Meta-analysis of psoriasis, cardiovascular disease, and associated risk factors

Miller, Iben Marie; Ellervik, Christina; Yazdanyar, Shiva; Jemec, Gregor B. E.

doi:10.1016/j.jaad.2013.06.053

Cited by 275 publications

(289 citation statements)

References 15 publications

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“…In some instances, we found that the language reported in these reviews was vague. For example, Miller et al noted that ''additional relevant articles were found by manual inspection'' [5]. Such statements are not sufficient to determine the true nature of these manual searches.…”

Section: Discussionmentioning

confidence: 99%

Manual search approaches used by systematic reviewers in dermatology

Vassar

Atakpo

Kash

2017

jmla

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Objective: Manual searches are supplemental approaches to database searches to identify additional primary studies for systematic reviews. The authors argue that these manual approaches, in particular hand-searching and perusing reference lists, are often considered the same yet lead to different outcomes.Methods: We conducted a PubMed search for systematic reviews in the top 10 dermatology journals (January 2006-January 2016. After screening, the final sample comprised 292 reviews. Statements related to manual searches were extracted from each review and categorized by the primary and secondary authors. Each statement was categorized as either ''Search of Reference List,'' ''Hand Search,'' ''Both,'' or ''Unclear.''Results: Of the 292 systematic reviews included in our sample, 143 reviews (48.97%) did not report a hand-search or scan of reference lists. One-hundred thirty-six reviews (46.58%) reported searches of reference lists, while 4 reviews (1.37%) reported systematic hand-searches. Three reviews (1.03%) reported use of both hand-searches and scanning reference lists. Six reviews (2.05%) were classified as unclear due to vague wording.Conclusions: Authors of systematic reviews published in dermatology journals in our study sample scanned reference lists more frequently than they conducted hand-searches, possibly contributing to biased search outcomes. We encourage systematic reviewers to routinely practice hand-searching in order to minimize bias. Well-conducted systematic reviews are the apex of the evidence hierarchy and routinely used for developing care guidelines and informing clinical decision making [1]. While each aspect of systematic review methodology is important, the search process, when thorough and well produced, leads to a set of research evidence to consider for inclusion that minimizes bias. There is a substantial body of evidence pointing to the importance of thorough and prespecified search strategies involving multiple databases to locate relevant studies and minimize the potential for publication and language bias [2]. As part of the search process, systematic reviewers often review reference lists of other studies or conduct hand-searches to identify additional primary studies. It is the authors' experience that reviewing reference lists and conducting hand-searches are often considered the same, yet we argue that these processes are quite different and lead to different outcomes.Our objective was to assess how often systematic reviewers in dermatology actually conducted handsearches when performing a systematic review.

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Section: Discussionmentioning

confidence: 99%

Manual search approaches used by systematic reviewers in dermatology

Vassar

Atakpo

Kash

2017

jmla

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“…The following odds ratios were found: ischaemic heart disease (1.5) and peripheral vascular disease (1.5). No significant effect on cerebrovascular disease and cardiovascular mortality was observed [66]. Another study combined plaque psoriasis and psoriatic arthritis.…”

Section: Sheets For the Presentationmentioning

confidence: 99%

Biologicals in the Treatment of Plaque Psoriasis: Drug Selection by Means of the SOJA Method

