Metabolic syndrome; Definition, Pathogenesis, Elements, and the Effects of medicinal plants on it’s elements

Ahmed, Musaab; Kumari, Nisha; Mirgani, Zainelabdin; Saeed, Amal; Ramadan, Azza; Ahmed, Mohamed H.; Almobarak, Ahmed O.

doi:10.1007/s40200-021-00965-2

Cited by 33 publications

(18 citation statements)

References 87 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Metabolic syndrome (MetS) is a complex of cardiovascular disease and diabetes related risk factors, including hypertension, impaired fasting glucose, abdominal obesity and dyslipidemia (1)(2)(3). MetS is becoming a global problem that increasingly violates human health and quality of life, and the risk of its occurrence increases with age (4,5).…”

Section: Introductionmentioning

confidence: 99%

Association between dietary inflammatory index and metabolic syndrome: Analysis of the NHANES 2005–2016

Zhang

Guo²,

Yao³

et al. 2022

Front. Nutr.

View full text Add to dashboard Cite

ObjectiveMetabolic syndrome (MetS) is a global problem that increasingly violates human health and quality of life. We explored the relationship between dietary inflammatory potential represented by dietary inflammatory index (DII) and the occurrence of MetS to provid data support for the prevention of it through dietary structure intervention.MethodsThe data was come from National Health and Nutrition Examination Survey 2007–2018, including demographic, dietary, questionnaire variables and laboratory indicators. MetS was defined according to the criteria proposed by the American Endocrine Association (ACE) and the American Society of Clinical Endocrinology (ACCE). DII was calculated using the scoring method established by Shivappa. We divided DII scores into 4 quartiles, the chi-square test was used to compare the variable difference between DII quartiles groups. A logistic regression model was used to analyze the association between DII and MetS. We also performed subgroup analysis. A generalized linear regression model was used to explore the association of DII level and the levels of seven MetS related biochemical indicators.ResultsThe final sample size was 8,180, and the DII scores of the subjects were −5.50 to 5.22. The proportions of men, young people, non-Hispanic blacks, poor people, smokers, and MetS patients in the Q1–Q4 DII quantiles groups were gradually increased. The risk of MetS in the Q4 group which had highest dietary inflammatory degree was 1.592 (1.248, 2.030) times higher than that in the Q1 group, respectively (P < 0.001). After subgroup analysis, women, youth, non-smokers and alcohol drinkers were found to be more sensitive to the dietary inflammation. Then we found that the level of DII was significantly positively correlated with waist circumference (WC), body mass index (BMI), triglyceride (TG), systolic blood pressure (SBP) and diastolic blood pressure (DBP), but negatively correlated with high density lipoprotein cholesterol (HDL-C).ConclusionsIn the research subjects, the degree of dietary inflammation was associated with the occurrence of MetS and significantly affected WC, BMI, blood pressure, and blood lipid levels. It is necessary to conduct investigations and early dietary interventions for women and young people to prevent the occurrence of chronic metabolic diseases.

show abstract

Section: Introductionmentioning

confidence: 99%

Association between dietary inflammatory index and metabolic syndrome: Analysis of the NHANES 2005–2016

Zhang

Guo²,

Yao³

et al. 2022

Front. Nutr.

View full text Add to dashboard Cite

show abstract

“…Age, obesity, and inactivity increase blood pressure, blood glucose, blood triglycerides and cholesterol, and body fat levels. Although the definition of metabolic syndrome differs between groups, the excessive accumulation of lipids in visceral adipose tissue combined with hypertension, hyperglycemia, or hyperlipidemia can be defined as metabolic syndrome [ 1 , 2 , 3 ]. Patients with metabolic syndrome exhibit a high prevalence of cardiovascular disease and stroke [ 4 , 5 ], both of which are major causes of death [ 5 , 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

