Metabolic control quality and free radical activity in diabetic patients

Lipid Peroxidation by-Products and the Metabolic Syndrome

“…2 Results from Wierusz-Wysocka et al, 1995;Vijayalingam et al, 1996;Feillet-Coudray et al, 1999;Rábago-Velasco et al, 2000;Rizvi & Zaid, 2001;Seghrouchni et al, 2002;Dinçer et al, 2002;Dierckx et al, 2003;Duman et al, 2003;Pasaoglu et al, 2004;Memişoğullari & Bakan, 2004;Skrha et al, 2005;Kurtul et al, 2005;Ozdemir et al, 2005;Mahboob et al, 2005;Saxena et al, 2005;Sampathkumar et al, 2005;Kuppusamy et al, 2005;Lapolla et al, 2007;Sathiyapriya et al, 2007;Singhania et al, 2008;Jain et al, 2009;Nakhjavani et al, 2010;Narasimhan et al, 2010;Shinde et al, 2011;Huang et al, 2011;Bahadoran et al, 2011;Zhang et al, 2011;Pácal et al, 2011;Calabrese et al, 2011 andRasic-Milutinovic et al, 2012 Plasma GSH (mmol/g Hb)…”

“…Among α,β-unsaturated aldehydes, only MDA and to some extend HNE have been studied as oxidative stress biomarkers in diabetes, and they are indeed both increased up to 2-fold in both human (Figure 4) and animal models of type-2 diabetes (Wierusz-Wysocka et al, 1995;Dierckx et al, 2003). It has moreover been demonstrated that Type-2 diabetes duration is independently associated with increased levels of lipid peroxidation (Nakhjavani et al, 2010), and our group recently showed an increase in HHE concentration in type-2 diabetes patients, reinforcing existing evidence for the specific role of lipid aldehydes in insulin resistance.…”

Insulin Signaling Is Inhibited by Micromolar Concentrations of H2O2

“…Noninsulin-dependent diabetes mellitus (NIDDM) 1 is associated with accelerated production of oxygen-free radicals as well as a decreased scavenging of these proteins (2). A possible role of the accumulation of reactive oxidant species in the development of the late complications in diabetes has been discussed (5)(6)(7). Recently the question of a relationship between oxidative stress and insulin action (8) was raised, and it was suggested that changes in the physicochemical state of the plasma membrane and increases in intracellular calcium concentrations might be involved.…”

Mitochondria Function in Diabetes – From Health to Pathology – New Perspectives for Treatment of Diabetes-Driven Disorders

“…The role of glycaemic control on the pro-oxidant/antioxidant balance deserves special attention. Metabolic disturbances and oxidative stress seem to be closely related, improved glycaemic control being associated with a lowered pro-oxidant status (Wierusz-Wysocka et al, 1995). It was also evidenced that there is a relationship between oxidative stress and insulin resistance observed in diabetes.…”