Mesoporous silica nanoparticles functionalized with a dialkoxide diorganotin(IV) compound: In search of more selective systems against cancer cells

Díaz-García, Diana; Sommerová, Lucia; Martisova, Andrea; Skoupilová, Hana; Prashar, Sanjiv; Vaculovič, Tomáš; Kanický, Viktor; Hierro, Isabel del; Hrstka, Roman; Gómez‐Ruiz, Santiago

doi:10.1016/j.micromeso.2020.110154

Cited by 28 publications

(23 citation statements)

References 46 publications

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“…Thus, those materials that have been reacted with 10% FA (MSN-AP-FA-Sn or MSU-2-AP-FA-Sn) presented higher Sn% (with values of about 7.6% and 6.1%, respectively, Table 2 ) compared with those which were reacted with 25% FA (MSN-AP-FA25-Sn or MSU-2-AP-FA25-Sn with functionalization of 5.7% and 5.9% Sn, respectively). Incorporation of the metal complex in the modified systems (MSN-AP-FA-Sn or MSU-2-AP-FA-Sn, MSN-AP-FA-Sn or MSU-2-AP-FA-Sn) was comparable to [ 26 , 27 , 33 , 34 ], if not somewhat higher [ 18 , 20 , 21 ] than, those found for some other systems based on metallodrug-functionalized silica published previously.…”

Section: Resultsmentioning

confidence: 50%

“…Considering that most of the studied systems do not bear any potential targeting molecule to detect and potentiate the active and selective transport of the therapeutic species to the cancer cell line, an enhanced permeability and retention (EPR) effect was considered to be responsible for their slight selectivity towards cancer cell lines (in comparison with normal cell lines) [ 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 ]. Nevertheless, very recent reports have studied the possibility of including a folate fragment for a more effective targeting of cancer cells, which has been partially achieved both in vitro [ 33 ] and in vivo [ 34 ] when using organotin(IV)-functionalized mesoporous silica nanoparticles. Using this strategy of introducing folate fragments, an increase in the selectivity of functionalized-nanostructured silica systems has been achieved using a wide variety of organic approved drugs; however, the biological mechanism of action, including the receptor study of these systems, has still not been elucidated [ 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 ].…”

Section: Introductionmentioning

confidence: 99%

“…As the number of reports of folate-containing metallodrug-functionalized mesoporous silica nanomaterials is very low and limited to the previous studies of our team with tin(IV) derivatives [ 33 , 34 ] and other therapeutic gold(III) compounds [ 48 ], a detailed study was proposed to determine some biological aspects related to the use of these kinds of fragments in cancer chemotherapy in vitro. In general, the folate receptor is a recognised biomarker for tumour cells, usually enabling improvement in cancer cell uptake and potential delivery of the drugs inside the cells [ 49 ].…”

Section: Introductionmentioning

confidence: 99%

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Role of Folic Acid in the Therapeutic Action of Nanostructured Porous Silica Functionalized with Organotin(IV) Compounds against Different Cancer Cell Lines

et al. 2020

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The synthesis, characterization and cytotoxic activity against different cancer cell lines of various mesoporous silica-based materials containing folate targeting moieties and a cytotoxic fragment based on a triphenyltin(IV) derivative have been studied. Two different mesoporous nanostructured silica systems have been used: firstly, micronic silica particles of the MSU-2 type and, secondly, mesoporous silica nanoparticles (MSNs) of about 80 nm. Both series of materials have been characterized by different methods, such as powder X-ray diffraction, X-ray fluorescence, absorption spectroscopy and microscopy. In addition, these systems have been tested against four different cancer cell lines, namely, OVCAR-3, DLD-1, A2780 and A431, in order to observe if the size of the silica-based systems and the quantity of incorporated folic acid influence their cytotoxic action. The results show that the materials are more active when the quantity of folic acid is higher, especially in those cells that overexpress folate receptors such as OVCAR-3 and DLD-1. In addition, the study of the potential modulation of the soluble folate receptor alpha (FOLR1) by treatment with the synthesized materials has been carried out using OVCAR-3, DLD-1, A2780 and A431 tumour cell lines. The results show that a relatively high concentration of folic acid functionalization of the nanostructured silica together with the incorporation of the cytotoxic tin fragment leads to an increase in the quantity of the soluble FOLR1 secreted by the tumour cells. In addition, the studies reported here show that this increase of the soluble FOLR1 occurs presumably by cutting the glycosyl-phosphatidylinositol anchor of membrane FR-α and by the release of intracellular FR-α. This study validates the potential use of a combination of mesoporous silica materials co-functionalized with folate targeting molecules and an organotin(IV) drug as a strategy for the therapeutic treatment of several cancer cells overexpressing folate receptors.

