Metabolic parameters and dry matter intake of ewes treated with butaphosphan and cyanocobalamin in the early postpartum period

Pereira, Rubens Alves; Fensterseifer, S.R.; Barcelos, Vinícius Boechel; Martins, Charles Ferreira; Schneider, Augusto; Schmitt, Eduardo; Pfeifer, Luiz Francisco Machado; Pino, Francisco Augusto Burkert Del; Corrêa, Márcio Nunes

doi:10.1016/j.smallrumres.2013.05.016

Cited by 20 publications

(16 citation statements)

References 26 publications

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“…This study was designed to develop a sensitive analytical method for the pharmacokinetic analysis of butaphosphan (BTP). Although BTP has widely been prescribed to attenuate stress symptoms in both domestic and aquaculture sectors (Deniz et al 2009;Fürll et al 2006;Fürll et al 2010;Mechesso et al 2019;Pereira et al 2013aPereira et al , 2013bRolling et al 2010;Seo et al 2019;Tabeleão et al 2017;Van der Staay et al 2007), analytical procedures have not well been described. In addition, understanding the pharmacokinetic characteristics of a drug is crucial to estimate the onset, duration, and termination of biological activities (Benez 1984).…”

Section: Discussionmentioning

confidence: 99%

“…Additionally, the drug is helpful in cows recovering from surgical procedures (Fürll et al 2006;Fürll et al 2010). In sheep stressed due to drug treatments, BTP improved appetite and metabolic adjustments (Pereira et al 2013b). In piglets, an assessment of cortisol levels and behavioral changes has indicated reduced social stress induced by co-housing with unfamiliar individuals (Van der Staay et al 2007).…”

Section: Introductionmentioning

confidence: 99%

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Establishment of an analytical method for butaphosphan (BTP), a stress-attenuating agent, and its application in the preliminary pharmacokinetic evaluation of residues in olive flounder Paralichthys olivaceus

et al. 2020

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Background: Butaphosphan (BTP) has recently been introduced into the Korean aquaculture sector as a stressattenuating agent. In this study, a sensitive chemical analytical method was established for the detection of BTP in the olive flounder (Paralichthys olivaceus) tissues. Methods: Utilizing a method employing liquid chromatography coupled with tandem mass spectrometry (LC-MS/ MS), detection sensitivity, specificity, and precision were satisfactorily established. Temporal changes in the BTP plasma and muscle concentrations were assessed after a single intramuscular injection of BTP (50 and 150 mg/kg) to the olive flounder maintained at 13°C or 22°C.Results: High BTP plasma levels were achieved immediately after the injection, and the drug was rapidly eliminated. Additionally, plasma BTP levels were markedly dependent on the elimination rate, which, in turn, seemed dependent on the water temperature, with the drug elimination half-life and mean residence time significantly shorter at 22°C than 13°C. Overall, muscle BTP levels were markedly lower than the plasma levels. Notably, muscle levels were not influenced by water temperatures. Muscle BTP concentrations were used to estimate the necessary withdrawal period for drugs used in food fish, with BTP levels maintained far below the possible hazardous limit. Conclusions: In conclusion, the established LC-MS/MS method can be used for BTP residue detection with high sensitivity and reproducibility.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Establishment of an analytical method for butaphosphan (BTP), a stress-attenuating agent, and its application in the preliminary pharmacokinetic evaluation of residues in olive flounder Paralichthys olivaceus

et al. 2020

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“…Diversos trabalhos já avaliaram os efeitos do butafosfan e da cianocobalamina sobre marcadores do metabolismo energético e produção em vacas leiteiras (Fürll et al 2010, Pereira et al 2013a. Entretanto, esse é o primeiro estudo que avalia a influência do butafosfan e da cianocobalamina sobre o índice de funcionalidade hepática (IFH) de vacas leiteiras primíparas após o parto.…”

Section: Discussionunclassified

Butafosfan e cianocobalamina: estratégia para melhorar a funcionalidade hepática de vacas leiteiras primíparas

