Meta-analytic connectivity modelling of functional magnetic resonance imaging studies in autism spectrum disorders

Goodwill, Alicia M.; Low, Li Tong; Fox, Peter T.; Fox, P. Mickle; Poon, Kenneth K.; Bhowmick, Sourav S.; Chen, S H Annabel

doi:10.1007/s11682-022-00754-2

Cited by 15 publications

(7 citation statements)

References 88 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…To our knowledge, there has been no prior report of our finding that FC between the fusiform gyrus and the frontal pole is attenuated in ASD. Amygdala-fusiform/cerebellar underconnectivity is related to social and nonsocial cognition in adults with ASD ( Goodwill et al. 2023 ).…”

Section: Discussionmentioning

confidence: 99%

Functional connectivity in autism spectrum disorder evaluated using rs-fMRI and DKI

Nagai,

Kirino,

Tanaka

et al. 2023

Cerebral Cortex

View full text Add to dashboard Cite

We evaluated functional connectivity (FC) in patients with adult autism spectrum disorder (ASD) using resting-state functional MRI (rs-fMRI) and diffusion kurtosis imaging (DKI). We acquired rs-fMRI data from 33 individuals with ASD and 33 healthy controls (HC) and DKI data from 18 individuals with ASD and 17 HC. ASD showed attenuated FC between the right frontal pole (FP) and the bilateral temporal fusiform cortex (TFusC) and enhanced FC between the right thalamus and the bilateral inferior division of lateral occipital cortex, and between the cerebellar vermis and the right occipital fusiform gyrus (OFusG) and the right lingual gyrus, compared with HC. ASD demonstrated increased axial kurtosis (AK) and mean kurtosis (MK) in white matter (WM) tracts, including the right anterior corona radiata (ACR), forceps minor (FM), and right superior longitudinal fasciculus (SLF). In ASD, there was also a significant negative correlation between MK and FC between the cerebellar vermis and the right OFusG in the corpus callosum, FM, right SLF and right ACR. Increased DKI metrics might represent neuroinflammation, increased complexity, or disrupted WM tissue integrity that alters long-distance connectivity. Nonetheless, protective or compensating adaptations of inflammation might lead to more abundant glial cells and cytokine activation effectively alleviating the degeneration of neurons, resulting in increased complexity. FC abnormality in ASD observed in rs-fMRI may be attributed to microstructural alterations of the commissural and long-range association tracts in WM as indicated by DKI.

show abstract

Section: Discussionmentioning

confidence: 99%

Functional connectivity in autism spectrum disorder evaluated using rs-fMRI and DKI

Nagai,

Kirino,

Tanaka

et al. 2023

Cerebral Cortex

View full text Add to dashboard Cite

show abstract

“…Recent findings from an updated meta-analysis about the activation of specific brain regions using MRI imaging support the potential involvement of the fusiform gyrus and the cerebellum in social cognition in ASD, with evidence of consistent hypo-activation of the left amygdala. Therefore, amygdala-fusiform/ cerebellar connectivity should be better studied in adults with ASD [14].…”

Section: Autism Spectrum Disordermentioning

confidence: 99%

“…ASD is a complex neurological and developmental disability also observed in some children affected by PHTS [11]. Many studies have been conducted exploring the cerebellum in different neurobiological settings, with evidence of some structural, genetic, functional and immunological alterations, from the autopsy findings of a lower Purkinje cell (PC) count in autistic patients [12, 13] to more recent neuroimaging findings, such as a meta‐analytic connectivity modelling of functional magnetic resonance imaging (MRI) [14].…”

