Meta-Analysis for Epigenome-Wide Association Studies

Wang, Nan; Jin, Shuilin

doi:10.1007/978-1-0716-1994-0_8

Cited by 1 publication

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“…[ 44 ] These studies have underscored the influence of cellular phenotypes on the etiology and outcomes of complex diseases, with genomic DNA modification through epigenetic mechanisms playing a pivotal role in these effects. [ 45 , 46 ] EWAS can mitigate the risk of false positives often encountered in studies and reveal significant regulatory relationships between the epigenome and RA through the analysis of large-scale methylation quantitative trait loci. [ 47 ] Furthermore, EWAS can identify common apparent mutations in disease by detecting the distribution of methyl groups.…”

Section: Discussionmentioning

confidence: 99%

Global research trends in DNA methylation in rheumatoid arthritis: A bibliometric analysis and visual analysis

Huang,

Gao

et al. 2024

Medicine

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Rheumatoid arthritis (RA) is a prevalent autoimmune disorder with a significant global economic burden. Epigenetic modifications, particularly DNA methylation, play a crucial role in RA. This study conducted a bibliometric analysis to explore the evolving trends and predominant themes in RA and DNA methylation research over the past two decades. A total of 1800 articles met the inclusion criteria, and the analysis revealed consistent growth in the literature, with a notable increase in output after 2019. The research involved 70 countries, 2139 academic institutions, 23,365 unique authors, and 58,636 co-cited authors. The United States emerged as a dominant contributor in this research domain. The significance of DNA methylation in shaping research directions for RA management is increasingly evident. Recent investigations have shed light on the pivotal role of DNA methylation in RA, particularly in characterizing synovial tissue and exploring the underlying mechanisms of disease pathogenesis. This study provides valuable insights into the landscape of DNA methylation research in RA and highlights the importance of epigenetics in autoimmune diseases.

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