Janknegt¹

2016

J Pharma Care Health Sys

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The treatment of plaque psoriasis is changing because of the introduction of new treatment options. The goal of this article is to allow a transparent and rational choice of medicines by means of the System of Objectified Judgement Analysis. The following selection criteria (relative weight) were applied: approved indications (40), drug interactions (60), clinical efficacy (400), safety (300), dosage frequency (100) and documentation (100). Acquisition cost was not taken into consideration to allow a preselection on quality aspects only. Adalimumab, etanercept, infliximab and ustekinumab were compared on these criteria. Infliximab and ustekinumab showed the highest scores and are the most suitable medicines for the treatment of severe plaque psoriasis. Of course, cost will play a key role in the final selection in individual hospitals. Weight Approved indications 40 Drug Interactions 60Clinical efficacy 400Safety 300Dosage frequency 100 Documentation 100Total 1000 Selection Criteria Approved IndicationsThe number of licensed indications is a good measure of the applicability and documentation of the drugs. Although this analysis is limited to the treatment of plaque psoriasis, the fact that a drug is approved for (almost) all indications listed below is, from a formulary point of view, advantageous to another drug, which is approved for only one or two applications.The percentage of the maximum score for approved indications was obtained as follows (Table 2): IndicationMaximum Score (%)Plaque psoriasis 50% Psoriatric arthritis 20%Rheumatoid arthritis 10% Spondylitis ankylopoetica 10%Inflammatory bowel disease 10% Drug interactionsInteractions play a role only in patients who use other drugs which may interact with biologicals. However, it is a relevant criterion from a formulary point of view.The score for each drug was dependent on the frequency and severity of observed drug interactions. Clinical efficacyClinical efficacy is always a very important selection criterion for any group of drugs. The score for each drug was derived from the results of double-blind comparative studies. SafetyThe extent and the severity of adverse effects is another important selection criterion for drugs. A distinction was made between "minor" side effects, such as gastrointestinal disturbances or skin reactions, occurring in clinical trials and severe or even life-threatening adverse reactions observed with large scale use of the drugs. The evaluation of the "minor" adverse effects was based on results of double blind comparative clinical studies.

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“…Patients with psoriasis have a high risk of developing cardiovascular disease, diabetes, metabolic syndrome, and depression. [1][2][3][4] Although the etiology and pathogenesis of psoriasis remain unclear, it has been suggested that hereditary and environmental factors play pivotal roles in psoriasis. Psoriasis has a significant impact on quality of life, even in patients whose affected body surface area is relatively small.…”

Section: Introductionmentioning

confidence: 99%

“…42 Miller et al found that ethnicity did not influence the link between obesity and psoriasis. 4 Obesity was reported to reduce the reaction to systemic therapy and the retention rate of tumor necrosis factor (TNF)-alpha blockers. 43,44 Weight reduction can improve sensitivity to low-dose cyclosporine.…”

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confidence: 99%

Epidemiology and treatment of psoriasis: a Chinese perspective

Pan¹,

Zhang²

2014

PTT

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Background: Psoriasis is a chronic inflammatory skin disease that has a negative impact on quality of life. Prevalence and management of psoriasis varies among different ethnic groups. Objectives: To evaluate the epidemiology and treatment of psoriasis from a Chinese perspective. Methods: A systematic search was performed on PubMed and the China National Knowledge Infrastructure using the following MeSH terms: "psoriasis" and ("prevalence" or "epidemiology") and "risk factor" and ("management" or "treatment"). The search included all citations from 1975 to 2013. Data were sorted by prevalence, age of onset, sex distribution, type, severity, risk factors, and management and treatment. Severity of psoriasis was classified as mild, moderate, or severe. The studies cited in this review involved Chinese subjects. Results: The prevalence of psoriasis in the People's Republic of China ranged from 0.11% to 0.47%. Genetic and environmental factors played an important role in initiation and exacerbation of psoriasis. Results showed that psoriasis can occur at any age but is more common in young and middle-aged individuals and occurs more often in men and earlier in women. Psoriasis vulgaris accounted for 82.6%-97.1% of psoriasis patients. More than 90% of patients with psoriasis were classified as mild or moderately severe. Risk factors are numerous. Management and treatment was based on classification level. Conclusion:The prevalence of psoriasis in Chinese patients is lower than that in Caucasians. A cold and dry climate, bacterial infection, diet, and stress are important risk factors for developing psoriasis. There are a variety of management and treatment options available. As such, Chinese patients with psoriasis can receive effective, safe, and individualized treatment.

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Meta-analysis of psoriasis, cardiovascular disease, and associated risk factors

Cited by 275 publications

References 15 publications

Manual search approaches used by systematic reviewers in dermatology

Manual search approaches used by systematic reviewers in dermatology

Biologicals in the Treatment of Plaque Psoriasis: Drug Selection by Means of the SOJA Method

Epidemiology and treatment of psoriasis: a Chinese perspective

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