Metabolic profiling on the analysis of different parts of Schisandra chinensis based on UPLC-QTOF-MS with comparative bioactivity assays

Liu, Jiushi; Mu, Xinlu; Liang, Jinmei; Zhang, Jianuo; Qiang, Tingyan; Li, Hongbo; Li, Bin; Liu, Haitao; Zhang, Bengang

doi:10.3389/fpls.2022.970535

Cited by 7 publications

(3 citation statements)

References 40 publications

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“…The S. chinensis fruit contains the highest amount of lignans, accounting for approximately 2% of its dry weight ( 44 ). A comparative study was conducted on the amount of lignan in S. chinensis extracts of fruit, leaves, stems, and roots using ultra performance liquid chromatography (UPLC)-Q-TOF-MS ( 45 ). The researchers found that the roots contained higher contents of gomisin D, schisandrol B, schisanterin C, kadsuranin, and kadlongilactone F than those in the fruits, and these components were closely related to their antioxidant and anti-inflammatory activities ( 45 ).…”

Section: Nutritional and Active Components Of Schisandra Ch...mentioning

confidence: 99%

“…A comparative study was conducted on the amount of lignan in S. chinensis extracts of fruit, leaves, stems, and roots using ultra performance liquid chromatography (UPLC)-Q-TOF-MS ( 45 ). The researchers found that the roots contained higher contents of gomisin D, schisandrol B, schisanterin C, kadsuranin, and kadlongilactone F than those in the fruits, and these components were closely related to their antioxidant and anti-inflammatory activities ( 45 ). The antioxidant capacity of the main lignans in S. chinensis extract was determined by using the HPLC-online TEAC method.…”

Section: Nutritional and Active Components Of Schisandra Ch...mentioning

confidence: 99%

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An analysis of the nutritional effects of Schisandra chinensis components based on mass spectrometry technology

Jia¹,

Li²,

Lou³

et al. 2023

Front. Nutr.

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ObjectiveSchisandra chinensis (Turcz.) Baill. (S. chinensis) is a Traditional Chinese medicinal herb that can be used both for medicinal purposes and as a food ingredient due to its beneficial properties, and it is enriched with a wide of natural plant nutrients, including flavonoids, phenolic acids, anthocyanins, lignans, triterpenes, organic acids, and sugars. At present, there is lack of comprehensive study or systemic characterization of nutritional and active ingredients of S. chinensis using innovative mass spectrometry techniques.MethodsThe comprehensive review was conducted by searching the PubMed databases for relevant literature of various mass spectrometry techniques employed in the analysis of nutritional components in S. chinensis, as well as their main nutritional effects. The literature search covered the past 5 years until March 15, 2023.ResultsThe potential nutritional effects of S. chinensis are discussed, including its ability to enhance immunity, function as an antioxidant, anti-allergen, antidepressant, and anti-anxiety agent, as well as its ability to act as a sedative-hypnotic and improve memory, cognitive function, and metabolic imbalances. Meanwhile, the use of advanced mass spectrometry detection technologies have the potential to enable the discovery of new nutritional components of S. chinensis, and to verify the effects of different extraction methods on these components. The contents of anthocyanins, lignans, organic acids, and polysaccharides, the main nutritional components in S. chinensis, are also closely associated to its quality.ConclusionThis review will provide guidelines for an in-depth study on the nutritional value of S. chinensis and for the development of healthy food products with effective components.

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Section: Nutritional and Active Components Of Schisandra Ch...mentioning

confidence: 99%

Section: Nutritional and Active Components Of Schisandra Ch...mentioning

confidence: 99%

An analysis of the nutritional effects of Schisandra chinensis components based on mass spectrometry technology

Jia¹,

Li²,

Lou³

et al. 2023

Front. Nutr.

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“…Increasing modern research shows Schisandra extracts may help protect liver cells from injury and inflammation, enhance detoxification capacity, improve tissue regeneration, and slow progression of fibrosis. These beneficial mechanisms make Schisandra chinensis a promising herbal medicine for further research on chronic liver therapies [15].…”

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confidence: 99%

Schisandra chinensis in Liver Disease: Exploring the Mechanisms and Therapeutic Promise of an Ancient Chinese Botanical

