Mesoporous particle-based microcontainers for intranasal delivery of imidazopyridine drugs

Марченко, И. В.; Bоrodinа, Tatyana N.; Trushina, Daria B.; Rassokhina, Irina V.; Volkova, Yu. A.; Ширинян, Валерий З.; Заварзин, И. В.; Gogin, A. A.; Букреева, Т. В.

doi:10.1080/02652048.2019.1571642

Cited by 16 publications

(9 citation statements)

References 36 publications

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“…In addition, intranasal administration directs the preparation directly to the bronchial tree without the first pass effect and the possible potential loss of genome copies of rAAV vectors in the body (42)(43)(44)(45)(46)(47)(48)(49). Our study indicated that transduction efficiency is influenced by the vector, promoter and route of administration as has also been shown by Belur et al (64) who have demonstrated that the CAG promoter is more effective (64).…”

Section: (A and C) Results Show The Transduction Efficiency Of The Rasupporting

confidence: 77%

Mosaic Recombinant Adeno-associated Virus Vector rAAV/DJ/CAG for Targeted Gene Delivery to Melanoma Cells Metastasized to the Lung

et al. 2020

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Background/Aim: Patients with metastasized melanoma have limited treatment options and poor diagnosis. Therefore, the development of treatments requires a new therapeutic approach, of which gene therapy using rAAV vectors can be proposed. The aim of the study was to examine the efficiency of the rAAV vector to transduce mouse melanoma cells both in vitro and in vivo. Materials and Methods: Different rAAV serotypes encoding GFP under the control of both chicken beta-actin and cytomegalovirus promoters were used in the experiments. Intranasal, intraperitoneal, intravenous and intratumoral pathways of administration of rAAV vectors were tested using quantitative-PCR and immunohistochemical staining. Results: The highest transduction efficiency in metastatic cells in vivo was observed 7 days after intranasal administration of a 10 10 gc/0.03 ml dose of rAAV/DJ-CAG. Conclusion: Melanoma gene therapy based on rAAV vectors is a possible treatment option. Melanoma is a tumor that derives from pigment cellsmelanocytes, which develop from the neural tissue of integuments. The most common starting point of melanoma is the skin, but it may also be formed within the mucous membranes of the gastrointestinal tract or in the eyeball. It is a cancer with a high potential for metastasis (1, 2). Despite the progress in anti-cancer treatment, the number of deaths due to metastatic melanoma is still increasing and from the beginning of 2019 circa 7,000 patients in the USA died of it (1). Its aggressiveness causes as much as 90% of deaths among all skin cancers (3). The median survival of patients with melanoma who have distant metastases is shorter than 1 year (4). In the initial stage, the disease is curable, but unfortunately in the advanced stage, when metastasis occurs, it is practically incurable (5). The treatment, which has so far been proposed for the advanced stage, does not provide the desired benefit and the survival of these patients remains unsatisfactory. For instance, the annual survival rate after treatment with targeted therapy for the dual BRAF/MEK mutation is only about 50-60% (4, 6). Therefore, one of the future therapeutic approaches in the treatment of metastatic melanoma can be gene therapy using rAAV vectors, especially with the use of hybrid serotypes, which can achieve high efficiency of gene delivery (7-9). AAV viruses are non-pathogenic, small (approx. 25 nm in diameter) and infect both dividing and non-dividing cells. A distinguishing trait of rAAV is also the occurrence of various serotypes, which are characterized by strong tropism to selected cell types, making them ideal candidates for gene therapy (10). rAAV viruses have become increasingly popular in clinical trials (11, 12). In recent years, two pharmaceutical products using rAAV vectors-Glybera (13) and Luxturna (14) have been registered. Recent studies conducted on hybrid/mosaic serotypes have shown a greater transduction efficiency and are more heterogeneous, both in cellular and tissue specificity (15). The new rAAV vectors are created by a num...

