Metabolic Reprogramming is a Hallmark of Metabolism Itself

Medina, Miguel Ángel

doi:10.1002/bies.202000058

Cited by 14 publications

(14 citation statements)

References 166 publications

(169 reference statements)

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“…Metabolic reprogramming is a crucial area of study in cancer and is listed as a hallmark of cancer [ 1 ]. Dr. Otto Warburg first described metabolic reprogramming while studying the properties of tumorigenic cells.…”

Section: Introductionmentioning

confidence: 99%

Hallmarks of Metabolic Reprogramming and Their Role in Viral Pathogenesis

Allen

Arjona

Santerre

et al. 2022

Viruses

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Metabolic reprogramming is a hallmark of cancer and has proven to be critical in viral infections. Metabolic reprogramming provides the cell with energy and biomass for large-scale biosynthesis. Based on studies of the cellular changes that contribute to metabolic reprogramming, seven main hallmarks can be identified: (1) increased glycolysis and lactic acid, (2) increased glutaminolysis, (3) increased pentose phosphate pathway, (4) mitochondrial changes, (5) increased lipid metabolism, (6) changes in amino acid metabolism, and (7) changes in other biosynthetic and bioenergetic pathways. Viruses depend on metabolic reprogramming to increase biomass to fuel viral genome replication and production of new virions. Viruses take advantage of the non-metabolic effects of metabolic reprogramming, creating an anti-apoptotic environment and evading the immune system. Other non-metabolic effects can negatively affect cellular function. Understanding the role metabolic reprogramming plays in viral pathogenesis may provide better therapeutic targets for antivirals.

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Section: Introductionmentioning

confidence: 99%

Hallmarks of Metabolic Reprogramming and Their Role in Viral Pathogenesis

Allen

Arjona

Santerre

et al. 2022

Viruses

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“…This poses, however, a first semantic problem, which is to involuntarily give cancer cells an anthropomorphic behavior-a cell able to modify its own code by itself for a specific purpose. This perhaps contributes to the encouragement of the community to focus on the study of tumors at the genetic/epigenetic level at the expense of other levels of molecular interactions, although that tends to change with the rise of new omics [36]. Trans-omics [40], in particular, could be encouraged in the future in order to integrate these different levels of interactions.…”

Section: Discussionmentioning

confidence: 99%

“…Finally, it may be necessary to reintegrate the capacity for the cell to transit within this metabolic landscape, adopting several of these states depending on environmental conditions, by considering its metabolic adaptability, i.e., the set of molecular mechanisms achievable by the cell with or without mutation that allow it to survive in its environment. Can we finally think of the metabolism in a less genocentric manner [36] to include, as the opposite, all of its levels of complexity in a more holistic framework?…”

Section: Discussionmentioning

confidence: 99%

“…We are faced with intricate mechanisms that influence each other, and all are potential candidates to be the final "trigger" of cancer. It has been suggested that "metabolic reprogramming" could be a hallmark of metabolism itself and not specific to cancer cells [36]. If metabolic adaptive capacity is inherent in all cells, the specificity of tumor cells might lie in the enhanced ability to do so (by over-expressing potentially pre-existing processes) [13].…”

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confidence: 99%

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Metabolic Reprogramming, Questioning, and Implications for Cancer

Jacquet

Stéphanou

2021

Biology

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The expression “metabolic reprogramming” has been encountered more and more in the literature since the mid-1990s. It seems to encompass several notions depending on the author, but the lack of a clear definition allows it to be used as a “catch-all” expression. Our first intention is to point out the inconsistencies in the use of the reprogramming terminology for cancer metabolism. The second is to address the over-focus of the role of mutations in metabolic adaptation. With the increased interest in metabolism and, more specifically, in the Warburg effect in cancer research, it seems appropriate to discuss this terminology and related concepts in detail.

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“…But capturing the aggregate effect of the maize root physiology on biomass production under Nis essential to understand plant-wide reprogramming of its metabolism. This sort of reprogramming has been reported as the hallmark of metabolism which allows any system to adapt to the changes to external conditions (Medina, 2020). Thus, in order to capture this metabolic reprogramming of maize root under Nin an integrated manner, developing system biology approaches will allow to have a dynamic picture of plant adaptation to nitrogen deficiency.…”

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confidence: 99%

Dissecting the Metabolic Reprogramming of Maize Root under Nitrogen Limiting Stress Condition

Chowdhury

Schroeder

Sarkar

et al. 2021

Preprint

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The growth and development of maize (Zea mays L.) largely depends on its nutrient uptake through root. Hence, studying its growth, response, and associated metabolic reprogramming to stress conditions is becoming an important research direction. A genome-scale metabolic model (GSM) for the maize root was developed to study its metabolic reprogramming under nitrogen-stress condition. The model was reconstructed based on the available information from KEGG, UniProt, and MaizeCyc. Transcriptomics data derived from the roots of hydroponically grown maize plants was used to incorporate regulatory constraints in the model and simulate nitrogen-non-limiting (N−) and nitrogen-deficient (N−) conditions. Model-predicted result achieved 70% accuracy comparing to the experimental direction change of metabolite levels. In addition to predicting important metabolic reprogramming in central carbon, fatty acid, amino acid, and other secondary metabolism, maize root GSM predicted several metabolites (e.g., L-methionine, L-asparagine, L-lysine, cholesterol, and L-pipecolate) playing critical regulatory role in the root biomass growth. Furthermore, this study revealed eight phosphatidyl-choline and phosphatidyl-glycerol metabolites which even though not coupled with biomass production played a key role in the increased biomass production under N-. Overall, the omics-integrated-GSM provides a promising tool to facilitate stress-condition analysis for maize root and ultimately engineer better stress-tolerant maize genotypes.SummaryThe growth and development of maize (Zea mays L.) largely depends on its nutrient uptake through root. Hence, studying its growth, response, and associated metabolic reprogramming to stress conditions is becoming an important research direction.A genome-scale metabolic model (GSM) for the maize root was developed to study its metabolic reprogramming under nitrogen-stress condition. The model was reconstructed based on the available information from KEGG, UniProt, and MaizeCyc.Transcriptomics data derived from the roots of hydroponically grown maize plants was used to incorporate regulatory constraints in the model and simulate nitrogen-non-limiting (N+) and nitrogen-deficient (N−) conditions. Model-predicted result achieved 70% accuracy comparing to the experimental direction change of metabolite levels. In addition to predicting important metabolic reprogramming in central carbon, fatty acid, amino acid, and other secondary metabolism, maize root GSM predicted several metabolites (e.g., L-methionine, L-asparagine, L-lysine, cholesterol, and L-pipecolate) playing critical regulatory role in the root biomass growth. Furthermore, this study revealed eight phosphatidyl-choline and phosphatidyl-glycerol metabolites which even though not coupled with biomass production played a key role in the increased biomass production under N−.Overall, the omics-integrated-GSM provides a promising tool to facilitate stress-condition analysis for maize root and ultimately engineer better stress-tolerant maize genotypes.

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Metabolic Reprogramming is a Hallmark of Metabolism Itself

Cited by 14 publications

References 166 publications

Hallmarks of Metabolic Reprogramming and Their Role in Viral Pathogenesis

Hallmarks of Metabolic Reprogramming and Their Role in Viral Pathogenesis

Metabolic Reprogramming, Questioning, and Implications for Cancer

Dissecting the Metabolic Reprogramming of Maize Root under Nitrogen Limiting Stress Condition

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