Metabolic diseases: gout

Falasca, Gerald F.

doi:10.1016/j.clindermatol.2006.07.015

Cited by 114 publications

(122 citation statements)

References 100 publications

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“…1,2 The tophi cause inflammation, which leads to the symptoms of an acute gouty attack. 2,6 The presence of tophi can lead to soft tissue damage and destruction of the afflicted joint, which can cause the deformities associated with gout. 1 However, it is important to note that, while hyperuricaemia is a risk factor for gout, not all patients with hyperuricaemia develop gout.…”

Section: Pathophysiologymentioning

confidence: 99%

“…1 Hyperuricaemia causes an accumulation of monosodium urate crystals, which are deposited in the supersaturated body fluids and then are deposited in tissues and around joints during the asymptomatic hyperuricaemic gout stage. 1,2,6 The monosodium urate crystals form tophi. 1,2 The tophi cause inflammation, which leads to the symptoms of an acute gouty attack.…”

Section: Pathophysiologymentioning

confidence: 99%

“…7 Prevalence A 4.1% prevalence of hyperuricaemia was found in a previous study in people older than 75 years. 2 However, care should be taken when comparing prevalence rates of gout in different studies, as there are so many variables to take into consideration. 8 Examples of these variables include diagnostic criteria, sample size and even seasonal changes in levels of serum uric acid.…”

Section: Incidence Of Gout In Various Populationsmentioning

confidence: 99%

“…various types of meat, seafood and certain vegetables, ethanol intake, obesity and the use of diuretics and lowdose aspirin. 2,3 Gender is also a risk factor, due to the greater prevalence of gout in men than in women. 1 The peak incidence of gout occurs between the ages of 30 and 50 years, and the prevalence continues to increase with age.…”

Section: Introductionmentioning

confidence: 99%

“…It has been said that we are currently in the middle of the third epidemic. 2 The search for new gout treatments has increased considerably due to the large increase in the incidence of gout, as well as the renal and cardiovascular consequences of this disease. 6 …”

Section: Introductionmentioning

confidence: 99%

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Hyperuricaemia and gout: A review

Kopke

Greeff

2010

South African Family Practice

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Gout is a painful, inflammatory disease that affects more men than women. The incidence of gout has increased substantially over the past few decades, as evidenced by information from the Rochester project. Some of the risk factors for the development of gout include: increased ethanol intake, high dietary purine consumption, obesity and the use of certain drugs, such as diuretics. Another important risk factor for the development of gout is hyperuricaemia.Hyperuricaemia results from an imbalance between the rate of production and excretion of uric acid in the body. An excess of uric acid thus builds up in the body, supersaturating body fluids and leading to the formation of monosodium urate crystals. These crystals accumulate in tissue and around joints, leading to an acute gout attack.Gout can be divided into four phases, namely asymptomatic hyperuricaemia, acute gout attacks or recurrent gout, intercritical gout and chronic tophaceous gout. Various treatment options are available for gout, and the treatment for each gout patient is determined by the stage of the disease. Non-steroidal anti-inflammatory drugs (NSAIDs), corticosteroids, corticotropin and colchicine are used for the treatment of acute gout attacks. Allopurinol and probenecid are used for long-term hypouricaemic therapy, while NSAIDs and colchicine are prescribed for the prophylaxis of future gout attacks.All of these treatments have side effects, ranging from mild to life-threatening in nature. There is a need for novel gout therapies that have fewer side effects but are still as effective.Peer reviewed.

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Section: Pathophysiologymentioning

confidence: 99%

Section: Pathophysiologymentioning

confidence: 99%

Section: Incidence Of Gout In Various Populationsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Hyperuricaemia and gout: A review

Kopke

Greeff

2010

South African Family Practice

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Deposition and Storage

2015

Atlas of Dermatopathology

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Wearable and Miniaturized Sensor Technologies for Personalized and Preventive Medicine

Tricoli

Nasiri

2017

Adv Funct Materials

290

204

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The unprecedented medical achievements of the last century have dramatically improved our quality of life. Today, the high cost of many healthcare approaches challenges their long‐term financial sustainability and translation to a global scale. The convergence of wearable electronics, miniaturized sensor technologies, and big data analysis provides novel opportunities to improve the quality of healthcare while decreasing costs by the very early stage detection and prevention of fatal and chronic diseases. Here, some exciting achievements, emerging technologies, and standing challenges for the development of non‐invasive personalized and preventive medicine devices are discussed. The engineering of wire‐ and power‐less ultra‐thin sensors on wearable biocompatible materials that can be placed on the skin, pupil, and teeth is reviewed, focusing on common solutions and current limitations. The integration and development of sophisticated sensing nanomaterials are presented with respect to their performance, showing exemplary implementations for the detection of ultra‐low concentrations of biomarkers in complex mixtures such as the human sweat and breath. This review is concluded by summarizing achievements and standing challenges with the aim to provide directions for future research in miniaturized medical sensor technologies.

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Metabolic diseases: gout

Cited by 114 publications

References 100 publications

Hyperuricaemia and gout: A review

Hyperuricaemia and gout: A review

Deposition and Storage

Wearable and Miniaturized Sensor Technologies for Personalized and Preventive Medicine

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