Metabolic features associated with positivity to ZnT8 autoantibody in sub-Saharan African young-onset diabetes patients

Mbanya, Armand; Ngandeu, A.; Kamwa, Vicky; Donfack, Oliver T.; Lontchi, É.; Leke, Rose G. F.; Mbanya, J.C.; Sobngwi, Eugène

doi:10.1016/j.diabet.2015.12.002

Cited by 6 publications

(5 citation statements)

References 10 publications

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“…Mbanya et al [ 23 ] showed that the ZnT8A-positive patients with diabetes had significantly lower BMI z scores than the ZnT8A-negative ones. In the present study, the ZnT8A-positive type 1 diabetics had lower BMI z scores than the ZnT8A-negative type 1 diabetics, but not significantly.…”

Section: Discussionmentioning

confidence: 99%

Zinc transporter 8 autoantibody in the diagnosis of type 1 diabetes in children

2020

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Background: Type 1 diabetes (T1D) is an organ-specific autoimmune disease related to the autoimmune response against pancreatic β-cells. Zinc transporter 8 (ZnT8), an islet-specific gene product localized to the β-cell insulin granule, was recently identified as an autoantigen in T1D.Purpose: To evaluate the use of ZnT8 autoantibody (ZnT8A) for diagnosing T1D.Methods: This case-control study was conducted at Dr. Soetomo General Hospital, Surabaya, Indonesia, from March to May 2019. Children younger than 18 years of age with T1D based on the International Society for Pediatric and Adolescent Diabetes guideline and healthy controls were included. We measured ZnT8A level using enzyme-linked immunosorbent assay (cutoff value, 0.315).Results: There were 30 children with T1D (50.0% boys; mean age, 11.3±3.7 years) and 18 healthy controls (44.4% boys; mean age, 8.3±3.1 years); 1 patient in each group was Madurese, while the others were Javanese. Twenty-two of 30 subjects with T1D (73.3%) tested positive for ZnT8A compared to 5 of 18 controls (27.8%) (<i>P</i>=0.02; odds ratio, 7.15; 95% confidence interval, 1.93–26.52). When ZnT8A-positive and -negative T1D cases were compared, no differences were detected in age at diagnosis, duration of diabetes, presence of ketoacidosis, body mass index, glycosylated hemoglobin concentration, or C-peptide concentrations.Conclusion: ZnT8A may be useful in the diagnosis of T1D.

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Section: Discussionmentioning

confidence: 99%

Zinc transporter 8 autoantibody in the diagnosis of type 1 diabetes in children

2020

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“…Blood was sampled through the left antecubital vein. A priming dose of insulin was given over the first 10 minutes followed by a constant infusion rate of 80 mU/m 2 /min up to the 120th minute [ 12 , 13 ]. The 10% dextrose solution was infused as from the 11th minute at variable rates modifiable every 5 minutes using an infusion pump (IVAC Corporation, Model 598, San Diego, California) with the aim of maintaining capillary blood sugar levels at 5.5 ± 0.5 mmol/L.…”

Section: Methodsmentioning

confidence: 99%

The Relationship between Adiposity and Insulin Sensitivity in African Women Living with the Polycystic Ovarian Syndrome: A Clamp Study

Doh

Mbanya

Kemfang-Ngowa

et al. 2016

International Journal of Endocrinology

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Objectives. We aimed to assess the variation of insulin sensitivity in relation to obesity in women living with PCOS in a sub-Sahara African setting. Methods. We studied body composition, insulin sensitivity, and resting energy expenditure in 14 PCOS patients (6 obese and 8 nonobese) compared to 10 matched nonobese non-PCOS subjects. Insulin sensitivity was assessed using the gold standard 80 mU/m2/min euglycemic-hyperinsulinemic clamp and resting energy expenditure was measured by indirect calorimetry. Results. Insulin sensitivity adjusted to lean mass was lowest in obese PCOS subjects and highest in healthy subjects (11.2 [10.1–12.4] versus 12.9 [12.1–13.8] versus 16.6 [13.8–17.9], p = 0.012); there was a tendency for resting energy expenditure adjusted for total body mass to decrease across the groups highest in obese PCOS subjects (1411 [1368–1613] versus 1274 [1174–1355] versus 1239 [1195–1454], p = 0.306). Conclusion. In this sub-Saharan population, insulin resistance is associated with PCOS per se but is further aggravated by obesity. Obesity did not seem to be explained by low resting energy expenditure suggesting that dietary intake may be a determinant of the obesity in this context.

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“…Despite the important contribution of cardiomyopathy to cardiovascular injury and cardiac failure in diabetic patients, only a few studies have examined its prevalence in T2DM patients in Africa. Mbanya et al reported a 40% and 55% prevalence of LV hypertrophy and systolic dysfunction in 40 normotensive T2DM patients in Cameroon 77 . Two recent studies from Nigeria reported sub-clinical cardiomyopathy by showing 72% and 65.6% LV diastolic dysfunction and significantly increased LV mass in normotensive T2DM patients 78,79 .…”

Section: Africamentioning

confidence: 98%

Diabetes and complications of the heart in Sub-Saharan Africa: An urgent need for improved awareness, diagnostics and management

Glezeva

Chisale

McDonald

et al. 2018

Diabetes Research and Clinical Practice

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Type 2 diabetes mellitus is no longer a disease of high income countries but a global health pandemic. With the continued and rapid increase in its prevalence worldwide it is forecasted that diabetes will be a leading cause of morbidity and mortality. A major concern stems from its role in development and progression of cardiovascular disease, including cardiac dysfunction and heart failure. Within low- and middle-income areas such as Sub-Saharan Africa the burden of diabetes is already significant driven by many factors, including, socioeconomic (urbanisation), nutritional (high-calorie "western-diet", obesity) and lifestyle (physical inactivity) changes. Insufficient economic and community resources, poor health care system development and chronic disease management, poor education, and a lack of preventative and diagnostic measures further aggravate the severity of the diabetes problem. This review outlines the burden of type 2 diabetes mellitus in Sub-Saharan Africa and highlights the need for improved community health care and regulations to reduce its epidemiological spread and devastating impact on health.

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Metabolic features associated with positivity to ZnT8 autoantibody in sub-Saharan African young-onset diabetes patients

Cited by 6 publications

References 10 publications

Zinc transporter 8 autoantibody in the diagnosis of type 1 diabetes in children

Zinc transporter 8 autoantibody in the diagnosis of type 1 diabetes in children

The Relationship between Adiposity and Insulin Sensitivity in African Women Living with the Polycystic Ovarian Syndrome: A Clamp Study

Diabetes and complications of the heart in Sub-Saharan Africa: An urgent need for improved awareness, diagnostics and management

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