Antunes¹,

Pereira²,

Montagner³

et al. 2018

Revista Brasileira De Ciência Veterinária

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O objetivo deste estudo foi avaliar os efeitos do butafosfan isolado ou associado à cianocobalamina sobre marcadores do metabolismo energético, mineral e inflamatório, produção de leite e índice de funcionalidade hepática (IFH) de vacas leiteiras primíparas. Vinte e três vacas da raça Holandês foram aleatoriamente distribuídas em três grupos experimentais: Grupo Combinação (COM, n = 8), que recebeu 100 mL da combinação de butafosfan+cianocobalamina; Grupo Butafosfan (BUT, n = 8), que recebeu 100 mL de solução aquosa de Butafosfan; e Grupo Controle (CTL, n = 7), que recebeu 100 mL de solução fisiológica 0,9%. Todos os animais recebram 5 doses subcutâneas de 20 mL a cada 24 horas, iniciando logo após o parto. Amostras de sangue foram coletadas nos dias 0, 1, 2, 3, 4, 5, 10, 15, 20 e 28 para análises de cálcio, fósforo, ácidos graxos não esterificados (AGNEs) e β-hidroxibutirato (BHBA). Albumina, bilirrubina, colesterol total, haptoglobina e paraoxonase foram analisadas nos dias 0, 3, 5, 10, 15, 20 e 28. Foi avaliado o escore de condição corporal e a produção leiteira até 60 dias pós-parto. Níveis reduzidos de BHBA (P<0,05) foram encontrados no grupo BUT. Animais com alto IFH apresentaram menores níveis de BHBA (P<0,05) e tendência de redução nos níveis de AGNEs (P<0,10), porém o IFH não foi influenciado pelos tratamentos. Apesar de o butafosfan reduzir os níveis de BHBA, o índice de funcionalidade hepática de vacas primímaras não foi influenciado pelos tratamentos.

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“…Several factors can lead to the occurrence of this disorder, such as number of lactations, management and body condition score at calving (Nielen et al 1994;Duffield et al 2009). Several strategies have been developed to combat this condition, one of which is the use of butafosfan, a source of organic phosphorus, associated with cyanocobalamin, a variant of cobalamin (Vitamin B12) that is able to reduce fat mobilisation, as demonstrated by a reduction in levels of b-hydroxybutyrate (BHBA) and non-esterified fatty acids (NEFA), and increases the ingestion of dry matter (Pereira et al 2013).…”

Section: Introductionmentioning

confidence: 99%

“…Changes in these proteins are associated with several diseases such as uterine infections (Schneider et al 2013), reduction in conception rate (Nightingale et al 2015) and fatty liver and chronic liver damage (Bionaz et al 2007) and can therefore be used to obtain an early diagnosis of the immune status of the animal (Reis et al 2016). The association of butafofan and cyanocobalamin, favouring energy metabolism, may improve immunity in the animal by reducing NEFA levels (Pereira et al 2013).…”

Section: Introductionmentioning

confidence: 99%

Hemogasometry, metabolic profile and acute-phase proteins in primiparous Holstein cows supplemented with butafosfana associated or not of cyanocobalamin

Antunes

Londero

Pizoni

et al. 2019

Italian Journal of Animal Science

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The aim of study was to evaluate whether butafosfan, associated or not with cyanocobalamin, alters the metabolic profile, hemogasometrics and acute phase proteins in recent postpartum dairy cows. Twenty-five cows (n ¼ 25) were selected for study and divided into three groups: Butafosfan (BUT, n ¼ 9); Butafosfan þ Cyanocobalamin (BUTC, n ¼ 9); and Control (CTL, n ¼ 7). Treatments were applied daily from calving until 5 days postpartum. Blood samples for hemogasometry were performed on days 0, 1, 2 and 3, and for other metabolites on days 0, 1, 2, 3, 4, 5, 10, 15, 20 and 28 postpartum. Blood pH was lower in the BUT and BUTC groups than in the CTL group (p ¼ .03) and carbon dioxide pressure was higher in the BUT and BUTC groups compared to CTL (p ¼ .01). In addition, ionised calcium levels were higher in the BUT and BUTC groups (p ¼ .0003) in comparison to CTL, whereas the BUT group had higher levels. The BUT group had the lowest levels of paraoxonase (p ¼ .03). On the other hand, glucose levels tended to be highest in the BUT group (p ¼ .08). The butafosfan with or without cyanocobalamin increased ionised calcium levels and tended to stabilise blood pH in the early post-partum cows, and butafosfan without cyanocobalamin tended to increase blood glucose levels. HIGHLIGHTS Treated animals increase serum ionised calcium; Treated animals have a reduction in blood pH; Butafosfan tends to increase the glucose concentration.

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Metabolic parameters and dry matter intake of ewes treated with butaphosphan and cyanocobalamin in the early postpartum period

Cited by 20 publications

References 26 publications

Establishment of an analytical method for butaphosphan (BTP), a stress-attenuating agent, and its application in the preliminary pharmacokinetic evaluation of residues in olive flounder Paralichthys olivaceus

Establishment of an analytical method for butaphosphan (BTP), a stress-attenuating agent, and its application in the preliminary pharmacokinetic evaluation of residues in olive flounder Paralichthys olivaceus

Butafosfan e cianocobalamina: estratégia para melhorar a funcionalidade hepática de vacas leiteiras primíparas

Hemogasometry, metabolic profile and acute-phase proteins in primiparous Holstein cows supplemented with butafosfana associated or not of cyanocobalamin

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