Mesoporous NaYbF4@NaGdF4 core-shell up-conversion nanoparticles for targeted drug delivery and multimodal imaging

Zhou, Liangjun; Zheng, Xiaopeng; Gu, Zhanjun; Yin, Wenyan; Zhang, Xiao; Ruan, Longfei; Yang, Yanbo; Hu, Zhongbo; Zhao, Yuliang

doi:10.1016/j.biomaterials.2014.05.051

Cited by 103 publications

(56 citation statements)

References 57 publications

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“…Under the 980 nm laser irradiation, PEI‐UCNPs dispersion exhibits bright green UCL (inset in Figure d, right) and the corresponding UCL spectrum of PEI‐UCNPs was shown in Figure d. The three major peaks centered at 521, 540, and 654 nm come from 2 H 11/2 → 4 I 15/2 , 4 S 3/2 → 4 I 15/2 , and 4 F 9/2 → 4 I 15/2 electron transition of Er 3+ ions, respectively . In addition, since the zeta potential ( ζ ) is an important parameter to measure the stability of a system, the zeta potential tests of UCNPs dispersed in water and nutrient solutions were carried out.…”

Section: Resultsmentioning

confidence: 98%

Phytotoxicity, Translocation, and Biotransformation of NaYF₄Upconversion Nanoparticles in a Soybean Plant

Yin

Zhou

et al. 2015

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The increasing uses of rare-earth-doped upconversion nanoparticles (UCNPs) have obviously caused many concerns about their potential toxicology on live organisms. In addition, the UCNPs can be released into the environment, then transported into edible crop plants, and finally entered into food chain. Here, the soybean is chosen as a model plant to study the subchronic phytotoxicity, translocation, and biotransformation of NaYF4 UCNPs. The incubation with UCNPs at a relative low concentration of 10 μg mL(-1) leads to growth promotion for the roots and stems, while concentration exceeding 50 μg mL(-1) brings concentration-dependent inhibition. Upconversion luminescence imaging and scanning electron microscope characterization show that the UCNPs can be absorbed by roots and parts of the adsorbed UCNPs are then transported through vessels to stems and leaves. The near-edge X-ray absorption fine structure spectra reveal that the adsorbed NaYF4 nanoparticles are relatively stable during a 10 d incubation. Energy-dispersive X-ray spectrum further indicates that a small amount of NaYF4 is dissolved/digested and can transform into Y-phosphate clusters in roots.

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Section: Resultsmentioning

confidence: 98%

Phytotoxicity, Translocation, and Biotransformation of NaYF₄Upconversion Nanoparticles in a Soybean Plant

Yin

Zhou

et al. 2015

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“…Then, the flow cytometer was used to analyze the fluorescence intensity of the cells collected. Cell-up taking efficiency was calculated according to the previous study as follows: 45 cellular uptake efficiency= (the number of PLMSNs-labeled tumor cells)/(the total number of tumor cells counted) ×100%.…”

Section: Methodsmentioning

confidence: 99%

Enhanced cell uptake of fluorescent drug-loaded nanoparticles via an implantable photothermal fibrous patch for more effective cancer cell killing

Ren

et al. 2017

J. Mater. Chem. B

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Great efforts have been devoted to effective delivery of therapeutics into cells for cancer therapy. The exploration of nanoparticle based drug delivery systems (DDSs) faces daunting challenges in low efficacy of intracellular delivery. Herein, a localized drug delivery device consisting of photoluminescent mesoporous silica nanoparticles (PLMSNs) and photothermal fibrous matrix was investigated. Specifically, PLMSNs modified with a pH-sensitive polydopamine (PDA) ‘gatekeeper’ served as a doxorubicin (DOX) carrier and could release DOX once the PLMSNs were up-taken by the cancer cells. The PLMSNs were electrostatically assembled on the surface of electrospun biodegradable poly(ε-caprolactone)/gelatin fibrous mesh incorporated with photothermal carbon nanoparticles (CNPs), leading to an implantable patch used as localized delivery platform. Comparing to free particulate DDSs, this implantable composite patch device was found to significantly enable superior cell up-taking effect and consequently enhance in-vitro therapeutic efficacy against tumor cells. Namely, under near infrared irradiation, the photothermal effect of CNPs in the implantable patch weakens the electrostatic interaction between the PLMSNs and poly(ε-caprolactone)/gelatin/CNP fibrous mesh, resulting in the controlled release of the PLMSNs and subsequent internalization into the tumor cells for more effective cancer cell killing. This implantable therapeutic device may therefore inspire another way of developing localized cancer therapy.

