Meta-analysis demonstrates no association between XRCC1 Arg399Gln polymorphism and bladder cancer risk

Dong, Lihua; Zhang, Xin Yan; Teng, H.; Li, M.S.; Wang, P.

doi:10.4238/2014.november.28.2

Cited by 7 publications

(3 citation statements)

References 35 publications

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“…In X-ray repair cross-complementing protein 1 (XRCC1), rs1799782 and rs25489 are widely associated with an increased risk for BC, especially in Asian and Indian populations [146][147][148][149][150][151][152]. Rs915927 in the same gene increases tumor susceptibility in the Italian population [153] while rs25487 gave contradictory results in different studies [147][148][149][154][155][156][157][158][159]. Rs3218373, rs3218536, and rs6464268 in XRCC2 present a protective effect towards BC in the Italian population [160].…”

Section: Dna Repairmentioning

confidence: 99%

Genetic Polymorphisms Involved in Bladder Cancer: A Global Review

Kourie,

Zouein,

Succar

et al. 2023

Oncol Rev.

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Bladder cancer (BC) has been associated with genetic susceptibility. Single peptide polymorphisms (SNPs) can modulate BC susceptibility. A literature search was performed covering the period between January 2000 and October 2020. Overall, 334 articles were selected, reporting 455 SNPs located in 244 genes. The selected 455 SNPs were further investigated. All SNPs that were associated with smoking and environmental exposure were excluded from this study. A total of 197 genes and 343 SNPs were found to be associated with BC, among which 177 genes and 291 SNPs had congruent results across all available studies. These genes and SNPs were classified into eight different categories according to their function.

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Section: Dna Repairmentioning

confidence: 99%

Genetic Polymorphisms Involved in Bladder Cancer: A Global Review

Kourie,

Zouein,

Succar

et al. 2023

Oncol Rev.

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“…1 – 4 XRCC genes are involved in base excision repair (BER) and single-strand break in damaged DNA in human genome. 1 – 5 Molecular epidemiological studies have shown that XRCC genes are significantly associated with lung cancer, 6 – 9 oral cancer, 10 bladder cancer, 11 – 13 ovarian cancer, 14 , 15 esophageal cancer, 16 and gastric cancer. 17 – 23 Moreover, studies have revealed that XRCC gene polymorphism is highly variable in different ethnic populations.…”

Section: Introductionmentioning

confidence: 99%

DNA Repair Mechanism Gene, XRCC1A (Arg194Trp) but not XRCC3 (Thr241Met) Polymorphism Increased the Risk of Breast Cancer in Premenopausal Females: A Case–Control Study in Northeastern Region of India

Devi

Ahmed

Narain

et al. 2017

Technol Cancer Res Treat

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X-ray repair cross complementary group gene is one of the most studied candidate gene involved in different types of cancers. Studies have shown that X-ray repair cross complementary genes are significantly associated with increased risk of breast cancer in females. Moreover, studies have revealed that X-ray repair cross complementary gene polymorphism significantly varies between and within different ethnic groups globally. The present case–control study was aimed to investigate the association of X-ray repair cross complementary 1A (Arg194Trp) and X-ray repair cross complementary 3 (Thr241Met) polymorphism with the risk of breast cancer in females from northeastern region of India. The present case–control study includes histopathologically confirmed and newly diagnosed 464 cases with breast cancer and 534 apparently healthy neighborhood community controls. Information on sociodemographic factors and putative risk factors were collected from each study participant by conducting face-to-face interviews. Genotyping of X-ray repair cross complementary 1A (Arg194Trp) and X-ray repair cross complementary 3 (Thr241Met) was carried out by polymerase chain reaction-restriction fragment length polymorphism. For statistical analysis, both univariate and multivariate logistic regression analyses were performed. We also performed stratified analysis to find out the association of X-ray repair cross complementary genes with the risk of breast cancer stratified based on menstrual status. This study revealed that tryptophan allele (R/W-W/W genotype) in X-ray repair cross complementary 1A (Arg194Trp) gene significantly increased the risk of breast cancer (adjusted odds ratio = 1.44, 95% confidence interval = 1.06-1.97, P < .05 for R/W-W/W genotype). Moreover, it was found that tryptophan allele (W/W genotype) at codon 194 of X-ray repair cross complementary 1A (Arg194Trp) gene significantly increased the risk of breast cancer in premenopausal females (crude odds ratio = 1.66, 95% confidence interval = 1.11-2.46, P < .05 for R/W-W/W genotype). The present study did not reveal any significant association of X-ray repair cross complementary 3 (Thr241Met) polymorphism with the risk of breast cancer. The present study has explored that X-ray repair cross complementary 1A (Arg194Trp) gene polymorphism is significantly associated with the increased risk of breast cancer in premenopausal females from northeastern region of India which may be beneficial for prognostic purposes.

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“…В ряді робіт показана асоціація носійства поліморфних алелей гену XRCC1 з ризиком розвитку ряду злоякісних новоутворень (рак молочної залози, рак шлунка, колоректальний рак, рак легень) [21][22][23][24]. Поряд з тим, існують роботи, в яких не виявлено подібних асоціацій [25,26]. Показано, що за умов дії іонізуючої радіації у гомозиготних носіїв поліморфного алелю XRCC1 Gln399Gln швидкість репарації пошкоджень ДНК менша, ніж у гомозигот за домінантною алеллю [27].…”

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Polymorphism of DNA Repair Genes XRCC1 and XPD in Patients with Thyroid Cancer Exposed to Ionizing Radiation as a Result of the Chernobyl Disaster

Henyk–Berezovska¹,

Klymenko²

2019

Ukr. ž. med. bìol. sportu

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Meta-analysis demonstrates no association between XRCC1 Arg399Gln polymorphism and bladder cancer risk

Cited by 7 publications

References 35 publications

Genetic Polymorphisms Involved in Bladder Cancer: A Global Review

Genetic Polymorphisms Involved in Bladder Cancer: A Global Review

DNA Repair Mechanism Gene, XRCC1A (Arg194Trp) but not XRCC3 (Thr241Met) Polymorphism Increased the Risk of Breast Cancer in Premenopausal Females: A Case–Control Study in Northeastern Region of India

Polymorphism of DNA Repair Genes XRCC1 and XPD in Patients with Thyroid Cancer Exposed to Ionizing Radiation as a Result of the Chernobyl Disaster

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