Mesoporous silica-based dosage forms improve bioavailability of poorly soluble drugs in pigs: case example fenofibrate

Abstract

The substantial improvements in bioavailability of fenofibrate from the SLC-based formulations confirm the ability of this formulation strategy to overcome the dissolution and solubility limitations, further raising the prospects of a future commercially available SLC-based formulation.

Lipophilicity and hydrophobicity considerations in bio-enabling oral formulations approaches – a PEARRL review

“…Mesoporous silica can be ordered or non‐ordered . The former include structures such as SBA‐15 and MCM‐41, whilst the latter include novel, proprietary excipients manufactured by drug delivery specialists, such as the excipients Parteck SLC (Merck Millipore) and Neusilin (Fuji Chemical) . Such systems have a wide range of applications, including: tissue engineering, catalysis, chromatography, adsorbents in environmental modelling and drug delivery systems for poorly soluble APIs .…”

“…Such systems have a wide range of applications, including: tissue engineering, catalysis, chromatography, adsorbents in environmental modelling and drug delivery systems for poorly soluble APIs . For the latter, it has been widely reported that mesoporous silica can act as a solubility enhancer by ‘trapping’ API in non‐crystalline form within the mesoporous network …”

Approaches to increase mechanistic understanding and aid in the selection of precipitation inhibitors for supersaturating formulations – a PEARRL review

“…Although this has been covered extensively in the literature, it is beyond the scope of this review. The interested reader is referred to a number of recent papers that study the effect of PI selection on in vivo performance of supersaturating formulation …”

“…These approaches can involve modifying the chemical form of an API for example with (1) salt formation, (2) co‐crystals or (3) prodrugs . Or, alternatively, formulation approaches such as (4) solvents, co‐solvents and lipids; (5) micelle systems; (6) particle size reduction; (7) complexation; and (8) solid amorphous dispersions, produced by techniques such as hot melt extrusions (HMEs), spray‐dried dispersions (SDDs), co‐precipitates or mesoporous silica …”

Solubility Enhancement of Glibenclamide Using Mesoporous Silica

“…Adsorption onto mesoporous silica has demonstrated considerable potential in enhancing the solubility of poorly soluble drugs [5]. The drugs can exist in an amorphous or molecularly dispersed state on the surface of mesoporous silica, thus displaying higher apparent solubility and dissolution compared to the crystalline substance [6,7].…”