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“…Absorption of water in the near-infrared light region and schematic design of Nd 3+ -sensitized upconversion process through core-shell structural engineering: NaYF 4 :Yb/Er/Nd@NaYF 4 :Nd [94], NaYbF 4 :Nd@ Na(Yb,Gd)F 4 :Er@NaGdF 4 [95], NaGdF 4 :Yb/Er@NaGdF 4 :Nd/Yb [97], NaGdF 4 :Nd@NaYF 4 @NaGdF 4 :Nd/Yb/Er@ NaYF 4 [98], NaYF 4 : Yb/Er@NaYF 4 :Yb@NaNdF 4 :Yb [99]. the magnetic shell, a series of multifunctional nanocomposites such as NaYbF 4 :Tm 3+ /NaGdF 4 , NaYF 4 : Yb/Tm@NaLuF 4 @NaYF 4 @NaGdF 4 , NaYbF 4 :Er 3+ @ NaGdF 4 were prepared [71,105,106], which showed excellent multimodal imaging capacities. Although core-shell approach mentioned above can integrate individual function into one nanosystem, their multistep synthesis procedures are usually complicated and time consuming.…”

Section: Ln-based Ucnps For Multimodal Cancer Imagingmentioning

confidence: 99%

Multimodal Cancer Imaging Using Lanthanide-Based Upconversion Nanoparticles

Yang

Lin

2015

Nanomedicine (Lond.)

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Multimodal nanoprobes that integrate different imaging modalities in one nano-system could offer synergistic effect over any modality alone to satisfy the higher requirements on the efficiency and accuracy for clinical diagnosis and medical research. Upconversion nanoparticles (UCNPs), particularly lanthanide (Ln)-based NPs have been regarded as an ideal building block for constructing multimodal bioprobes due to their fascinating properties. In this review, we first summarize recent advances in the optimizations of existing UCNPs. In particular, we highlight the applications of Ln-based UCNPs for multimodal cancer imaging in vitro and in vivo. The explorations of UCNPs-based multimodal nanoprobes for targeting diagnosis and imaging-guided therapeutics are also presented. Finally, the challenges and perspectives of Ln-based UCNPs in this rapid growing field are discussed.

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Mesoporous NaYbF4@NaGdF4 core-shell up-conversion nanoparticles for targeted drug delivery and multimodal imaging

Cited by 103 publications

References 57 publications

Phytotoxicity, Translocation, and Biotransformation of NaYF₄Upconversion Nanoparticles in a Soybean Plant

Phytotoxicity, Translocation, and Biotransformation of NaYF₄Upconversion Nanoparticles in a Soybean Plant

Enhanced cell uptake of fluorescent drug-loaded nanoparticles via an implantable photothermal fibrous patch for more effective cancer cell killing

Multimodal Cancer Imaging Using Lanthanide-Based Upconversion Nanoparticles

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Mesoporous NaYbF4@NaGdF4 core-shell up-conversion nanoparticles for targeted drug delivery and multimodal imaging

Cited by 103 publications

References 57 publications

Phytotoxicity, Translocation, and Biotransformation of NaYF4Upconversion Nanoparticles in a Soybean Plant

Phytotoxicity, Translocation, and Biotransformation of NaYF4Upconversion Nanoparticles in a Soybean Plant

Enhanced cell uptake of fluorescent drug-loaded nanoparticles via an implantable photothermal fibrous patch for more effective cancer cell killing

Multimodal Cancer Imaging Using Lanthanide-Based Upconversion Nanoparticles

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Phytotoxicity, Translocation, and Biotransformation of NaYF₄Upconversion Nanoparticles in a Soybean Plant

Phytotoxicity, Translocation, and Biotransformation of NaYF₄Upconversion Nanoparticles in a Soybean Plant