Metabolic labeling and targeted modulation of dendritic cells

Wang, Hua; Sobral, Miguel C.; Zhang, David; Cartwright, Adam N.R.; Li, Aileen Weiwei; Dellacherie, Maxence O.; Tringides, Christina M.; Koshy, Sandeep T.; Wucherpfennig, Kai W.; Mooney, David J.

doi:10.1038/s41563-020-0680-1

Cited by 127 publications

(93 citation statements)

References 51 publications

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“…Labeling particles with key receptors allows for the manipulation and amplification of the desired immune responses. [ 206,207 ] Since COFs can load large amount of material, loading COFs with antigens can mimic vaccines by generating a depot effect, without inducing the known toxic effects of adjuvants, as seen in traditional vaccines. [ 207,208 ]…”

Section: Future Outlook: Application Of Cofs In Immune Engineeringmentioning

confidence: 99%

Covalent Organic Frameworks for Biomedical Applications

Esrafili

Wagner

Inamdar

et al. 2021

Adv Healthcare Materials

133

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Covalent organic frameworks (COFs) are porous organic polymeric materials that are composed of organic elements and linked together by the thermodynamically stable covalent bonds. The applications of COFs in energy sector and drug delivery are afforded because of the desirable properties of COFs, such as high stability, low density, large surface area, multidimensionality, porosity, and high‐ordered crystalline structure expanded. In this review COFs are reviewed, from the perspective of different types of reported COFs, different methods for their synthesis, and their potential applications in the biomedical field. The main goal of this review is to introduce COFs as a biomaterial and to identify specific advantages of different types of COFs that can be exploited for specialized biomedical applications, such as immune engineering.

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Section: Future Outlook: Application Of Cofs In Immune Engineeringmentioning

confidence: 99%

Covalent Organic Frameworks for Biomedical Applications

Esrafili

Wagner

Inamdar

et al. 2021

Adv Healthcare Materials

133

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“…[ 115–117 ] Wang et al described a way to concentrate DCs with GM‐CSF followed by ultrasound‐triggered release of azido‐sugar nanoparticles for covalently capturing of dibenzocyclooctyne‐bearing agents in vivo via click chemistry. [ 118 ] This hydrogel materials recruited a high number of azide positive DCs with 2.5× more ovalbumin positive DCs in the draining lymph nodes than control group, suggesting that this novel method substantially promoted antigen uptake capability. This class of DCs‐target approach was also instrumental in amplifying therapeutic performance of human papillomavirus (HPV) cancer vaccine with an almost complete tumor inhibition.…”

Section: Hydrogels To Enhance Cancer Immunotherapymentioning

confidence: 99%

Hydrogels for Engineering the Immune System

Shou

Tay

2021

Advanced NanoBiomed Research

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Human immune system has evolved as one of the most powerful defense systems to protect against invading pathogens and mutated cells. However, when persistent immune suppression or activation occurs, it can lead to adverse, chronic physiological effects including cancer and arthritis. Hydrogels are soft materials that can be engineered to modulate immune responses through controlled biomolecule release/adsorption, regeneration of lymphoid tissues, and enhanced antigen presentations. This is achieved by programming hydrogels to exhibit optimal properties such as porosity, biodegradability, and biocompatibility to interface seamlessly with the immune system. Herein, recent innovations and future challenges are described using programmable hydrogels to regenerate the lymphatic system, modulate inflammation, and enhance cancer immunotherapy. Key properties of hydrogels are also highlighted for engineering the immune system and techniques to characterize these properties.

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“…However, targeting immunotherapies specifically to DCs in order to initiate this cascade is a substantial challenge 2 . Towards this goal, Hua Wang and colleagues 3 developed an approach, published in Nature Materials, to track and modulate DCs, enhancing their ability to promote anti-tumour T-cell response. The researchers engineered an injectable biomaterial containing immune signals to recruit DCs for chemical labelling with azide functional groups 3 .…”

mentioning

confidence: 99%

“…Towards this goal, Hua Wang and colleagues 3 developed an approach, published in Nature Materials, to track and modulate DCs, enhancing their ability to promote anti-tumour T-cell response. The researchers engineered an injectable biomaterial containing immune signals to recruit DCs for chemical labelling with azide functional groups 3 . After migration of DCs to lymph nodes, tissues where DCs coordinate T-cell response against cancer and infection, the labelled DCs were specifically targeted with tumour antigens and immunomodulators functionalized with the azide binding group, dibenzocyclooctyne (DCBO).…”

mentioning

confidence: 99%