Metabolic studies with model cytochrome p-450 systems

Biomimetic Chemical Catalysts in the Oxidative Activation of Drugs

“…[16,29] products identical to those obtained from in vivo metabolism ( Figure 4C). [22] This Mn(TPP)Cl/PhIO system also oxidizes KRP-197, a dual antagonist of the muscarinic acetylcholine receptors M 1 and M 3 , to give a mono-oxidized product at position 5 of the imidazole ring (which is the putative precursor of the main metabolites), giving an example of application of these biomimetic systems to the in vitro metabolic studies of heterocyclic drugs ( Figure 5A). [23] The Mn(TPP)Cl/NaOCl system was used to couple phenolic benzylisoquinoline alkaloids.…”

“…Examples of C-oxidation reactions. [18,19,21,22] (IBPP) to afford side-chain-and heterocycle-hydroxylated products ( Figure 5B). [30,32] The Fe(TPFPP)X/PhIO system can decarboxylate non-steroidal and anti-inflammatory drugs belonging to the family of arylacetic and arylpropionic acids to give the corresponding alcohol and carbonyl derivatives ( Figures 6C and 7A, B).…”