Mesothelial Stem Cells and Stromal Vascular Fraction

Chernoff, Greg; Bryan, Nathan S.; Park, Andrea M

doi:10.1016/j.fsc.2018.06.009

Cited by 11 publications

(6 citation statements)

References 46 publications

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“…It has been suggested that ADSC, when surrounded with other cells proper of their natural niche and matrix, can potentiate their regenerative actions in wound healing. 33 As a consequence, it may be expected that adipose tissue derivatives such as fat grafts express a better wound healing than ADSC. However, when ADSC efficacy was compared with fat graft, no difference was found among these treatment groups.…”

Section: Adsc Versus Other Adipose Tissue Derivativesmentioning

confidence: 99%

Adipose-Derived Stem Cells Therapy for Radiation-Induced Skin Injury

Huayllani¹,

Ruiz‐Garcia

Boczar³

et al. 2021

Ann Plast Surg

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Background Radiation-induced skin injuries have been treated with different medical therapies and have shown diverse outcomes. We aim to evaluate the effect of adipose-derived stem cells (ADSCs) therapy on radiation-induced skin injury. Methods We performed a review by querying PubMed, Ovid MEDLINE, and EMBASE databases from inception to April 2020 following Preferred Reporting Items for Systematic reviews and Meta-Analyses guidelines. The MeSH terms “adipose-derived stem cells,” “wound healing,” “radiation,” and synonyms in combinations determined our search strategy. Experimental peer-reviewed articles describing the protocol and comparing the results with controls were included. Non-English studies were excluded. Results Our search recorded a total of 137 articles. Only 8 studies met our inclusion criteria and were included in this review. Five studies evaluated the use of ADSC alone, whereas the others evaluated the efficacy of ADSC seeded in scaffolds. Adipose-derived stem cell–based therapies, either alone or seeded in scaffolds, were shown to improve wound healing in most studies when compared with controls. Conclusions There is evidence supporting the positive benefits from ADSC-based therapies in radiation-induced skin injury. However, further studies are needed to standardize the method of ADSC extraction, radiation-induced skin injury experimental model, and increase the time of follow-up to evaluate the results accurately.

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Section: Adsc Versus Other Adipose Tissue Derivativesmentioning

confidence: 99%

Adipose-Derived Stem Cells Therapy for Radiation-Induced Skin Injury

Huayllani¹,

Ruiz‐Garcia

Boczar³

et al. 2021

Ann Plast Surg

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“…2 In recent years, more research has emerged focusing on aesthetic and reconstructive surgical applications. 3,4 Many authors are focusing on the utilization of exosomes for treating aging skin, acne, alopecia, wound healing, and scar therapy, particularly hypertrophic and keloid scars. 5,6 The mechanism of action of mesenchymal stem cells (MSCs) in regeneration remains under study.…”

Section: Introductionmentioning

confidence: 99%

“…The importance of nitric oxide in cellular medicine, regenerative, and stem cell therapy has also been highlighted in the literature. 4 The role of NO in stem cell biology has revealed novel strategies for optimizing metabolism for regenerative and healing outcomes.…”

Section: Introductionmentioning

confidence: 99%

“…Studies showed that the NO lozenge could modify cardiac risk factors in patients over 40, reduce triglycerides, and reduce blood pressure. The importance of nitric oxide in cellular medicine, regenerative, and stem cell therapy has also been highlighted in the literature 4 . The role of NO in stem cell biology has revealed novel strategies for optimizing metabolism for regenerative and healing outcomes.…”

Section: Introductionmentioning

confidence: 99%

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Combining topical dermal infused exosomes with injected calcium hydroxylapatite for enhanced tissue biostimulation

Chernoff¹

2023

J of Cosmetic Dermatology

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Background: Exosome research continues to flourish. Subsequent knowledge surrounding indications, dose-response, safety, efficacy, and the ability to combine exosome treatment as a "skin primer"-for biostimulation modalities such as calcium hydroxylapatite (CaHA), platelet-rich plasma (PRP), and platelet-rich fibrin matrix (PRFM) is growing rapidly. The objective of this study was to develop safe, reproducible methods of improving topical exosome absorption to enhance the quality of skin either by themselves, or in combination with injectable CaHA.

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“…Very little has been written on the neuroprotective or neuroregenerative effects of SVF [33]. However, protective and regenerative effects on other organ tissues has [34][35][36][37]. This raises a very important practical question about the safest, most efficient, and simplest type of stem cell source.…”

Section: Introductionmentioning

confidence: 99%

Human intracerebroventricular (ICV) injection of autologous, non-engineered, adipose-derived stromal vascular fraction (ADSVF) for neurodegenerative disorders: results of a 3-year phase 1 study of 113 injections in 31 patients

Duma¹,

Kopyov²,

Kopyov³

et al. 2019

Mol Biol Rep

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We have chosen to test the safety of human intracerebroventricular (ICV) brain injections of autologous non-geneticallymodified adipose-derived stromal vascular fraction (ADSVF). In this IRB-approved trial, 24 patients received ICV ADSVF via an implanted reservoir between 5/22/14 and 5/22/17. Seven others were injected via their ventriculo-peritoneal shunts. Ten patients had Alzheimer's disease (AD), 6 had amyotrophic lateral sclerosis (ALS), 6 had progressive multiple sclerosis (MS-P), 6 had Parkinson's "Plus" (PD+), 1 had spinal cord injury, 1 had traumatic brain injury, and 1 had stroke. Median age was 74 (range 41-83). Injections were planned every 2-3 months. Thirty-one patients had 113 injections. Patients received SVF injection volumes of 3.5-20 cc (median:4 cc) containing 4.05 × 10 5 to 6.2 × 10 7 cells/cc, which contained an average of 8% hematopoietic and 7.5% adipose stem cells. Follow-up ranged from 0 to 36 months (median: 9.2 months). MRIs post injection(s) were unchanged, except for one AD patient whose hippocampal volume increased from < 5th percentile to 48th percentile (NeuroQuant ® volumetric MRI). Of the 10 AD patients, 8 were stable or improved in tests of cognition. Two showed improvement in P-tau and ß-amyloid levels. Of the 6 MS-P patients all are stable or improved. Four of 6 ALS patients died of disease progression. Twelve of 111 injections (11%) led to 1-4 days of transient meningismus, and mild temperature elevation, which resolved with acetaminophen and/or dexamethasone. Two (1.8% of injections) required hospitalization for these symptoms. One patient (0.9% of injections) had his reservoir removed and later replaced for presumed infection. In this Phase 1 safety trial, ADSVF was safely injected into the human brain ventricular system in patients with no other treatment options. Secondary endpoints of clinical improvement or stability were particularly promising in the AD and MS-P groups. These results will be submitted for a Phase 2 FDA-approved trial.

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Mesothelial Stem Cells and Stromal Vascular Fraction

Cited by 11 publications

References 46 publications

Adipose-Derived Stem Cells Therapy for Radiation-Induced Skin Injury

Adipose-Derived Stem Cells Therapy for Radiation-Induced Skin Injury

Combining topical dermal infused exosomes with injected calcium hydroxylapatite for enhanced tissue biostimulation

Human intracerebroventricular (ICV) injection of autologous, non-engineered, adipose-derived stromal vascular fraction (ADSVF) for neurodegenerative disorders: results of a 3-year phase 1 study of 113 injections in 31 patients

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