Metabolic syndrome is associated with change in subclinical arterial stiffness - A community-based Taichung Community Health Study

Abstract

BackgroundThe aim of this study was to evaluate the effect of MetS on arterial stiffness in a longitudinal study.MethodsBrachial-ankle pulse wave velocity (baPWV), a measurement interpreted as arterial stiffness, was measured in 1518 community-dwelling persons at baseline and re-examined within a mean follow-up period of 3 years. Multivariate linear regression with generalized estimating equations (GEE) were used to examine the longitudinal relationship between MetS and its individual components and baPWV, while multivariate logistic regression with GEE was used to examine the longitudinal relationship between MetS and its individual components and the high risk group with arterial stiffness.ResultsSubjects with MetS showed significantly greater baPWV at the end point than those without MetS, after adjusting for age, gender, education, hypertension medication and mean arterial pressure (MAP). MetS was associated with the top quartile of baPWV (the high-risk group of arterial stiffness, adjusted odds ratio [95% confidence interval] 1.52 [1.21-1.90]), and a significant linear trend of risk for the number of components of MetS was found (p for trend < 0.05). In further considering the individual MetS component, elevated blood pressure and fasting glucose significantly predicted a high risk of arterial stiffness (adjusted OR [95% CI] 3.72 [2.81-4.93] and 1.35 [1.08-1.68], respectively).ConclusionsMetS affects the subject's progression to arterial stiffness. Arterial stiffness increased as the number of MetS components increased. Management of MetS is important for preventing the progression to advanced arterial stiffness.

Gender-Specific Association Between the Metabolic Syndrome and Arterial Stiffness in 8,300 Subjects

“…regression model (ENTER method). Elevated baPWV (1, no; 2, yes), determined according to the age-stratified and sex-stratified normal reference values, 12 and abnormalities of the MetS components (1, no; 2, yes) were used as dummy variables. Data were analyzed using the SPSS statistical software, version 17.0 (SPSS Inc, Chicago, IL), with the exception of the KruskalWallis test and the Dunn's post hoc analysis, which was performed using the GraphPad Prism software, version 5.0 (GraphPad Software Inc, San Diego, CA).…”

“…Studies have shown that baPWV is greater in subjects with MetS than those without it. 11,12 In addition, the cardiovascular morbidity associated with MetS is greater in women than in men. It is likely that women with MetS develop greater atherosclerosis; however, this is not yet definitive.…”

Metabolic syndrome and its risk factors among middle aged population of Iran, a population based study

“…In both Western and Asian populations, cardiovascular morbidity and mortality is 2-5 times higher in those who are suffering from this syndrome than those who are not affected by MS [8]. The prevalence of MS has been reported in various countries differently.…”

Relationship between brachial-ankle pulse wave velocity and metabolic syndrome components in a Chinese population

“…It was found that subjects with MS had significantly greater baPWV at the endpoint than those without MS, after adjusting for age, gender, education, hypertension medication and mean arterial pressure. Arterial stiffness increased as the number of MS components increased[24]. Zhu et al enrolled a total of 5,476 subjects from annual health checkups and demonstrated that the values of baPWV and its change rates in MS patients were both higher than those in non-MS subjects.…”