Meta‐analysis of microarray data to determine gene indicators involved in cisplatin resistance in non‐small cell lung cancer
Somayeh Hashemi Sheikhshabani,
Paratoo Modarres,
Soudeh Ghafouri‐Fard
et al.
Abstract:BackgroundLung cancer is a major cause of cancer‐related mortality worldwide, with a 5‐year survival rate of approximately 22%. Cisplatin is one of the standard first‐line chemotherapeutic agents for non‐small cell lung cancer (NSCLC), but its efficacy is often limited by the development of resistance. Despite extensive research on the molecular mechanisms of chemoresistance, the underlying causes remain elusive and complex.AimsWe analyzed three microarray datasets to find the gene signature and key pathways r… Show more
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