Metabolic connectivity as a predictor of surgical outcome in mesial temporal lobe epilepsy

Abstract

ObjectiveThe study investigated metabolic connectivity (MC) differences between patients with unilateral drug‐resistant mesial temporal lobe epilepsy (MTLE) with hippocampal sclerosis (HS) and healthy controls (HC), based on [18 F]‐fluorodeoxyglucose (FDG)‐PET data. We focused on the MC changes dependent on the lateralization of the epileptogenic lobe and on correlations with postoperative outcome.MethodsFDG‐PET scans of 47 patients with unilateral MTLE with histopathologically proven HS and 25 HC were included in the study. All the patients underwent a standard anterior temporal lobectomy and were more than two years after the surgery. MC changes were compared between the two HS groups (left HS, right HS) and HC. Differences between the metabolic network of seizure‐free and non‐seizure‐free patients after surgery were depicted afterward. Network changes were correlated with clinical characteristics.ResultsThe study showed widespread metabolic network changes in the HS patients as compared to HC. The changes were more extensive in right HS than in left HS. Unfavorable surgical outcomes were found in patients with decreased MC within the network including both the lesional and contralesional hippocampus, ipsilesional frontal operculum, and contralesional insula. Favorable outcomes correlated with decreased MC within the network involving both orbitofrontal cortices and the ipsilesional temporal lobe.SignificanceThere are major differences in the metabolic networks of left and right HS, with more extensive changes in right HS. The changes within the metabolic network could help predict surgical outcomes in patients with HS. MC may identify patients with potentially unfavorable outcomes and direct them to a more detailed presurgical evaluation.