Metabolic profiling identifies TC and LDL as potential serum biomarkers for depressive symptoms in schizophrenia

Fang, Xinyu; Chen, Lixian; Wang, Dandan; Li, Yu; Wang, Yewei; Chen, Yan; Ren, Jun; Tang, Wei; Zhang, Chen

doi:10.1016/j.psychres.2019.112522

Cited by 24 publications

(10 citation statements)

References 43 publications

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“…Evidence shows that the prevalence rates of depression in schizophrenia varies from 30 to 70% (8)(9)(10). The wide range difference in prevalence estimates could be attributed to cohort status, illness status (acute or chronic), and definition of depression.…”

Section: Introductionmentioning

confidence: 99%

Gender Differences of Schizophrenia Patients With and Without Depressive Symptoms in Clinical Characteristics

Liu

Fang

et al. 2022

Front. Psychiatry

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Objectives: To investigate the differences in psychotic symptoms and cognitive function in schizophrenics with and without depression and to compare gender differences in the correlation between depressive symptoms and clinical characteristics in those patients.Methods: A total of 190 schizophrenia patients and 200 healthy controls were recruited in the study. We used the Positive and Negative Symptom Scale (PANSS), the Calgary Depression Scale for Schizophrenia (CDSS) and the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) to evaluate the psychiatric symptoms, depressive symptoms and cognitive function, respectively. Patients with CDSS score ≥7 were divided into depression group, and CDSS < 7 was viewed as without depression.Results: Patients with schizophrenia had lower total scores of RBANS and five subscale (immediate memory, visual span, verbal function, attention, and delayed memory) scores compared to healthy controls. In the case group, patients who concomitant with depression had higher PANSS scores (Ps < 0.001) and lower RBANS (Ps < 0.05) scores than those without depression. After gender stratification, PANSS total scores and subscale scores were significantly different between schizophrenics with and without depressive symptoms in both male and female groups (Ps < 0.001). For cognitive function, there were significant differences in RBANS total score and subscale scores except attention between female patients with and without schizophrenia but not in male schizophrenia patients. Furthermore, the correlation analysis showed that the total CDSS score was positively correlated with PANSS score (P < 0.001) and RBANS score in male and female groups (male: P = 0.010, female: P = 0.001).Conclusion: Our findings provided evidence supporting the gender differences in psychiatric symptoms and cognitive function between schizophrenia patients with and without depressive symptoms.

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Section: Introductionmentioning

confidence: 99%

Gender Differences of Schizophrenia Patients With and Without Depressive Symptoms in Clinical Characteristics

Liu

Fang

et al. 2022

Front. Psychiatry

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“…These changes can increase the comorbidity risk of cardiovascular disease, which will undoubtedly have a negative effect on the prognosis of schizophrenia patients ( 23 ). A comparative study demonstrated that schizophrenia patients had higher levels of serum LDL, but lower levels of HDL, than health controls ( 24 ). The result mentioned above hinted that the level of lipoproteins had an effect on the tolerance to antipsychotic treatments of schizophrenia patients and then consequently affected the LOS.…”

Section: Introductionmentioning

confidence: 99%

Factors Related to the Length of Stay for Patients With Schizophrenia: A Retrospective Study

Peng

Wang

et al. 2022

Front. Psychiatry

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BackgroundThe length of stay (LOS) of patients with schizophrenia has been a wide concern of researchers. Reasonable management of the LOS to achieve a balance between quality of treatment and efficient medical source allocation has become a significant issue in clinical work in psychiatry. Figuring out the factors related to the LOS of schizophrenia patients can help optimize its management by the hospital.MethodThe essential information of patients was obtained from the electronic medical record system. The variables were divided into the following kinds: demographic, clinical, and biochemical. Univariate analysis and multivariate analysis were conducted to find the potential factors related to the LOS of schizophrenia patients. Receiver operating characteristic analyses were conducted to evaluate the accuracy of judging the LOS of the regression model.ResultA total of 1,160 patients with schizophrenia were enrolled in our research. Our results demonstrated that the status of unmarried (single, separated, divorced, or widowed) and the abnormality of thyroid-stimulating hormone (TSH) were risk factors for the longer LOS of schizophrenia patients. The area under the curve was 0.576, which meant that the regression model had a certain predictive value.ConclusionTo our knowledge, this research is the first study to analyze the effect of various factors, including the biochemical index, on the LOS of a single type of mental disorder. Marital status and TSH were proven to be related to the LOS of schizophrenia patients. The results of this study provided reference factors of LOS for clinical psychiatry, which will be helpful to the management of hospitalization and in optimizing the allocation of medical sources.