Addissouky,

El Sayed,

Ali

et al. 2024

Arch Pharmacol Ther

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Background: Schisandra chinensis is a traditional Chinese herbal medicine that has been used for centuries for liver health. The active lignans in Schisandra, including schisandrin and gomisins, have exhibited anti-inflammatory, antioxidant, and hepatoprotective properties in preliminary studies. With rising rates of chronic liver diseases globally, there is interest in the potential therapeutic role of Schisandra. Purpose: To comprehensively review the current evidence for Schisandra chinensis in treating liver injury and disease and synthesize implications for future human research. Main body: Schisandra extracts decreased inflammatory cytokines and oxidative stress markers and increased endogenous antioxidant activity in animal models, suggesting utility in mitigating liver inflammation and damage. Additional preclinical studies demonstrated attenuated liver enzyme levels, necrosis, and fibrosis progression in chemical-induced hepatotoxicity with Schisandra treatment. Enhanced cytochrome P450 activity, glutathione production, and glycogen synthesis were also observed, improving detoxification and regeneration capacity. Small human trials in hepatitis and nonalcoholic fatty liver disease showed improved liver enzymes and symptoms with Schisandra supplementation but were limited in quality and sample size. Conclusion: Schisandra chinensis has biologically relevant mechanisms that warrant further human research on its role as a hepatoprotective phytotherapy. Well-designed, large-scale clinical trials are needed to establish efficacy and safety for liver disease applications.

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Physiological and molecular mechanisms of radicle development of somatic embryos in Schisandra chinensis cultured in the dark

Sun,

Zhang,

et al. 2024

Plant Cell Tiss Organ Cult

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Somatic embryogenesis (SE) is a method for producing plant embryos in vitro and is considered a highly promising approach for micropropagation. As a valuable Chinese herbal medicine, the application of SE in genetic breeding, such as in Schisandra chinensis, faces several technical challenges, including incomplete development of somatic embryos and di culties in plant regeneration. Here, we established an e cient plant regeneration pathway for somatic embryos in S. chinensis. In this experiment, dark culture conditions were found to signi cantly improve the plant regeneration rooting rate through SE. To understand the genetic mechanism governing embryogenesis, a comparative transcriptome analysis was performed to elucidate differences between light and dark conditions on somatic embryo development in S. chinensis. Dormant buds of S. chinensis were used as explants, and embryonic calli were cultured in light (16 h/D) or dark conditions for 28 days. The cultivation of explants in darkness has been shown to signi cantly enhance the production of somatic embryo radicles. Under dark conditions, radicle primordia were initiated at the globular embryo stage and developed from the heart-shaped to the torpedo-shaped embryo stages. To explore the S. chinensis root mechanism, endogenous hormones were quanti ed, and RNA-seq analysis was performed throughout the process of somatic embryogenesis. The results indicated that from the globular to heart-shaped embryo stages, the levels of IAA and ABA in somatic embryos subjected to the dark treatment were markedly lower (190.965 ng•g − 1 and 525.152 ng•g − 1 ) than those in somatic embryos exposed to light (597.565 ng•g − 1 and 749.188 ng•g − 1 ), while the concentrations of GA 3 and ZR were lower at all stages under light treatment.Transcriptome sequencing and bioinformatics analysis revealed that the pathways and processes in which the differentially expressed genes in somatic embryos under dark conditions were predominantly enriched were plant hormone signaling, circadian rhythm, and phenylpropanoid biosynthesis. qRT-PCR was employed to validate the expression of plant hormone signaling transduction-related genes, including GH3, SAUR, ARF1, ARF18, AUX/IAA, MMK1, AHK4, AHK5, and PIF3, and the results were consistent with the transcriptome sequencing results. This work laid the foundation for applied research and could be useful in future reluctant woody plant improvement programs and can even be extended to other species. Key MessageDark culture signi cantly improved the radicle development of somatic embryos in S. chinensis and the differentially expressed genes were predominantly enriched in plant hormone signals, which corresponded to endogenous hormone levels. 34. Zhou XM (2008) Study on somatic embryogenesis of tree peony. Beijing Forestry University

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Metabolic profiling on the analysis of different parts of Schisandra chinensis based on UPLC-QTOF-MS with comparative bioactivity assays

Cited by 7 publications

References 40 publications

An analysis of the nutritional effects of Schisandra chinensis components based on mass spectrometry technology

An analysis of the nutritional effects of Schisandra chinensis components based on mass spectrometry technology

Schisandra chinensis in Liver Disease: Exploring the Mechanisms and Therapeutic Promise of an Ancient Chinese Botanical

Physiological and molecular mechanisms of radicle development of somatic embryos in Schisandra chinensis cultured in the dark

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