2001
DOI: 10.4049/jimmunol.166.9.5422
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META-Controlled env-Initiated Transcripts Encoding Superantigens of Murine Mtv29 and Mtv7 and Their Possible Role in B Cell Lymphomagenesis

Abstract: Spontaneous germinal center (GC)-derived B cell lymphomas of SJL mice (RCS) transcribe a 1.8-kb Mtv-29 mRNA under control of the META-env promoter. The encoded vSAg29 stimulates syngeneic Vβ16+ CD4+ T cells, thereby acquiring T cell help necessary for RCS growth. Other strains of B cell lymphoma-prone mice include Mtv29+ C57L and MA/MyJ, and the Mtv29− Mtv7+-recombinant inbred strain, SW × J-1. The lymphomas of these mice produce similar mouse mtv-vSAg-encoding mRNA, as characterized by Northern blotting, PCR,… Show more

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Cited by 15 publications
(10 citation statements)
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“…tumor cells express a vSAg encoded by an endogenous retrovirus, one would expect that the tumor-specific Th cells would express the same TCR V␤ (13). All Th cell lines were restricted with respect to their V␤-chains; the predominant chain was V␤16 (Fig.…”
Section: Discussionmentioning
confidence: 99%
See 2 more Smart Citations
“…tumor cells express a vSAg encoded by an endogenous retrovirus, one would expect that the tumor-specific Th cells would express the same TCR V␤ (13). All Th cell lines were restricted with respect to their V␤-chains; the predominant chain was V␤16 (Fig.…”
Section: Discussionmentioning
confidence: 99%
“…Due to recognition of mouse mammary tumor virus-encoded vSAg in SJL lymphoma cells, there is skewing of TCR V␤ chains expressed on responding SJL T cells (13,25). Therefore, we determined whether the TCR V␤-chains of the tumor-responsive Th cell lines were skewed toward a particular V␤.…”
Section: Characterization Of Th Cell Linesmentioning
confidence: 99%
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“…If indeed such infection of human B and T cells can occur this may allow not only for the passage of MMTV to the breast as in the mouse but also to function as an etiological agent of disease in the lymphoid tissue itself. Spontaneous lymphomas arise in Ͼ90% of SJL mice by the age of 12 months and are of B-cell origin (58). The cells of these lymphomas stimulate T cells via expression of endogenous MMTV sag, and the cytokines produced by these activated T cells promote growth of the lymphomas.…”
Section: Discussionmentioning
confidence: 99%
“…B cell lymphomas of SJL/J mice depend for their growth on help from CD4 ϩ V␤16 ϩ T cells, which they stimulate by expressing an Mtv29-encoded proviral superantigen (vSAg29) (1,4). Unlike most other strains of MMTVs, which use promoter elements in the 5Ј LTR for superantigen transcription, the Mtv29 employs a promoter, META, in the env gene for the transcriptional initiation of mRNA encoding vSAg29 (2).…”
Section: Discussionmentioning
confidence: 99%