Mesothelial Splenic Cyst.

Kuwabara, Saburoh; Hohjoh, Hitoshi; Nakano, Masaru; Ebihara, Yoshirou; Toyama, Keisuke

doi:10.2169/internalmedicine.32.672

Cited by 16 publications

(20 citation statements)

References 5 publications

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“…Most benign, nonparasitic cysts of the spleen are endothelial or epidermoid, while mesothelial cysts are very uncommon. 11 In a study of 651 cases of nonparasitic splenic cysts, only 4 cases (4.9%) were mesothelial. 12 The differential diagnosis of primary malignant mesothelioma of the spleen includes some biologically distinct entities, namely, localized mesothelioma, secondary involvement of the spleen by a peritoneal or pleural mesothelioma, primary splenic tumors and metastases.…”

Section: Discussionmentioning

confidence: 98%

Localized Intrasplenic Mesothelioma

et al. 2013

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Malignant mesothelioma is a primary neoplasm of the serosal membranes that usually presents with a diffuse pattern of growth. However, cases of localized mesotheliomas have been described. The predominant localization is the pleura; peritoneum and pericardium being rarer localizations. Only few cases of true intraparenchymal mesothelioma arising in organs such as liver, gonads, lung, and pancreas have been described. We report a case of an otherwise healthy 48-year-old man without asbestos exposure with a nodule of 3 cm in diameter, localized in the spleen, discovered incidentally at the ultrasonographic examination, for which histopathological and immunohistochemical findings were consistent with epithelioid mesothelioma: large round cells with eosinophil dense cytoplasm and macronucleoli and with immunohistochemical positivity for pancytokeratins, calretinin, Wilms tumor-1, and others markers of mesothelial differentiation. The diagnosis of localized intrasplenic epithelioid malignant mesothelioma was carried out. To the best of our knowledge, this is the first case of a localized intrasplenic mesothelioma published in the indexed literature.

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Section: Discussionmentioning

confidence: 98%

Localized Intrasplenic Mesothelioma

et al. 2013

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“…Clinically, primary cysts occur predominantly in children and young adolescents; often asymptomatic until they assume large sizes, they may then present with local or referred pain, abdominal distension compression of adjacent structures and rarely as thrombocytopenia 1 6 7…”

Section: Discussionmentioning

confidence: 99%

“…Capsular surface mesothelial invagination with subsequent cyst formation,6 embryonic inclusion of epithelial cells from adjacent structures, epithelial cell metaplasia from adjacent structures or vascular endothelium from peritoneal inclusions are some of the theories put forth to explain the genesis of these congenital cysts 1…”

Section: Discussionmentioning

confidence: 99%

“…The cyst wall is generally lined by a single cell series of mesothelial, transitional or squamous epithelium 1 8. Occasional finding of combination of epithelial cells may be explained by the pluripotent nature of the mesothelial cells 2.…”

Section: Discussionmentioning

confidence: 99%

“…Derived from the mesothelial cell lining of the splenic capsule,1 these uncommon true cysts may remain asymptomatic for a long time2 and have a characteristic gross and microscopic appearance 1 2. The lining cells stain positive for calretinin, a mesothelial marker, and secrete CA 19-9 which can be used as a screening tool in the management of these lesions 3 4.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Mesothelial cyst of the spleen in an adult: a case report

Vijayaraghavan¹,

Chandrashekar²,

Aithal³

et al. 2010

Case Reports

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SummaryA young adult in her third decade presented with a 2-week history of catching left upper abdominal pain and was detected to have a cystic lesion occupying almost the entire spleen. Laparoscopic total splenectomy was carried out, and the cyst wall revealed a true mesothelial cyst with no squamous metaplasia. The various aspects of mesothelial cysts, including immunophenotyping and treatment modalities, are briefly discussed. BACKGROUND

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Multicystic Mesothelial Cyst of the Mediastinum: Report of a Case

Sasaki¹,

Yano²,

Kiriyama³

et al. 2003

Surgery Today

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We report the rare case of a multicystic mesothelial cyst of the mediastinum. A 43-year-old man was referred to our department after a routine chest X-ray showed an anterior mediastinum mass. The lesion was resected by thoracoscopy, which revealed multicystic, thin-walled tense masses arising in the anterior mediastinum. The cysts were not adherent to the pericardium or to the thymus of the right lobe. Immunohistochemistry revealed that the cyst was lined with a layer of mesothelial cells and there were no malignant foci. The lining cells were positive for keratin and negative for the lymphocyte marker. These findings were consistent with a diagnosis of multicystic mesothelial cyst.

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Mesothelial Splenic Cyst.

Cited by 16 publications

References 5 publications

Localized Intrasplenic Mesothelioma

Localized Intrasplenic Mesothelioma

Mesothelial cyst of the spleen in an adult: a case report

Multicystic Mesothelial Cyst of the Mediastinum: Report of a Case

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