Metabolic reprogramming in skin wound healing

Wang, Zitong; Zhao, Feng; Xu, Chengcheng; Zhang, Qiqi; Ren, Haiyue; Huang, Xing; He, Cai; Ma, Jiajie; Wang, Zhe

doi:10.1093/burnst/tkad047

Cited by 18 publications

(3 citation statements)

References 130 publications

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“…Metabolic reprogramming, a hallmark of cancer cells ( Pavlova et al, 2022 ), involves altering cellular metabolism to manage different inputs and stressors ( Wang et al, 2024 ). Cancer cells adapt their metabolic pathways to oncogenic mutations and external nutritional conditions, supporting their increased biosynthetic and energy needs while mitigating oxidative stress associated with survival and proliferation ( Altea-Manzano et al, 2020 ; McGuirk et al, 2020 ; Schiliro and Firestein, 2021 ).…”

Section: The Per Gene Family and Metabolismmentioning

confidence: 99%

Biological clock regulation by the PER gene family: a new perspective on tumor development

Chen,

Wang,

et al. 2024

Front. Cell Dev. Biol.

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The Period (PER) gene family is one of the core components of the circadian clock, with substantial correlations between the PER genes and cancers identified in extensive researches. Abnormal mutations in PER genes can influence cell function, metabolic activity, immunity, and therapy responses, thereby promoting the initiation and development of cancers. This ultimately results in unequal cancers progression and prognosis in patients. This leads to variable cancer progression and prognosis among patients. In-depth studies on the interactions between the PER genes and cancers can reveal novel strategies for cancer detection and treatment. In this review, we aim to provide a comprehensive overview of the latest research on the role of the PER gene family in cancer.

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Section: The Per Gene Family and Metabolismmentioning

confidence: 99%

Biological clock regulation by the PER gene family: a new perspective on tumor development

Chen,

Wang,

et al. 2024

Front. Cell Dev. Biol.

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“…Macrophage polarization is closely linked to metabolic reprogramming, with distinct metabolic profiles associated with M1 and M2 phenotypes. 5 , 224 , 225 M1 macrophages rely on glycolysis and the pentose phosphate pathway to meet their energy demands and support their proinflammatory functions. 226 In contrast, M2 macrophages primarily utilize oxidative phosphorylation and fatty acid oxidation for energy production.…”

Section: Signaling Pathways Orchestrating Macrophage Polarization: An...mentioning

confidence: 99%

Macrophage plasticity: signaling pathways, tissue repair, and regeneration

Yan,

Wang,

Cai

et al. 2024

MedComm

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Macrophages are versatile immune cells with remarkable plasticity, enabling them to adapt to diverse tissue microenvironments and perform various functions. Traditionally categorized into classically activated (M1) and alternatively activated (M2) phenotypes, recent advances have revealed a spectrum of macrophage activation states that extend beyond this dichotomy. The complex interplay of signaling pathways, transcriptional regulators, and epigenetic modifications orchestrates macrophage polarization, allowing them to respond to various stimuli dynamically. Here, we provide a comprehensive overview of the signaling cascades governing macrophage plasticity, focusing on the roles of Toll‐like receptors, signal transducer and activator of transcription proteins, nuclear receptors, and microRNAs. We also discuss the emerging concepts of macrophage metabolic reprogramming and trained immunity, contributing to their functional adaptability. Macrophage plasticity plays a pivotal role in tissue repair and regeneration, with macrophages coordinating inflammation, angiogenesis, and matrix remodeling to restore tissue homeostasis. By harnessing the potential of macrophage plasticity, novel therapeutic strategies targeting macrophage polarization could be developed for various diseases, including chronic wounds, fibrotic disorders, and inflammatory conditions. Ultimately, a deeper understanding of the molecular mechanisms underpinning macrophage plasticity will pave the way for innovative regenerative medicine and tissue engineering approaches.

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“…11 Skin wound healing involves metabolic reprogramming of glucose, lipids, amino acids and other nutrients that play a vital role in the proliferation, differentiation and migration of various cell types. 12 The mechanisms of development of disorders of reparative regeneration are not fully understood. There is insufficient information about the features of changes in the basic indicators of metabolic processes during the healing of chronic wounds.…”

Section: Introductionmentioning

confidence: 99%

Features of metabolism in chronic wound remodelling

Pavlov,

Babenko,

Kumetchko

et al. 2024

Scripta Medica

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Background/Aim: The treatment of chronic wounds continues to be a pressing problem throughout the world. Healing occurs through some evolutionarily conserved biochemical pathways. The mechanisms of development of disorders of reparative regeneration are not fully understood. The work aimed to study the dynamics of changes in metabolic parameters during the healing of chronic wounds. Methods: Healthy Wistar rats were divided into two groups. The animals of the first group were intact. Chronic wounds were simulated for the animals of the second group. On days 7, 14 and 28 after wound creation, the animals were euthanised. Biochemical parameters such as glucose, total protein, albumin, cholesterol, urea, creatinine, aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP) were assessed in the blood serum of animals. Results: It was found that the maximum decrease in glucose and total protein levels in the blood serum of animals in the experimental groups compared to intact animals was observed 2 weeks after surgery: the glucose concentration in rats was 1.7 times lower (p < 0.001). The level of albumin in the blood serum of experimental animals compared to intact animals was reduced by 1.5 times after 14 days (p < 0.001) and by 1.2 times after 28 days (p < 0.01). A week after surgery, the concentration of urea in the blood serum of experimental animals was 1.3 times higher (p < 0.01) than in intact rats and by day 28 after surgery, the urea level was 1.4 times higher (p < 0.001). The reduction in cholesterol and creatinine levels was not significant. An increase in AST, AST and ALP levels in the blood serum of experimental animals was shown. An increase in the blood serum of animals 7 days after surgery compared to the indicators of intact animals: ALP concentrations by 2.8 times (p < 0.001) and ALT concentrations by 1.4 times (p < 0.001) was established. The AST level significantly increased 14 days after surgery (p < 0.05). Conclusions: The study of metabolic parameters allows monitoring of the state of the body during the healing process of wounds to correct treatment tactics.

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Metabolic reprogramming in skin wound healing

Cited by 18 publications

References 130 publications

Biological clock regulation by the PER gene family: a new perspective on tumor development

Biological clock regulation by the PER gene family: a new perspective on tumor development

Macrophage plasticity: signaling pathways, tissue repair, and regeneration

Features of metabolism in chronic wound remodelling

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