Metabolic Features in Psoriasis

Ganzetti, Giulia; Campanati, Anna; Liberati, Giulia; Offidani, Annamaria

doi:10.5772/26129

Cited by 3 publications

(11 citation statements)

References 44 publications

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“…This seems noteworthy, as excess liver fat promotes hepatic insulin resistance and NAFLD is a recognized risk factor for diabetes. 10 Collectively, these results strongly support the fact that obesity and adipose tissue may potentially initiate and guide many of the known inflammatory mechanisms behind the pathogenesis of psoriasis and, finally, could lead to developing diabetes mellitus type 2.…”

Section: Discussionmentioning

confidence: 60%

<p>Small Molecules, Big Promises: Improvement of Psoriasis Severity and Glucidic Markers with Apremilast: A Case Report</p>

Lanna

Cesaroni

Mazzilli

et al. 2019

DMSO

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Psoriasis is a common inflammatory skin condition frequently associated with cardiometabolic diseases such as diabetes. Indeed, the state of systemic inflammation typical of psoriasis leads to an increase in the level of IL-1, IL-6 and TNF-alpha which may cause a reduced sensitivity to insulin and, ultimately, can lead to type 2 diabetes mellitus. Particularly, the derangement of PDE4-cAMP signaling has a critical role in disordered glucose and lipid metabolism. Apremilast, as a selective inhibitor of PDE4-cAMP signalling, represents an innovative therapeutic strategy for psoriasis. Here, we report a case of a patient affected by psoriasis and diabetes, whoafter using Apremilastimproved his glucose metabolism as well as his need of anti-diabetic drugs and his psoriasis. This suggests that, in addition to its role against psoriasis, Apremilast may even act as a metabolic modulator.

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Section: Discussionmentioning

confidence: 60%

<p>Small Molecules, Big Promises: Improvement of Psoriasis Severity and Glucidic Markers with Apremilast: A Case Report</p>

Lanna

Cesaroni

Mazzilli

et al. 2019

DMSO

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“…UV therapy, leveraging UV light, addresses conditions like psoriasis and AD, whereas visible light therapy uses certain wavelengths within the visible spectrum to treat ailments such as acne and seasonal affective disorder (SAD). UV phototherapy, in particular, provides a localized treatment that circumvents the systemic side effects associated with more profound immunosuppression, cementing its role in dermatological treatment, especially with the advent of biological agents [ 19 - 21 ].…”

Section: Reviewmentioning

confidence: 99%

“…This alteration inhibits DNA transcription machinery, disrupts the cell cycle, and results in growth arrest in human fibroblasts and epidermal cells, a process known as the phototype I reaction. In essence, the direct absorption of photons by DNA can lead to structural changes in the DNA molecule, ultimately disrupting cell division in response to UV radiation [ 19 , 21 , 23 ].…”

Section: Reviewmentioning

confidence: 99%

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A Comprehensive Review of Phototherapy in Atopic Dermatitis: Mechanisms, Modalities, and Clinical Efficacy

Molla

2024

Cureus

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This literature review explores atopic dermatitis and its management, with a focus on phototherapy as a treatment modality. The primary objectives are to elucidate the pathophysiological mechanisms, clinical manifestations, diagnostic criteria, and epidemiology of atopic dermatitis. Additionally, it seeks to explain phototherapy mechanisms, different modalities, and other therapeutic approaches. In this review, we comprehensively examine atopic dermatitis by synthesizing findings from diverse sources over the past 20 years. We investigate the epidemiology, pathophysiology, clinical manifestations, diagnostic criteria, and role of phototherapy in treatment. We conduct thematic analysis, compare phototherapy modalities, consider contextual factors, and integrate patient perspectives while upholding ethical considerations. Limitations include potential publication bias, language barriers, temporal constraints, subjectivity, and limited generalizability. Atopic dermatitis has a complex pathogenesis and can be managed with diverse modalities. Phototherapy emerges as an effective and safe treatment, particularly when other therapies prove ineffective.

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“…Patients may present, next to the red scaly lesions, with obesity, non-alcoholic fatty liver disease, diabetes and cardiovascular disease (CVD) (1,2). Moreover, psoriasis (PsO), an immune-mediated inflammatory disease (IMID), may coexist with other IMIDs such as psoriatic arthritis (PsA), Crohn's disease, rheumatoid arthritis and ankylosing spondylitis (3,4).…”

Section: Background and Questions Addressedmentioning

confidence: 99%