Meta-analytical definition and functional connectivity of the human vestibular cortex

Eulenburg, Peter zu; Caspers, Svenja; Roski, Christian; Eickhoff, Simon B.

doi:10.1016/j.neuroimage.2011.12.032

Cited by 368 publications

(383 citation statements)

References 49 publications

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“…Previous data 2,8 are not necessarily contradictory because these investigated larger infarctions of the MCA territory, whereas we focused on very small lesions exclusively affecting the IC. Obviously, cortical lesions outside the IC affecting the inferior frontal gyrus, the superior temporal gyrus, the peri-insular operculum, as well as white matter regions, such as the superior occipitofrontal fascicle or the inferior occipitofrontal fascicle, 2,3,8 might, in addition, be important for the perception of verticality. One possible explanation could be that larger lesions affecting more parts of the vestibular network might lead to a more severe tilt of SVV in a higher percentage of patients, or in other words, otolith deficits because of lesions restricted to the IC might be compensated by vestibular mechanisms achieved in other neighboring regions within the cortical vestibular network.…”

Section: Discussionmentioning

confidence: 99%

“…[1][2][3][4][5] However, it seems that small lesions exclusively affecting the IC might not be sufficient to cause vestibular otolith deficits, such as tilt of subjective visual vertical (SVV). 2 Presumably, because of the rareness of isolated insular infarctions, there are no data reporting about vestibular parameters in patients with isolated infarctions of the IC.…”

mentioning

confidence: 99%

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Insular Strokes Cause No Vestibular Deficits

Baier

Conrad²,

Eulenburg³

et al. 2013

Stroke

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Background and Purpose— In previous imaging studies, the posterior insular cortex (IC) was identified as an essential part for vestibular otolith perception and considered as a core region of a human vestibular cortical network. However, it is still unknown whether lesions exclusively restricted to the posterior IC suffice to provoke signs of vestibular otolith dysfunction. Thus, present data aimed to test whether patients with lesions restricted to the IC showed vestibular otolith dysfunction. Methods— We studied 10 acute unilateral stroke patients with lesions restricted to the IC which were tested for signs of vestibular otolith dysfunction, such as tilts of subjective visual vertical, out of 475 stroke patients. Results— None of the patients was with stroke exclusively affecting the IC-specified vertigo as a symptom. In addition, neither showed a deficit in the perception of verticality (subjective visual vertical tilts) nor showed any further vestibular otolith deficits, such as ocular torsion or skew deviation. Conclusions— It seems that lesions of the posterior IC might have to be combined with lesions of adjacent regions of the cortical and subcortical vestibular network to cause vestibular otolith deficits.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Insular Strokes Cause No Vestibular Deficits

Baier

Conrad²,

Eulenburg³

et al. 2013

Stroke

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show abstract

“…This approach was chosen to exclude trials associated with the perception Lopez et al (2012). The black circle shows the location of the core vestibular area in the meta-analysis by zu Eulenburg et al (2012) that was reported for the right hemisphere. D: average blood-oxygenation-level-dependent (BOLD) time course (ϮSE) in PIC in the vestibular experiment over the course of a caloric stimulation trial and the immediately following baseline trial.…”

Section: Vestibular Experimentmentioning

confidence: 99%

Vestibular and visual responses in human posterior insular cortex

Frank

Baumann

Mattingley

et al. 2014

Journal of Neurophysiology

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“…To this end, we extracted coordinates from ALE meta-analyses of peak activations in left and right SMA (Rehme et al, 2012), left and right PMd (Witt et al, 2008), left and right pre-SMA (Keuken et al, 2014), pars opercularis of the left and right IFG (Swick et al, 2011), and left and right motor putamen (Hardwick et al, 2012) (Table 1). The time course of the respective seed regions was subsequently extracted for each subject as the first eigenvariate of all gray-matter voxels located within a sphere of 8 mm-diameter centered at the seed voxel coordinate (zu Eulenburg et al, 2012). Linear Pearson's correlation coefficients were computed between the seed coordinate and the time course of every other voxel in the brain for each subject (zu Eulenburg et al, 2012).…”

Section: Data Analysesmentioning

confidence: 99%

“…The time course of the respective seed regions was subsequently extracted for each subject as the first eigenvariate of all gray-matter voxels located within a sphere of 8 mm-diameter centered at the seed voxel coordinate (zu Eulenburg et al, 2012). Linear Pearson's correlation coefficients were computed between the seed coordinate and the time course of every other voxel in the brain for each subject (zu Eulenburg et al, 2012). Only positive correlations were used to reconstruct the respective resting-state maps.…”

Section: Data Analysesmentioning

confidence: 99%

Functional resting-state connectivity of the human motor network: Differences between right- and left-handers

Pool¹,

Grefkes²,

Fink³

et al. 2014

Klin Neurophysiol

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Handedness is associated with differences in activation levels in various motor tasks performed with the dominant or non-dominant hand. Here we tested whether handedness is reflected in the functional architecture of the motor system even in the absence of an overt motor task. Using resting-state functional magnetic resonance imaging we investigated 18 right-and 18 left-handers. Whole-brain functional connectivity maps of the primary motor cortex (M1), supplementary motor area (SMA), dorsolateral premotor cortex (PMd), pre-SMA, inferior frontal junction and motor putamen were compared between right-and left-handers. We further used a multivariate linear support vector machine (SVM) classifier to reveal the specificity of brain regions for classifying handedness based on individual resting-state maps. Using left M1 as seed region, functional connectivity analysis revealed stronger interhemispheric functional connectivity between left M1 and right PMd in right-handers as compared to left-handers. This connectivity cluster contributed to the individual classification of right-and left-handers with 86.2% accuracy. Consistently, also seeding from right PMd yielded a similar handedness-dependent effect in left M1, albeit with lower classification accuracy (78.1%). Control analyses of the other resting-state networks including the speech and the visual network revealed no significant differences in functional connectivity related to handedness. In conclusion, our data revealed an intrinsically higher functional connectivity in right-handers. These results may help to explain that hand preference is more lateralized in right-handers than in left-handers. Furthermore, enhanced functional connectivity between left M1 and right PMd may serve as an individual marker of handedness.

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Meta-analytical definition and functional connectivity of the human vestibular cortex

Cited by 368 publications

References 49 publications

Insular Strokes Cause No Vestibular Deficits

Insular Strokes Cause No Vestibular Deficits

Vestibular and visual responses in human posterior insular cortex

Functional resting-state connectivity of the human motor network: Differences between right- and left-handers

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