Mesoporous Silica Nanoparticles‐Based Nanoplatforms: Basic Construction, Current State, and Emerging Applications in Anticancer Therapeutics

Abstract

In recent years, researchers are developing novel nanoparticles for diagnostic applications using imaging techniques and for therapeutic purposes through drug delivery techniques. The unique physical and chemical properties of mesoporous silica nanoparticles (MSNs) make it possible to integrate a variety of commonly used therapeutic and imaging agents to construct a multimodal synergistic anticancer drug delivery system. Herein, recent advances in MSNs synthesis for drug delivery and smart response applications are reviewed. First, synthetic strategies for the fabrication of ordered MSNs, hollow MSNs, core-shell structured MSNs, dendritic MSNs, and biodegradable MSNs are outlined. Then, the recent research progress in designing functional MSN materials with various controlled release mechanisms in anticancer therapy is discussed, and new properties are introduced to suggest the latest design requirements as drug delivery materials. The review also highlights significant achievements in bioimaging using MSNs and their multifunctional counterparts as delivery vehicles. Finally, personal views on key directions for future work in this area are presented.

WITHDRAWN: Polypeptide-coated 5-FU/ICG co-delivery vehicle MSNs for cancer treatment with chemo/photothermal/photodynamic simultaneous therapy

“…Various nanomaterials, such as hydrogels and nanoparticles, as nanodrug-delivery systems, have been thoroughly studied in the treatment of tumor animal models, and good therapeutic effects have been achieved [27][28][29][30][31] . Among the various nanomaterials mentioned above, mesoporous silica nanoparticles (MSNs), as a multifunctional nanoplatforms, exhibit excellent performance in cancer diagnosis and therapy [32][33][34] . MSNs have versatile loading capacity for various exogenous organic molecules, biological macromolecules, and even nanoparticles, due to their adjustable pore size and porosity, large surface area and customized surface functionalization [35][36] .…”

New insights into nanosystems for non-small-cell lung cancer: diagnosis and treatment

“…6C) usually possess a diameter ranging from 50 nm to 200 nm with tightly packed mesopores of size in a range of 3-4 nm. [97][98][99] MSNs are composed of silicon dioxide and are used widely in applications including synthetic processes, medical diagnosis, and therapy due to their high surface area, tuneable pore size, huge loading capacity, and tailored mesoporous structure. Moreover, the outward surface can be functionalized with ''molecular gates", permitting cargo delivery to be triggered by external stimuli such as specic pH, enzymes, and lasers of peculiar wavelengths.…”

Therapeutic Delivery Potential of Covalent Organic Framework (COF): Intuition from Theoretical Calculations

“…As a result, pharmaceutical delivery systems are among the most emerging fields for human health care and constitute a rapidly expanding domain of biomedical materials research. [22] Therefore, finding acceptable non-toxic carriers that are efficient for drug delivery to the body is a critical challenge in the field of drug delivery. Until recently, several methodologies for bioapplications, such as organic polymers and inorganic porous materials, have been investigated.…”