2013
DOI: 10.3923/pjbs.2013.1226.1237
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Meta-analysis of Genetic Polymorphisms and Ophthalmologic Disease Risk in Asian Populations: a Case of DNA Repair XRCC1 Gene

Abstract: This study aimed to assess a meta-analysis of the association of XRCC1 polymorphisms with the risk of various ophthalmologic diseases in Asian population. This meta-analysis was performed by critically reviewing reveals 38 studies involving 1373 cases and 1745 controls. Among all the eligible studies, one focused on Arg194Trp polymorphism, nine described the Arg399Gln and no article investigated on Arg280His. There was a large between-study heterogeneity in ORs of individual studies of the dominant model (chi2… Show more

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