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Section: (A and C) Results Show The Transduction Efficiency Of The Rasupporting

confidence: 77%

Mosaic Recombinant Adeno-associated Virus Vector rAAV/DJ/CAG for Targeted Gene Delivery to Melanoma Cells Metastasized to the Lung

et al. 2020

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“…The addition of polyelectrolyte multilayers can improve the adhesion of the carriers while achieving higher encapsulation efficiency, and finally achieve a higher nasal delivery effect. For example, Marchenko et al [ 268 ] adsorbed polyelectrolyte multilayers on mesoporous CCPs carriers loaded with imidazopyridines (anxiolytic hypnotics) and visualized the carriers after intranasal administration using X-ray microtomography. Tomography images of the cross-section of nasal turbinate showed that a certain amount of formulation was remained after 1 h of administration.…”

Section: Application Of Caco 3 and Alginate Carriersmentioning

confidence: 99%

Hard, Soft, and Hard-and-Soft Drug Delivery Carriers Based on CaCO3 and Alginate Biomaterials: Synthesis, Properties, Pharmaceutical Applications

et al. 2022

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Because free therapeutic drug molecules often have adverse effects on normal tissues, deliver scanty drug concentrations and exhibit a potentially low efficacy at pathological sites, various drug carriers have been developed for preclinical and clinical trials. Their physicochemical and toxicological properties are the subject of extensive research. Inorganic calcium carbonate particles are promising candidates as drug delivery carriers owning to their hardness, porous internal structure, high surface area, distinctive pH-sensitivity, low degradability, etc, while soft organic alginate hydrogels are also widely used because of their special advantages such as a high hydration, bio-adhesiveness, and non-antigenicity. Here, we review these two distinct substances as well as hybrid structures encompassing both types of carriers. Methods of their synthesis, fundamental properties and mechanisms of formation, and their respective applications are described. Furthermore, we summarize and compare similarities versus differences taking into account unique advantages and disadvantages of these drug delivery carriers. Moreover, rational combination of both carrier types due to their performance complementarity (yin-&yang properties: in general, yin is referred to for definiteness as hard, and yang is broadly taken as soft) is proposed to be used in the so-called hybrid carriers endowing them with even more advanced properties envisioned to be attractive for designing new drug delivery systems.

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“…The variation in capsule internal structure is dependent on both the porosity of the template, as well as the size of the biopolyelectrolytes utilised for multilayer coating [62]. Templates may be categorized as porous, such as carbonates (i.e., calcium [63,64] and manganese [65,66] carbonates), mesoporous silica [67][68][69], and, potentially, calcium phosphate [70], or non-porous templates, such as polystyrene latex [71,72] and melamine formaldehyde [73]. Biological entities (e.g., erythrocytes [74,75] or bacteria (Escherichia coli (further E. Coli) for instance [76,77])) are also utilised as templates.…”

Section: The Classification Of Sacraficial Templates and Issues Of Biocompatabilitymentioning

confidence: 99%

Biopolymer-Based Multilayer Capsules and Beads Made via Templating: Advantages, Hurdles and Perspectives

Vikulina

Campbell

2021

Nanomaterials

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One of the undeniable trends in modern bioengineering and nanotechnology is the use of various biomolecules, primarily of a polymeric nature, for the design and formulation of novel functional materials for controlled and targeted drug delivery, bioimaging and theranostics, tissue engineering, and other bioapplications. Biocompatibility, biodegradability, the possibility of replicating natural cellular microenvironments, and the minimal toxicity typical of biogenic polymers are features that have secured a growing interest in them as the building blocks for biomaterials of the fourth generation. Many recent studies showed the promise of the hard-templating approach for the fabrication of nano- and microparticles utilizing biopolymers. This review covers these studies, bringing together up-to-date knowledge on biopolymer-based multilayer capsules and beads, critically assessing the progress made in this field of research, and outlining the current challenges and perspectives of these architectures. According to the classification of the templates, the review sequentially considers biopolymer structures templated on non-porous particles, porous particles, and crystal drugs. Opportunities for the functionalization of biopolymer-based capsules to tailor them toward specific bioapplications is highlighted in a separate section.

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Mesoporous particle-based microcontainers for intranasal delivery of imidazopyridine drugs

Cited by 16 publications

References 36 publications

Mosaic Recombinant Adeno-associated Virus Vector rAAV/DJ/CAG for Targeted Gene Delivery to Melanoma Cells Metastasized to the Lung

Mosaic Recombinant Adeno-associated Virus Vector rAAV/DJ/CAG for Targeted Gene Delivery to Melanoma Cells Metastasized to the Lung

Hard, Soft, and Hard-and-Soft Drug Delivery Carriers Based on CaCO3 and Alginate Biomaterials: Synthesis, Properties, Pharmaceutical Applications

Biopolymer-Based Multilayer Capsules and Beads Made via Templating: Advantages, Hurdles and Perspectives

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