Meta‐analysis: proton pump inhibitors vs. H₂‐receptor antagonists — their efficacy with antibiotics in Helicobacter pylori eradication

Abstract

SUMMARYBackground: It is unknown whether proton pump inhibitors are superior to H 2 -receptor antagonists in Helicobacter pylori eradication regimens. Aim: To perform a meta-analysis comparing the efficacy of both antisecretors when co-prescribed with antibiotics. Methods: Randomized clinical trials comparing proton pump inhibitors vs. H 2 -receptor antagonists with the same antibiotics were selected. Data sources included PubMed, the Cochrane Controlled Trials Register and abstracts from congresses up to January 2002. A meta-analysis was performed by combining the odds ratios. Results: Twenty studies fulfilled the inclusion criteria. In the intention-to-treat analysis, the mean eradication

Use of probiotics as an adjuvant to sequential H. pylori eradication therapy: impact on eradication rates, treatment resistance, treatment-related side effects, and patient compliance

“…The beneficial effects of Lactobacillus-and Bifidobacterium-containing probiotics on the eradication rate and the incidence of total side effects during H. pylori eradication therapy has also been reported in a meta-analysis by Wang et al (29) Hence, the eradication rates obtained in the placebo group in our cohort are consistent with the overall eradication rates reported previously in randomized trials (3,39,44), while the benefit of probiotic therapy on eradication rates also seems to be in agreement with data from studies on probiotics (18,25,29,30,39,(45)(46)(47), including Bifidobacterium (17,42,45).…”

A Meta-Analysis: Comparison of Esomeprazole and Other Proton Pump Inhibitors in Eradicating <i>Helicobacter pylori</i>

“…Eradication of H. pylori can relieve the symptoms of gastrointestinal disorder and decrease the recurrence of ulcers. Increased evidence has shown that PPIs are more effective than H 2 RAs in H. pylori eradication and gastric acid suppression [26, 27]. PPIs inhibit the H + ,K + -ATPase activity of the proton pump, the final pathway for secretion of hydrochloric acid by parietal cells, and alter intragastric pH.…”

Adverse Effects of Long-Term Proton Pump Inhibitor Therapy

“…This enzyme is responsible for the secretion of hydrogen ions in exchange for potassium in the gastric lumen, and its inhibition decreases gastric acidity. First introduced in the late 1980s, PPIs are the most potent inhibitors of gastric acid secretion available, with efficacy superior to histamine-2 receptor antagonists [1][2][3][4]. Because they effectively alleviate acid-peptic symptoms and facilitate healing of inflamed or ulcerated mucosa, current guidelines recommend their use for the treatment of gastroesophageal reflux disease (GERD), peptic ulcer prophylaxis in NSAID users, and Helicobacter pylori (H. pylori) eradication [5][6][7].…”