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“…com/ get/ Scien ce-CAD/G-Power. shtml) was used to run a power calculation and determine the effect size [45].…”

Section: Discussionmentioning

confidence: 99%

“…After comparing the differences in various indicators between the two subgroups, the variables with differences ( P < 0.05) between the two subgroups were finally included (the duration of disease, NEF, TESL, concept formation, structure and memory) in the stepwise logistical regression analysis to explore the independent risk factor for DS. The G*Power 3.1.9.2 program ( http://www.softpedia.com/get/Science-CAD/G-Power.shtml ) was used to run a power calculation and determine the effect size [ 45 ].…”

Section: Methodsmentioning

confidence: 99%

Eye movement characteristics in male patients with deficit and non-deficit schizophrenia and their relationships with psychiatric symptoms and cognitive function

Zhang

Fang

et al. 2021

BMC Neurosci

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Background The cognitive impairment pattern of deficit schizophrenia (DS) is centered on an impaired attention function. Previous studies have suggested that the exploratory eye movement (EEM) tests reflect attention deficits in patients with schizophrenia. However, no study has investigated the characteristics of eye movement in DS in the Chinese Han population. This study aimed to investigate the pattern of eye movement characteristics in DS patients and to examine whether eye movement characteristic is associated with serious negative symptoms and cognitive decline in this schizophrenia subtype. Methods A total of 86 male patients [37 DS and 49 non-deficit schizophrenia (NDS)] and 80 healthy controls (HC) participated in this study. Clinical symptoms were assessed using the Scale for the Assessment of Positive Symptoms (SAPS) and Scale for the Assessment of Negative Symptoms (SANS). Cognitive function was assessed using the Mattis Dementia Rating Scale (MDRS-2). Eye movement data of subjects were collected using an eye movement tracking analyzer. Results There were significant differences in the overall eye movement data and cognitive test scores among the three groups (all P < 0.001). Both DS and NDS schizophrenia subgroups showed more severe eye movement and cognitive impairment compared with the control group. The number of eye fixations (NEF), total of eye scanning length (TESL), and cognitive function in DS patients were significantly lower than those in NDS patients. The discriminant analysis (D score) was higher than that of the control group (P < 0.001). In the DS group, the inattention factor of SANS was negatively correlated with the attention factor (r = − 0.545, P = 0.001) and structure factor of cognitive (r = − 0.389, P = 0.023), the affective flattening factor of SANS was negatively correlated with TESL (r = − 0.353, P = 0.041) and initiation/retention factor of cognitive (r = − 0.376,P = 0.028). TESL was found to positively correlate with the MDRS-2 total score (r = 0.427, P = 0.012), attention factor (r = 0.354, P = 0.040), and memory factor (r = 0.349, P = 0.043) in the DS group, whereas the mean of eye scanning length (MESL) positively correlated with cognitive impairments in the NDS group. The negative symptoms showed no significant correlation with cognition in the NDS group. Conclusions Total of eye scanning length may be a characteristic eye movement symptom in DS patients, which is associated with serious negative symptoms and cognitive impairment in this schizophrenia subtype.

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Metabolic profiling identifies TC and LDL as potential serum biomarkers for depressive symptoms in schizophrenia

Cited by 24 publications

References 43 publications

Gender Differences of Schizophrenia Patients With and Without Depressive Symptoms in Clinical Characteristics

Gender Differences of Schizophrenia Patients With and Without Depressive Symptoms in Clinical Characteristics

Factors Related to the Length of Stay for Patients With Schizophrenia: A Retrospective Study

Eye movement characteristics in male patients with deficit and non-deficit schizophrenia and their relationships with psychiatric symptoms and cognitive function

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