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Section: Resultsmentioning

confidence: 50%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Role of Folic Acid in the Therapeutic Action of Nanostructured Porous Silica Functionalized with Organotin(IV) Compounds against Different Cancer Cell Lines

et al. 2020

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“…When NaOH is used to catalyze the synthesis of MSN, typically a high reaction temperature (80–100 °C) and a large volume of aqueous base (200–1000 mL) are required [ 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 ] to contain MSN size in sub-micrometer regime [ 49 ]. In fact, such a temperature range, required to trigger nucleation and MSN formation, results in the formation of large, micrometer-sized, silica particles aggregates, and the use of large volume of aqueous NaOH limits particle aggregation and uncontrolled formation of larger MSNs thanks to dilution.…”

Section: Introductionmentioning

confidence: 99%

High Surface Area Mesoporous Silica Nanoparticles with Tunable Size in the Sub-Micrometer Regime: Insights on the Size and Porosity Control Mechanisms

et al. 2021

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Mesoporous silica nanostructures (MSNs) attract high interest due to their unique and tunable physical chemical features, including high specific surface area and large pore volume, that hold a great potential in a variety of fields, i.e., adsorption, catalysis, and biomedicine. An essential feature for biomedical application of MSNs is limiting MSN size in the sub-micrometer regime to control uptake and cell viability. However, careful size tuning in such a regime remains still challenging. We aim to tackling this issue by developing two synthetic procedures for MSN size modulation, performed in homogenous aqueous/ethanol solution or two-phase aqueous/ethyl acetate system. Both approaches make use of tetraethyl orthosilicate as precursor, in the presence of cetyltrimethylammonium bromide, as structure-directing agent, and NaOH, as base-catalyst. NaOH catalyzed syntheses usually require high temperature (>80 °C) and large reaction medium volume to trigger MSN formation and limit aggregation. Here, a successful modulation of MSNs size from 40 up to 150 nm is demonstrated to be achieved by purposely balancing synthesis conditions, being able, in addition, to keep reaction temperature not higher than 50 °C (30 °C and 50 °C, respectively) and reaction mixture volume low. Through a comprehensive and in-depth systematic morphological and structural investigation, the mechanism and kinetics that sustain the control of MSNs size in such low dimensional regime are defined, highlighting that modulation of size and pores of the structures are mainly mediated by base concentration, reaction time and temperature and ageing, for the homogenous phase approach, and by temperature for the two-phase synthesis. Finally, an in vitro study is performed on bEnd.3 cells to investigate on the cytotoxicity of the MNSs.

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“…This group grafted diethylenetriamine group and tin compound on the MSNs in a successive step. Their result indicated that the functionalization occurred inside the pores of MSNs [ 73 ].…”

Section: Fabrication Of Msnsmentioning

confidence: 99%

Progress in Mesoporous Silica Nanoparticles as Drug Delivery Agents for Cancer Treatment

et al. 2021

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Cancer treatment and therapy have made significant leaps and bounds in these past decades. However, there are still cases where surgical removal is impossible, metastases are challenging, and chemotherapy and radiotherapy pose severe side effects. Therefore, a need to find more effective and specific treatments still exists. One way is through the utilization of drug delivery agents (DDA) based on nanomaterials. In 2001, mesoporous silica nanoparticles (MSNs) were first used as DDA and have gained considerable attention in this field. The popularity of MSNs is due to their unique properties such as tunable particle and pore size, high surface area and pore volume, easy functionalization and surface modification, high stability and their capability to efficiently entrap cargo molecules. This review describes the latest advancement of MSNs as DDA for cancer treatment. We focus on the fabrication of MSNs, the challenges in DDA development and how MSNs address the problems through the development of smart DDA using MSNs. Besides that, MSNs have also been applied as a multifunctional DDA where they can serve in both the diagnostic and treatment of cancer. Overall, we argue MSNs provide a bright future for both the diagnosis and treatment of cancer.

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Mesoporous silica nanoparticles functionalized with a dialkoxide diorganotin(IV) compound: In search of more selective systems against cancer cells

Cited by 28 publications

References 46 publications

Role of Folic Acid in the Therapeutic Action of Nanostructured Porous Silica Functionalized with Organotin(IV) Compounds against Different Cancer Cell Lines

Role of Folic Acid in the Therapeutic Action of Nanostructured Porous Silica Functionalized with Organotin(IV) Compounds against Different Cancer Cell Lines

High Surface Area Mesoporous Silica Nanoparticles with Tunable Size in the Sub-Micrometer Regime: Insights on the Size and Porosity Control Mechanisms

Progress in Mesoporous Silica Nanoparticles as Drug Delivery Agents for Cancer Treatment

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