Section: Introductionmentioning

confidence: 99%

Cerebellar phenotypes in germline PTEN mutation carriers

Gambini,

Ferrero,

Bulfamante

et al. 2024

Neuropathology Appl Neurobio

View full text Add to dashboard Cite

PTEN hamartoma tumour syndrome (PHTS) comprises different hereditary conditions caused by germline PTEN mutations, predisposing to the development of multiple hamartomas in many body tissues and also increasing the risk of some types of cancer.Cerebellar involvement in PHTS patients has been long known due to the development of a pathognomonic cerebellar hamartoma (known as dysplastic gangliocytoma of the cerebellum or Lhermitte‐Duclos disease). Recently, a crucial role of the cerebellum has been highlighted in the pathogenesis of autism spectrum disorders, now recognised as a phenotype expressed in a variable percentage of PHTS children. In addition, rare PTEN variants are indeed identified in medulloblastoma as well, even if they are less frequent than other germline gene mutations.The importance of PTEN and its downstream signalling enzymatic pathways, PI3K/AKT/mTOR, has been studied at different levels in both human clinical settings and animal models, not only leading to a better understanding of the pathogenesis of different disorders but, most importantly, to identify potential targets for specific therapies. In particular, PTEN integrity makes an important contribution to the normal development of tissue architecture in the nervous system, including the cerebellum. Thus, in patients with PTEN germline mutations, the cerebellum is an affected organ that is increasingly recognised in different disorders, whereas, in animal models, cerebellar Pten loss causes a variety of functional and histological alterations.In this review, we summarise the range of cerebellar involvement observed in PHTS and its relationships with germline PTEN mutations, along with the phenotypes expressed by murine models with PTEN deficiency in cerebellar tissue.

show abstract

“…Here are some brief examples of what has been discovered in these areas through neuroimaging research in ASD [74][75][76]. For example, studies have found differences in the size and shape of the amygdala, a brain region involved in emotional processing [77,78]. Other studies have found differences in the structure and connectivity of the prefrontal cortex, which is involved in social cognition and executive functioning [79,80].…”

Section: Neuroimaging Studies On Neurodevelopmental Disorders Such As...mentioning

confidence: 99%

Exploring the Frontiers of Neuroimaging: A Review of Recent Advances in Understanding Brain Functioning and Disorders

Yen

Lin

Chiang

2023

Life

View full text Add to dashboard Cite

Neuroimaging has revolutionized our understanding of brain function and has become an essential tool for researchers studying neurological disorders. Functional magnetic resonance imaging (fMRI) and electroencephalography (EEG) are two widely used neuroimaging techniques to review changes in brain activity. fMRI is a noninvasive technique that uses magnetic fields and radio waves to produce detailed brain images. An EEG is a noninvasive technique that records the brain’s electrical activity through electrodes placed on the scalp. This review overviews recent developments in noninvasive functional neuroimaging methods, including fMRI and EEG. Recent advances in fMRI technology, its application to studying brain function, and the impact of neuroimaging techniques on neuroscience research are discussed. Advances in EEG technology and its applications to analyzing brain function and neural oscillations are also highlighted. In addition, advanced courses in neuroimaging, such as diffusion tensor imaging (DTI) and transcranial electrical stimulation (TES), are described, along with their role in studying brain connectivity, white matter tracts, and potential treatments for schizophrenia and chronic pain. Application. The review concludes by examining neuroimaging studies of neurodevelopmental and neurological disorders such as autism spectrum disorder (ASD), attention deficit hyperactivity disorder (ADHD), Alzheimer’s disease (AD), and Parkinson’s disease (PD). We also described the role of transcranial direct current stimulation (tDCS) in ASD, ADHD, AD, and PD. Neuroimaging techniques have significantly advanced our understanding of brain function and provided essential insights into neurological disorders. However, further research into noninvasive treatments such as EEG, MRI, and TES is necessary to continue to develop new diagnostic and therapeutic strategies for neurological disorders.

show abstract

Meta-analytic connectivity modelling of functional magnetic resonance imaging studies in autism spectrum disorders

Cited by 15 publications

References 88 publications

Functional connectivity in autism spectrum disorder evaluated using rs-fMRI and DKI

Functional connectivity in autism spectrum disorder evaluated using rs-fMRI and DKI

Cerebellar phenotypes in germline PTEN mutation carriers

Exploring the Frontiers of Neuroimaging: A Review of Recent Advances in Understanding Brain Functioning and Disorders

Contact Info

Product

Resources

About