Meta-analysis of the association between MALAT1 rs619586 A>G polymorphism and cancer risk

Abstract

Objective This study aimed to systematically assess the effect of the metastasis associated lung adenocarcinoma transcript 1 ( MALAT1) long noncoding RNA rs619586 polymorphism on cancer risk. Methods We conducted a literature search of the PubMed, Embase, and China National Knowledge Internet databases to identify relevant studies, and calculated the pooled odds ratios (ORs) and 95% confidence intervals (CIs) for the retrieved studies using RevMan software. Results Nine eligible studies including 5968 cases and 7439 controls were included in the meta-analysis. The pooled results showed that MALAT1 rs619586 polymorphism was significantly associated with cancer risk [(AG + GG) vs. AA: OR = 0.88; GG vs. (AG + AA): OR = 0.64; GG vs. AA: OR = 0.63; AG vs. AA: OR = 0.91; G vs. A: OR = 0.87]. However, subgroup analyses based on ethnicity and cancer type showed significant associations between MALAT1 rs619586 polymorphism and cancer risk in Asians and for cancers other than hepatocellular carcinoma, but not for Caucasians and hepatocellular carcinoma. Conclusions MALAT1 rs619586 polymorphism may play a role in cancer risk. However, further studies are needed to confirm these findings.

Combined Impacts of Genetic Variants of Long Non-Coding RNA MALAT1 and the Environmental Carcinogen on the Susceptibility to and Progression of Oral Squamous Cell Carcinoma

“…To date, a number of SNPs in lncRNAs were found to be related to the development, progression, and prognosis of OSCC such as maternally expressed 3 ( MEG3 ) ( 13 ), phosphatase and tensin homolog pseudogene 1 ( PTENP1 ) ( 14 ), H19 ( 15 ), HOX transcript antisense RNA ( HOTAIR ) ( 16 ), and so on. Although MALAT1 SNPs such as rs619586 were reported to be associated with the risk or progression of several cancer types and expression of MALAT1 ( 17 ), little is known about the effects of polymorphisms of MALAT1 on the development and progression of OSCC, especially in Asian populations. In the present study, a case-control study in a Taiwanese population was performed to identify roles of MALAT1 SNPs in the risk and clinical characteristics of OSCC.…”

HMGA2 rs968697 T > C polymorphism is associated with the risk of colorectal cancer

“…Although the molecular etiology of CRC is still unknown, its onset is signi cantly associated with genetic variants. Single nueleotide polymorphism (SNP) is one of the most common genetic variants and involves altered cancer risk [9][10][11]. In the current study, we conducted a case-control study investigating the association between HMGA2 rs968697 polymorphism and CRC risk, and found that rs968697 C allele could reduce CRC risk compared with the T allele.…”

The Role of Long Non-Coding RNAs (lncRNAs) in Female Oriented Cancers

“…Since that overexpressed MALAT1 has been reported to be linked with a wide variety of lymphoid or solid tumors with high tumor progression and metastasis propensity and 1.5–10 fold relative upregulation based on type and stage of cancer [ 172 , 181 , 182 , 183 , 184 ]. Moreover, single nucleotide polymorphism in MALAT1, e.g., rs619586 A > G polymorphism, has also been witnessed to be linked with elevated cancer risks [ 185 ]. On the contrary, some recent studies have postulated the downregulated expression of MALAT1 in human breast and colorectal cancer, where its decreased expression is associated with lessened patient survival [ 176 , 186 ].…”