Meta-analyses of cognitive functioning in euthymic bipolar patients and their first-degree relatives

Arts, Baer; Jabben, Nienke; Krabbendam, Lydia; Os, Jim van

doi:10.1017/s0033291707001675

Cited by 626 publications

(638 citation statements)

References 87 publications

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“…The similarities in functional hemispheric asymmetries between the euthymic BD patients of the present study and healthy men high in impulsive nonconformity, suggests that BD-related personality traits can already be linked to atypical right hemisphere functioning in emotional prosody, even when not exceeding the pathological level. The idea of a vulnerability marker in BD has been further supported by a meta-analysis comparing euthymic BD and their first-degree healthy relatives, who showed similar cognitive impairments, albeit to a lesser degree (Arts et al, 2008). …”

Section: Discussionmentioning

confidence: 98%

Atypical right hemispheric functioning in the euthymic state of bipolar affective disorder

Najt

Hausmann

2014

Psychiatry Research

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Section: Discussionmentioning

confidence: 98%

Atypical right hemispheric functioning in the euthymic state of bipolar affective disorder

Najt

Hausmann

2014

Psychiatry Research

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“…It activates language-related regions involved in the pathophysiology of both disorders (Lawrie and Abukmeil, 1998;Shenton et al, 2001;Glahn et al, 2008;Minzenberg et al, 2009). Moreover, it probes neuropsychological deficits in executive function, verbal initiation, and verbal fluency commonly observed in patients (Gourovitch and Goldberg, 1996;Heinrichs and Zakzanis, 1998;Bokat and Goldberg, 2003;Arts et al, 2008).…”

Section: Introductionmentioning

confidence: 96%

Impact of a microRNA MIR137 Susceptibility Variant on Brain Function in People at High Genetic Risk of Schizophrenia or Bipolar Disorder

Whalley

Papmeyer

Romaniuk

et al. 2012

Neuropsychopharmacol

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A recent 'mega-analysis' combining genome-wide association study data from over 40 000 individuals identified novel genetic loci associated with schizophrenia (SCZ) at genome-wide significance level. The strongest finding was a locus within an intron of a putative primary transcript for microRNA MIR137. In the current study, we examine the impact of variation at this locus (rs1625579, G/T; where T is the common and presumed risk allele) on brain activation during a sentence completion task that differentiates individuals with SCZ, bipolar disorder (BD), and their relatives from controls. We examined three groups of individuals performing a sentence completion paradigm: (i) individuals at high genetic risk of SCZ (n ¼ 44), (ii) individuals at high genetic risk of BD (n ¼ 90), and (iii) healthy controls (n ¼ 81) in order to test the hypothesis that genotype at rs1625579 would influence brain activation. Genotype groups were assigned as 'RISKÀ' for GT and GG individuals, and 'RISK + ' for TT homozygotes. The main effect of genotype was significantly greater activation in the RISKÀ individuals in the posterior right medial frontal gyrus, BA 6. There was also a significant genotype*group interaction in the left amygdala and left pre/postcentral gyrus. This was due to differences between the controls (where individuals with the RISKÀ genotype showed greater activation than RISK + subjects) and the SCZ high-risk group, where the opposite genotype effect was seen. These results suggest that the newly identified SCZ locus may influence brain activation in a manner that is partly dependent on the presence of existing genetic susceptibility for SCZ.

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“…In three analyses of the endophenotype of bipolar disorder with patients, unaffected first-degree relatives (fathers, mothers, brothers, twins, and children), and control targets, the endophenotype markers were shown through neuropsychological measures (10,33) . However, a meta-analysis claims that these findings should be interpreted with caution, as it is very likely that the confusion of factors such as medication, chronicity, and affective symptoms below the threshold are also contributing to the observed results (34) .…”

Section: Neuropsychology Of Bipolar Disordermentioning

confidence: 99%

“…Surveys report that individuals in the manic phase have greater difficulty in processing visuospatial information and verbal fluency (33) . There is a clear potential for losses due to the level of disorganization of behavior and acceleration of mental activity, especially in the presence of psychotic symptoms (37) .…”

Section: Neuropsychology Of Bipolar Disordermentioning

confidence: 99%

Model endophenotype for bipolar disorder: Qualitative Analysis, etiological factors, and research areas

Tavares

Neves

Malloy-Diniz

2014

Rev. esc. enferm. USP

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Modelo de endofenótipo do transtorno Bipolar: análise qualitativa, fatores etiológicos e âMBitos de investigação aBordados Modelo endofenotipo de trastorno Bipolar: análisis cualitativo, factores etiológicos y las áreas para las cuales la investigación 1 professor of psychology, school of education, federal university of goiás and doctoral student of the post graduate program in neurosciences at the federal university of Minas gerais, Belo Horizonte, Brazil. AbSTrAcTThe aim of this study is to present an updated view of the writings on the endophenotype model for bipolar disorder using analytical methodologies. A review and analysis of networks was performed through descriptors and keywords that characterize the composition of the endophenotype model as a model of health. Information was collected from between 1992 and 2014, and the main thematic areas covered in the articles were identified. We discuss the results and question their cohesion, emphasizing the need to strengthen and identify the points of connection between etiological factors and characteristics that make up the model of endophenotypes for bipolar disorder. DeScripTOrSEndophenotypes Bipolar disorders Health models Analysis qualitative reSuMeN El objetivo de este trabajo es presentar una visión actualizada de los escritos del modelo endofenotipo para el trastorno bipolar, el uso de las metodologías analíticas. Se realizó una revisión de este tipo de literatura y un análisis de las redes a través de descriptores y palabras clave que caracterizan la composición del modelo endofenotipo como modelo de salud. El momento de la recolección de la información se produjo entre los años 1992-2014, la identificación de las principales áreas temáticas incluidas en los artículos. Se discuten los resultados para la consolidación del modelo de endofenotipos, cuestionando la cohesión y haciendo hincapié en la necesidad de fortalecer e identificar los puntos de conexión entre los factores etiológicos y característi-cas que conforman el modelo de endofenotipos para el trastorno bipolar. DeScripTOreS

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Meta-analyses of cognitive functioning in euthymic bipolar patients and their first-degree relatives

Abstract: Executive function and verbal memory are candidate bipolar endophenotypes given large deficits in these domains in bipolar patients and small, but intermediate, cognitive impairments in first-degree relatives.

Cited by 626 publications

References 87 publications

Atypical right hemispheric functioning in the euthymic state of bipolar affective disorder

Atypical right hemispheric functioning in the euthymic state of bipolar affective disorder

Impact of a microRNA MIR137 Susceptibility Variant on Brain Function in People at High Genetic Risk of Schizophrenia or Bipolar Disorder

Model endophenotype for bipolar disorder: Qualitative Analysis, etiological factors, and research areas

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