Metabolic syndrome in a sample of drug-naive Egyptian patients with psychotic disorders

Effat, S.; Elsamei, Afaf Mohamed Abd El; Ghonemy, Soheir; Roushdy, Tamer

doi:10.1097/01.xme.0000407822.53401.30

Cited by 2 publications

(10 citation statements)

References 37 publications

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“…After the removal of duplicates, 2473 abstracts and titles were screened. At the full-text stage, 112 were screened, 18 articles were included in a systematic review, 13 (De Hert et al, 2008;Effat et al, 2012;Enez Darcin, Yalcin Cavus, Dilbaz, Kaya, & Dogan, 2015;Garcia-Rizo et al, 2017;Grover, Nebhinani, Chakrabarti, Parakh, & Ghormode, 2012;Kraemer et al, 2011;Martín Otaño, Barbadillo Izquierdo, Galdeano Mondragón, Alonso Pinedo, & Querejeta Ayerdi, 2013;Medved, Kuzman, Jovanovic, Grubisin, & Kuzman, 2009;Owiredu, Osei, Amidu, Appiah-Poku, & Osei, 2012;Saddicha, Ameen, & Akhtar, 2007;Sahpolat & Ari, 2021;Saloojee, Burns, & Motala, 2018;Srivastava, Bhatia, & Sharma, 2018) articles were included in the main statistical analyses (prevalence of MetS in drug naïve, 0 days of antipsychotic medication) (Fig. 1) and an additional five studies that included up to 47 days were considered for the supplementary sensitivity analysis (see below).…”

Section: Search Resultsmentioning

confidence: 99%

“…2). Some studies did not fall within the pooled prevalence estimate (Effat et al, 2012;Enez Darcin et al, 2015;Owiredu et al, 2012). Three studies reported a high prevalence of 40% (Effat et al, 2012), 32% (Enez Darcin et al, 2015) and 31.5% (Sahpolat & Ari, 2021).…”

Section: Pooled Mets Prevalencementioning

confidence: 89%

“…Some studies did not fall within the pooled prevalence estimate (Effat et al, 2012;Enez Darcin et al, 2015;Owiredu et al, 2012). Three studies reported a high prevalence of 40% (Effat et al, 2012), 32% (Enez Darcin et al, 2015) and 31.5% (Sahpolat & Ari, 2021). The study visually furthest from the pooled prevalence estimate (k = 1, n = 20) (Effat et al, 2012) considered 'naïve' as either never treated (0-day exposure) or drug-free for at least 6 months before the commencement of the study (Table 1).…”

Section: Pooled Mets Prevalencementioning

confidence: 99%

“…S1 online supplemental) showed there is no evidence of publication bias, so no trim and fill adjustment was Psychological Medicine needed ( p = 0.4507). Only four studies reported the prevalence of MetS among women (Effat et al, 2012;Garcia-Rizo et al, 2017;Grover et al, 2012;Medved et al, 2009). The total cases of MetS among women were 19 out of 173.…”

Section: Pooled Mets Prevalencementioning

confidence: 99%

“…S2). One study (Effat et al, 2012) may be an outlier based on visual inspection. However, when excluding it from the analysis, the overall prevalence estimate just changed from 13.2% (95% CI 8.7-19.5) to 12% (95% CI 8-18).…”

Section: Other Sensitivity and Subgroup Analysismentioning

confidence: 99%

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Metabolic syndrome in antipsychotic-naïve patients with first-episode psychosis: a systematic review and meta-analysis

et al. 2021

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Background It is unclear what the prevalence of metabolic syndrome (MetS) in drug-naïve first-episode of psychosis (FEP) is, as previous meta-analyses were conducted in minimally exposed or drug-naïve FEP patients with psychotic disorder at any stage of the disease; thus, a meta-analysis examining MetS in naïve FEP compared with the general population is needed. Methods Studies on individuals with FEP defined as drug-naïve (0 days exposure to antipsychotics) were included to conduct a systematic review. A meta-analysis of proportions for the prevalence of MetS in antipsychotic-naïve patients was performed. Prevalence estimates and 95% CI were calculated using a random-effect model. Subgroup analyses and meta-regressions to identify sources and the amount of heterogeneity were also conducted. Results The search yielded 4143 articles. After the removal of duplicates, 2473 abstracts and titles were screened. At the full-text stage, 112 were screened, 18 articles were included in a systematic review and 13 articles in the main statistical analysis. The prevalence of MetS in naïve (0 days) FEP is 13.2% (95% CI 8.7–19.0). Ethnicity accounted for 3% of the heterogeneity between studies, and diagnostic criteria used for MetS accounted for 7%. When compared with controls matched by sex and age, the odds ratio is 2.52 (95% CI 1.29–5.07; p = 0.007). Conclusions Our findings of increased rates of MetS in naïve FEP patients suggest that we are underestimating cardiovascular risk in this population, especially in those of non-Caucasian origin. Our findings support that altered metabolic parameters in FEPs are not exclusively due to antipsychotic treatments.

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Section: Search Resultsmentioning

confidence: 99%

Section: Pooled Mets Prevalencementioning

confidence: 89%

Section: Pooled Mets Prevalencementioning

confidence: 99%

Section: Pooled Mets Prevalencementioning

confidence: 99%

Section: Other Sensitivity and Subgroup Analysismentioning

confidence: 99%

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Metabolic syndrome in antipsychotic-naïve patients with first-episode psychosis: a systematic review and meta-analysis

et al. 2021

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Post-stroke depression: frequency, risk factors, and impact on quality of life among 103 stroke patients—hospital-based study

Khedr

Abdel‐Rahman

Desoky

et al. 2020

Egypt J Neurol Psychiatry Neurosurg

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Background Post-stroke depression (PSD) has worse functional outcomes and quality of life. Despite the extensive literature on this topic, there is no agreement on the frequency or risk factors for post-stroke depression. Objectives To establish the frequency and risk factors of post-stroke depression and its impact on quality of life. Patients and methods One hundred three stroke patients were recruited from the out-patient clinic of Qena University Hospital who satisfied the WHO definition for stroke, together with a control group of 50 age- and sex-matched healthy volunteers. A complete history, neurological examination, and CT brain were obtained for each patient. DSM-IV TR criteria were used for diagnosis of depressive disorders which was scored with the Hamilton depression rating scale (HAM-D); Barthel Index (BI), and quality of life were also measured. Results Thirty-eight (36.9%) stroke patients had PSD which was significantly higher than in the normal population (control group 12%). Statistically significant risk factors for PSD included low educational level, low socioeconomic status, smoking, and post-stroke functional impairment. Post-stroke depression has an impact on quality of life. Conclusion Post-stroke depression is a relatively common complication of stroke and can affect the quality of life. Low educational level and socioeconomic status, as well as smoking and functional impairments, were considered as risk factors for the occurrence of post-stroke depression. Early detection of predictors of post-stroke depression may improve the outcome of stroke and prevent the psychiatric consequences.

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Metabolic syndrome in a sample of drug-naive Egyptian patients with psychotic disorders

Cited by 2 publications

References 37 publications

Metabolic syndrome in antipsychotic-naïve patients with first-episode psychosis: a systematic review and meta-analysis

Metabolic syndrome in antipsychotic-naïve patients with first-episode psychosis: a systematic review and meta-analysis

Post-stroke depression: frequency, risk factors, and impact on quality of life among 103 stroke patients—hospital-based study

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