Ubiquitin-Specific Proteases (USPs) and Metabolic Disorders

Kitamura

2023

IJMS

View full text Add to dashboard Cite

Ubiquitination and deubiquitination are reversible processes that modify the characteristics of target proteins, including stability, intracellular localization, and enzymatic activity. Ubiquitin-specific proteases (USPs) constitute the largest deubiquitinating enzyme family. To date, accumulating evidence indicates that several USPs positively and negatively affect metabolic diseases. USP22 in pancreatic β-cells, USP2 in adipose tissue macrophages, USP9X, 20, and 33 in myocytes, USP4, 7, 10, and 18 in hepatocytes, and USP2 in hypothalamus improve hyperglycemia, whereas USP19 in adipocytes, USP21 in myocytes, and USP2, 14, and 20 in hepatocytes promote hyperglycemia. In contrast, USP1, 5, 9X, 14, 15, 22, 36, and 48 modulate the progression of diabetic nephropathy, neuropathy, and/or retinopathy. USP4, 10, and 18 in hepatocytes ameliorates non-alcoholic fatty liver disease (NAFLD), while hepatic USP2, 11, 14, 19, and 20 exacerbate it. The roles of USP7 and 22 in hepatic disorders are controversial. USP9X, 14, 17, and 20 in vascular cells are postulated to be determinants of atherosclerosis. Moreover, mutations in the Usp8 and Usp48 loci in pituitary tumors cause Cushing syndrome. This review summarizes the current knowledge about the modulatory roles of USPs in energy metabolic disorders.

show abstract

“…Metabolic syndrome (MetS) refers to a cluster of metabolic disorders which involve central obesity, insulin resistance, high blood pressure, and dyslipidemia (9)(10)(11). Pathophysiologically, MetS is characterized by insulin resistance and systemic low-degree inflammation, which have been both related to carcinogenesis (12).…”

Section: Introductionmentioning

confidence: 99%

Metabolic syndrome and survival of patients with hepatocellular carcinoma: A meta-analysis

2023

View full text Add to dashboard Cite

BackgroundMetabolic syndrome (MetS) has been related to a high incidence of hepatocellular carcinoma (HCC). However, the influence of MetS on survival of patients with HCC is still unclear. We performed a systematic review and meta-analysis to evaluate the association between MetS and survival of HCC patients.MethodsA search of PubMed, Embase, and Web of Science retrieved relevant cohort studies from the inception of the databases to October 16, 2022. Data collection, literature search, and statistical analysis were carried out independently by two authors. We pooled the results using a random-effects model that incorporates heterogeneity.ResultsIn the meta-analysis, 8080 patients with HCC were included from ten cohort studies, and 1166 patients (14.4%) had MetS. Eight studies included patients treated primarily with radical hepatectomy, one study with patients receiving sorafenib, and another study included patients who were treated with radical hepatectomy or non-surgical treatments. Pooled results showed that MetS was associated with poor overall survival (OS, risk ratio [RR]: 1.21, 95% confidence interval [CI]:1.08 to 1.37, p = 0.001; I2 = 32%) and progression-free survival (PFS, RR: 1.33, 95% CI: 1.18 to 1.49, p < 0.001, I2 = 14%). Influencing analysis by excluding one study at a time showed consistent results (p all < 0.05). Subgroup analyses showed similar results in studies with MetS diagnosed with the National Cholesterol Education Program Adult Treatment Panel III or International Diabetes Federal criteria, and in studies with mean follow-up durations < or ≥ 3.5 years (p for subgroup difference all > 0.05).ConclusionIn patients with HCC, MetS may be a risk factor of poor OS and PFS, particularly for those after radical hepatectomy.

show abstract

Metabolic syndrome; Definition, Pathogenesis, Elements, and the Effects of medicinal plants on it’s elements

Cited by 33 publications

References 87 publications

Association between dietary inflammatory index and metabolic syndrome: Analysis of the NHANES 2005–2016

Association between dietary inflammatory index and metabolic syndrome: Analysis of the NHANES 2005–2016

Ubiquitin-Specific Proteases (USPs) and Metabolic Disorders

Metabolic syndrome and survival of patients with hepatocellular carcinoma: A meta-analysis

Contact Info

Product

Resources

About