Metabolic impact on serum levels of complement component 3 in Japanese patients

Abstract

The aim of this study was to explore the association between the serum concentration of complement component 3 (C3) and a variety of metabolic parameters. The study involved 125 patients in our outpatient clinic. Anthropometric and clinical laboratory data were collected and statistical associations between the serum concentration of C3 and other parameters were evaluated in a cross-sectional as well as a prospective manner. A group of male patients with metabolic syndrome (Mets, n=35) were characterized by marked increase in serum concentrations of C3, body mass index (BMI), waist circumference, hemoglobin (Hb) A1c, insulin resistance (HOMA-IR), triglyceride, uric acid, urinary protein, and Hb. In a one-way analysis of variance of all subjects, the serum concentration of C3 was significantly elevated as the number of items of complying with the Mets diagnostic criteria increased. In 60 of 125 patients who did not have diabetes and were given anti-lipogenetic medication, the serum concentration of C3 showed significant positive associations with serum levels of CH50, insulin, HOMA-IR, total cholesterol, hematocrit, LDL-c, C4, Hb, triglyceride, BMI, and albumin. In a prospective follow-up evaluation (n=35), there was a significant positive association between DeltaC3 (the second concentration of serum C3 minus the first concentration of serum C3)and DeltaHOMA-IR (the second concentration of HOMA-IR minus the first concentration of HOMA-IR). In conclusion, in Japanese patients, there is evidence implicating C3 concentration as a marker of Mets coinciding with insulin resistance.

Impact of Body Mass Index on Progression of IgA Nephropathy Among Japanese Patients

“…A complement cascade is activated within the sites of connective tissues and atherosclerotic lesions . The authors have previously demonstrated that male patients with metabolic syndrome showed higher concentrations of serum C3, and C3 is closely related to insulin resistance . In IgAN patients, we also have indicated that the serum C3 level is closely related to nutritional status, metabolic syndrome, and the prognosis of the patients .…”

Complement Component 3 Is Associated with Metabolic Comorbidities in Older HIV-Positive Adults

“…16,17 The complement system has been hypothesized to play a role in the development of MetS and may be involved in deranged postprandial lipid metabolism in this setting. [18][19][20] C3 may play a particularly strong role in HIV-associated cardiometabolic disease. In this study, C3 was higher in HIV + patients with MetS but was not correlated with other inflammatory biomarkers, potentially indicating a unique role for C3 in this population.…”

Decreased Circulating C3 Levels and Mesangial C3 Deposition Predict Renal Outcome in Patients with IgA Nephropathy

“…Recent previous studies showed that increased complement levels were related to extreme adiposity and insulin resistance [33], [34]. On the contrary, a few studies suggested complement activation in patients with very low BMI such as anorexia nervosa [35]–[37].…”