Meta-Analysis of white matter diffusion tensor imaging alterations in borderline personality disorder

Kelleher-Unger, Isaac; Tajchman, Zuzanna; Chittano, Gabriella; Vilares, Iris

doi:10.1016/j.pscychresns.2020.111205

Cited by 8 publications

(1 citation statement)

References 91 publications

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“…Thus, we endeavour to highlight the importance of investigating ED in these diseases both from a prognostic and diagnostic viewpoint, as well as for preventive and therapeutic interventions. Deficient or maladaptive ER has a strong neurobiological equivalent in these disorders, with documented brain alterations spanning multiple ER-associated circuits, including impairments in the functional and structural connectivity of limbic ER networks (34)(35)(36)(37)(38)(39)(40). Regions involved in ER that often exhibit alterations in EDD include the amygdala, the hippocampus, the dorsolateral (dlPFC), dorsomedial (dmPFC), ventrolateral (vlPFC), and ventromedial (vmPFC) prefrontal cortex, the anterior cingulate cortex (ACC), the inferior (IFG) and superior (SFG) frontal gyrus, alongside parietal and temporal regions, and the insula (41)(42)(43)(44)(45).…”

Section: Emotion Regulation and (Neuro)inflammation In Emotion Dysreg...mentioning

confidence: 99%

Inflammation and emotional regulation: a narrative review of evidence and mechanisms in emotional dysregulation disorders

Petruso¹,

Giff²,

Milano³

et al. 2023

Preprint

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Emotion dysregulation (ED) describes a difficulty with the modulation of which emotions are felt, as well as when and how these emotions are experienced or expressed. It is a focal overarching symptom in many severe and prevalent neuropsychiatric diseases, including bipolar disorders (BD), attention deficit and hyperactivity disorder (ADHD), and borderline personality disorder (BPD). In all these disorders, ED can manifest through symptoms of depression, anxiety, or affective lability. Considering the many similarities in symptoms between BD, ADHD, and BPD, a transdiagnostic approach is a promising lens of investigation. Mounting evidence supports the role of peripheral inflammatory markers and stress in the multifactorial aetiology and physiopathology of BD, ADHD, and BPD. Of note, neural circuits that regulate emotions appear particularly vulnerable to inflammatory insults and peripheral inflammation, which can impact the neuroimmune milieu of the central nervous system. Thus far, few studies have examined the link between ED and inflammation in BD, ADHD, and BPD. To our knowledge, no specific work has provided a critical comparison of the results from these disorders. To fill this gap in the literature, we review the known associations and mechanisms linking ED and inflammation in general, and clinically, in BD, ADHD, and BD. Our narrative review begins with an examination of the routes linking ED and inflammation, followed by a discussion of disorder-specific results accounting for methodological limitations and relevant confounding factors. Finally, we critically discuss both correspondences and discrepancies in the results and comment on potential vulnerability markers and promising therapeutic interventions.

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Section: Emotion Regulation and (Neuro)inflammation In Emotion Dysreg...mentioning

confidence: 99%

Inflammation and emotional regulation: a narrative review of evidence and mechanisms in emotional dysregulation disorders

Petruso¹,

Giff²,

Milano³

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

Resting-state functional magnetic resonance imaging alterations in borderline personality disorder: A systematic review

Shafie,

Shahmohamadi,

Cattarinussi

et al. 2023

Journal of Affective Disorders

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A machine-learning approach for differentiating borderline personality disorder from community participants with brain-wide functional connectivity

Lahnakoski,

Nolte,

Solway

et al. 2024

Journal of Affective Disorders

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Meta-Analysis of white matter diffusion tensor imaging alterations in borderline personality disorder

Cited by 8 publications

References 91 publications

Inflammation and emotional regulation: a narrative review of evidence and mechanisms in emotional dysregulation disorders

Inflammation and emotional regulation: a narrative review of evidence and mechanisms in emotional dysregulation disorders

Resting-state functional magnetic resonance imaging alterations in borderline personality disorder: A systematic review

A machine-learning approach for differentiating borderline personality disorder from community participants with brain-wide functional connectivity

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