Metabolic engineering of non-conventional yeasts for construction of the advanced producers of biofuels and high-value chemicals

Sibirny, Andriy А.

doi:10.1016/j.bbadva.2022.100071

Cited by 5 publications

(4 citation statements)

References 102 publications

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“…Units Inoculum (g•L −1 ) Fructose Glucose Xylose Ethanol production from glucose, fructose, and xylose follows different pathways (Figure 4) [53]. The glucose and fructose fermentations produce ethanol through the Embden-Meyerhof-Parnas pathway (glycolysis reactions).…”

Section: Parametersmentioning

confidence: 99%

“…Furthermore, the fermentation of xylose using H. Polymorpha was reported to be dependent on the proper functioning of its peroxisomes, transadolases, and cytosolic transketolases. This dependency would be not necessary for glucose or fructose fermentation [52][53][54][55]. 4) [53].…”

Section: Parametersmentioning

confidence: 99%

“…This dependency would be not necessary for glucose or fructose fermentation [52][53][54][55]. 4) [53]. The glucose and fructose fermentations produce ethanol through the Embden-Meyerhof-Parnas pathway (glycolysis reactions).…”

Section: Parametersmentioning

confidence: 99%

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Fermentation of Sugar by Thermotolerant Hansenula polymorpha Yeast for Ethanol Production

Karim,

Martínez-Cartas,

Cuevas-Aranda

2024

Fermentation

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Hansenula polymorpha is a non-conventional and thermo-tolerant yeast that is well-known for its use in the industrial production of recombinant proteins. However, research to evaluate this yeast’s potential for the high-temperature fermentation of sugar to produce alcohols for biofuel applications is limited. The present work investigated a wild-type H. polymorpha strain (DSM 70277) for the production of ethanol at a temperature of 40 °C under limited oxygen presence by using a batch fermentation reactor. Fermentation experiments were performed using three types of sugar (glucose, fructose, xylose) as substrates with two initial inoculum concentrations (1.1 g·L−1 and 5.0 g·L−1). The maximum specific growth rates of H. polymorpha yeast were 0.121–0.159 h−1 for fructose, 0.140–0.175 h−1 for glucose, and 0.003–0.009 h−1 for xylose. The biomass volumetric productivity was 0.270–0.473 g·L−1h−1 (fructose), 0.185–0.483 g·L−1h−1 (glucose), and 0.001–0.069 g·L−1h−1 (xylose). The overall yield of ethanol from glucose (0.470 g·g−1) was higher than that from fructose (0.434 g·g−1) and xylose (0.071 g·g−1). The H. polymorpha yeast exhibited different behavior and efficacy regarding the use of glucose, fructose, and xylose as substrates for producing ethanol. The present knowledge could be applied to improve the fermentation process for valorization of waste biomass to produce bioethanol.

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Section: Parametersmentioning

confidence: 99%

Section: Parametersmentioning

confidence: 99%

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Fermentation of Sugar by Thermotolerant Hansenula polymorpha Yeast for Ethanol Production

Karim,

Martínez-Cartas,

Cuevas-Aranda

2024

Fermentation

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“…Included among the authors are recipients of various prestigious international awards, including the Gregorio Weber Award in Biological Fluorescence and the Hans Neurath Award in Protein Science. The submissions cover a wide area of subjects, ranging from regulation of translation [ 3 , 4 ] and gene activation [5] to protein-membrane interactions [ 6 , 7 ] and cellular signaling [ 2 , [8] , [9] , [10] , [11] ]; from biotechnology [ 12 , 13 ]to structure-function studies of proteins [14] , [15] , [16] , nucleic acids [17] carbohydrates [18] and phosphoglycolipids [19] . The contributions to this issue also cover a broad spectrum of experimental and theoretical approaches, including photochemistry and biochemistry of proton transfer reactions [ 20 , 21 ], quantum chemical modeling [17] and theoretical and experimental exploration of complex spectroscopic responses of amyloids [6] .…”

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confidence: 99%