones.

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Section: -Applications Of M41s Materialsmentioning

confidence: 99%

Synthesis, Characterizations, and Recent Applications of the Silica-based Mobil Composition of Mesoporous Material: A Review

Kurji,

Mujtaba,

Abbas

2023

IJCPE

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“…3 Treatment for central nervous system disease 3.1 Nanocarriers for nose-to-brain drug delivery Drug delivery systems deliver a certain dose to a target site in the body and maintain the drug concentration in that area at a dose appropriate for the duration of the treatment (Moritz and Geszke-Moritz, 2022). Nanocarriers are loaded with drugs to achieve this purpose and to deliver drugs to the brain efficiently, where they are selectively released to the target site via transport to specific cells and tissues, avoiding side effects caused by systemic exposure; nanocarriers also help drugs cross the BBB and provide neuroprotection (Figure 2) (Wen et al, 2021).…”

Section: Airway Hazardsmentioning

confidence: 99%

Transnasal-brain delivery of nanomedicines for neurodegenerative diseases

Wang

Liu³

et al. 2023

Front. Drug Deliv.

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Neurodegenerative diseases (NDs) have become a serious global health problem as the population ages. Traditionally, treatment strategies for NDs have included oral and intravenous administration; however, the blood–brain barrier (BBB) can prevent drugs from reaching the brain, rendering the treatment incomplete and the effect unsatisfactory. Additionally, the prolonged or excessive use of drugs that can cross the BBB can damage liver and kidney function. Recent studies have shown that nose-to-brain drug delivery can noninvasively bypass the BBB, allowing drugs to enter the brain through the olfactory or trigeminal nerve pathways; additionally, nanoparticle carriers can enhance drug delivery. This review introduces drug carrier nanoparticles for nose-to-brain delivery systems, compares the advantages and disadvantages of different nanoparticles, and discusses the factors influencing nose-to-brain nanomedicine delivery and enhancement strategies. We also summarize nose-to-brain delivery and nanomedicines for treating NDs, the current challenges of this approach, and the future promise of nanomedicine-based ND treatment.

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“…The discovery of silica nanoparticles helped to overcome the limitations of currently used nanomaterials, such as poor solubility and bioavailability. It provoked its use in porous glass and disordered silica gels for drug-delivery applications [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

Mesoporous Silica-Based Nanoplatforms Are Theranostic Agents for the Treatment of Inflammatory Disorders

et al. 2023

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Complete recovery from infection, sepsis, injury, or trauma requires a vigorous response called inflammation. Inflammatory responses are essential in balancing tissue homeostasis to protect the tissue or resolve harmful stimuli and initiate the healing process. Identifying pathologically important inflammatory stimuli is important for a better understanding of the immune pathways, mechanisms of inflammatory diseases and organ dysfunctions, and inflammatory biomarkers and for developing therapeutic targets for inflammatory diseases. Nanoparticles are an efficient medical tool for diagnosing, preventing, and treating various diseases due to their interactions with biological molecules. Nanoparticles are unique in diagnosis and therapy in that they do not affect the surroundings or show toxicity. Modern medicine has undergone further development with nanoscale materials providing advanced experimentation, clinical use, and applications. Nanoparticle use in imaging, drug delivery, and treatment is growing rapidly owing to their spectacular accuracy, bioavailability, and cellular permeability. Mesoporous silica nanoparticles (MSNs) play a significant role in nano therapy with several advantages such as easy synthesis, loading, controllability, bioavailability over various surfaces, functionalization, and biocompatibility. MSNs can be used as theranostics in immune-modulatory nano systems to diagnose and treat inflammatory diseases. The application of MSNs in the preparation of drug-delivery systems has been steadily increasing in recent decades. Several preclinical studies suggest that an MSN-mediated drug-delivery system could aid in treating inflammatory diseases. This review explains the role of nanoparticles in medicine, synthesis, and functional properties of mesoporous silica nanoparticles and their therapeutic role against various inflammatory diseases.

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Mesoporous Materials as Elements of Modern Drug Delivery Systems for Anti-Inflammatory Agents: A Review of Recent Achievements

Cited by 7 publications

References 167 publications

Synthesis, Characterizations, and Recent Applications of the Silica-based Mobil Composition of Mesoporous Material: A Review

Synthesis, Characterizations, and Recent Applications of the Silica-based Mobil Composition of Mesoporous Material: A Review

Transnasal-brain delivery of nanomedicines for neurodegenerative diseases

Mesoporous Silica-Based Nanoplatforms Are Theranostic Agents for the Treatment of Inflammatory Disorders

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