Metabolic reprogramming in cervical cancer and metabolomics perspectives

Abstract

Cumulative studies have shown that metabolic reprogramming is a hallmark of malignant tumors. The emergence of technological advances, such as omics studies, has strongly contributed to the knowledge of cancer metabolism. Cervical cancer is among the most common cancers in women worldwide. Because cervical cancer is a virus-associated cancer and can exist in a precancerous state for years, investigations targeting the metabolic phenotypes of cervical cancer will enhance our understanding of the interference of viruses on host cells and the progression of cervical carcinogenesis. The purpose of this review was to illustrate metabolic perturbations in cervical cancer, the role that human papillomavirus (HPV) plays in remodeling cervical cell metabolism and recent approaches toward application of metabolomics in cervical disease research. Cervical cancer displays typical cancer metabolic profiles, including glycolytic switching, high lactate levels, lipid accumulation and abnormal kynurenine/tryptophan levels. HPV, at least in part, contributes to these alterations. Furthermore, emerging metabolomics data provide global information on the metabolic traits of cervical diseases and may aid in the discovery of biomarkers for diagnosis and therapy.

Interactions between microbiota and cervical epithelial, immune, and mucus barrier

“…Cytokine and protein concentration were also different collected by endocervical swabs, lavage samples, and vaginal swabs (Dezzutti et al, 2011). Third, sequencing method, laboratory and data processing differ across studies, such as DNA extraction, sequencing target, platform, and annotation database may also impact the sequencing, metabolome and proteome result (Theodoridis et al, 2012;Schnaars et al, 2018;Mattei et al, 2019;Li and Sui, 2021;Sirichoat et al, 2021). For instance, the richness and diversity of cervical microbiota increased in HR-HPV positive women compared with healthy control by 16S rRNA sequencing, however, the difference were not obvious in metagenomic sequencing (Fang et al, 2022).…”

Differential Effect of Non-Purified and Semi-Purified Standard Diets on Kynurenine and Peripheral Metabolites in Male C57BL/6J Mice

“…Dysregulation of the KP has been reported not only in males but also in females. 34 Therefore, it is necessary to elucidate the effects of diets on the KP in female mice. Moreover, we did not analyze critical metabolites, such as QUIN and KA, in the brain KP.…”

Plasma‐Based Metabolomics Profiling of High‐Risk Human Papillomavirus and their Emerging Roles in the Progression of Cervical Cancer

“…Metabolites, as indicators are valuable for identifying biomarkers of cervical cancer. Studies have reported that in the study of metabonomics about cervical cancer, samples were blood (serum or plasma), vaginal secretions, tissues, and urine [ 34 ]. A study reported that combination of lysophosphatidylcholine (17 : 0), n-oleoyl threonine, bilirubin, tetracosahexaenoic acid (lysoPC(17 : 0)), and 12-hydroxydodecanoic acidare are satisfactory candidate biomarkers for cervical cancer diagnosis from cervical cancer plasma samples [ 35 ].…”