2008
DOI: 10.1534/genetics.107.082040
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Metabolic Changes Associated With Adaptive Diversification in Escherichia coli

Abstract: During a 1000-generation evolution experiment, two types of morphologically and kinetically distinct bacteria repeatedly diverged from a common ancestor in a fully sympatric seasonal environment containing glucose and acetate. To investigate the metabolic modifications associated with this adaptive diversification, we compared transcription profiles of the two derived types and the common ancestor. Both derived types share a suite of common metabolic changes that may represent adaptation to the environment pre… Show more

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Cited by 35 publications
(34 citation statements)
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References 34 publications
(44 reference statements)
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“…Assuming a single origin for each mutation, we infer that these shared mutations occurred before the two sequenced clones last shared a common ancestor. Phenotypically, the FS type represents a novel metabolic strategy, while the SS type is more similar to the ancestral strain [11],[27],[28],[30], and this difference is reflected in the underlying genetics. In all three populations, the FS clones are more genetically distant from the ancestor than the SS clones (paired t test, n  = 4 independent comparisons, two-tailed p  = 0.0008).…”
Section: Resultsmentioning
confidence: 99%
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“…Assuming a single origin for each mutation, we infer that these shared mutations occurred before the two sequenced clones last shared a common ancestor. Phenotypically, the FS type represents a novel metabolic strategy, while the SS type is more similar to the ancestral strain [11],[27],[28],[30], and this difference is reflected in the underlying genetics. In all three populations, the FS clones are more genetically distant from the ancestor than the SS clones (paired t test, n  = 4 independent comparisons, two-tailed p  = 0.0008).…”
Section: Resultsmentioning
confidence: 99%
“…From each population, we chose two large colonies with unambiguous SS growth profiles and two small colonies with unambiguous FS growth profiles for sequencing. For population 20, we used previously isolated clones [30], also from day 156 of the experiment. In this experiment, replicate populations were founded from isogenic lines of E. coli B and cultured in well-mixed condition for 183 d (∼1,230 generations) with daily (∼6.7 generations) transfers to fresh medium (Text S1).…”
Section: Methodsmentioning
confidence: 99%
“…In the present work, we use an experimental system in which initially isogenic populations of Escherichia coli B diversified into populations containing two different ecotypes, i.e. bacterial strains occupying different ecological niches, during 1200 generations of experimental evolution (Le Gac et al. 2008; Spencer et al.…”
Section: Introductionmentioning
confidence: 99%
“…They are named FS (Fast Switcher) and SS (Slow Switcher) in reference to the way they switch from the consumption of one carbon source to the other. SS is a fast glucose consumer and FS an efficient glucose and acetate consumer (Le Gac et al. 2008).…”
Section: Introductionmentioning
confidence: 99%
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