Metabolism and excretion of orally and intraperitoneally administered methylarsonic acid in the hamster

Yamauchi, Hiroshi; Yamato, Naohisa; Yamamura, Yukio

doi:10.1007/bf01881052

Cited by 30 publications

(39 citation statements)

References 15 publications

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“…The time to peak concentration of MMA(V)-derived radioactivity in blood (1-4 h) of mice was slightly earlier than that observed in hamsters (27 mg As/kg) (6 h), sheep (10 mg As/kg) (5 h) and goats (10 mg As/kg) (5 h) treated similarly (Shariatpanahi and Anderson, 1984;Yamauchi et al, 1988). In humans, MMA(V) (500 μg As) was also rapidly absorbed, based on the percentage of the dose (46%) recovered in urine 4 h after oral administration (Buchet et al, 1981).…”

Section: Discussionmentioning

confidence: 77%

“…After ip administration of MMA(V) (27 mg As/ kg) in hamsters, 80% of the dose was excreted in urine by 24 h, whereas fecal excretion was 1% (Yamauchi et al, 1988). In contrast, 56% of a po dose of MMA(V) (27 mg/kg) in hamsters was excreted in feces by 24 h (Yamauchi et al, 1988).…”

Section: Discussionmentioning

confidence: 99%

“…In hamsters, Yamauchi et al (1988) observed lower urinary excretion (<35% of the dose) of orally administered MMA(V) (27 mg As/kg) than reported for humans (90% of 500 μg As dose) (Buchet et al, 1981), sheep (53% of 10 mg As/kg dose) and goats (50% of 10 mg As/kg dose) (Shariatpanahi and Anderson, 1984). After ip administration of MMA(V) (27 mg As/ kg) in hamsters, 80% of the dose was excreted in urine by 24 h, whereas fecal excretion was 1% (Yamauchi et al, 1988).…”

Section: Discussionmentioning

confidence: 99%

“…By comparison, hamsters appear to absorb less MMA(V) than other species. By 24 h post-dosing, 56% of a po dose (27 mg As/kg) of MMA(V) was eliminated in feces (Yamauchi et al, 1988). In contrast, biliary excretion of MMA(V) administered ip (27 mg As/ kg) to hamsters was minimal, as 78% of the administered dose was excreted in urine by 24 h (Yamauchi et al, 1988).…”

Section: Introductionmentioning

confidence: 99%

“…Less than 10% of a po administered dose of MMA(V) to humans (500 μg As) (Buchet et al, 1981) or hamsters (3-166 mg As/kg) (Yamauchi et al, 1988) or iv to mice (0.4 or 40 mg As/kg) (Hughes and Kenyon, 1998) or rats (0.2-0.25 mg/kg) Suzuki et al, 2004a) was converted to dimethylarsenic species. In vitro studies with rat liver cytosol , rat and human hepatocytes (Styblo et al, 1999) or human recombinant arsenic methyltransferase (Hayakawa et al, in press) also show that methylation of MMA(V) was minimal.…”

Section: Introductionmentioning

confidence: 99%

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Tissue dosimetry, metabolism and excretion of pentavalent and trivalent monomethylated arsenic in mice after oral administration

Hughes

Devesa

Adair

et al. 2005

Toxicology and Applied Pharmacology

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Exposure to monomethylarsonic acid (MMA(V)) and monomethylarsonous acid (MMA(III)) can result from their formation as metabolites of inorganic arsenic and by the use of the sodium salts of MMA(V) as herbicides. This study compared the disposition of MMA(V) and MMA(III) in adult female B6C3F1 mice. Mice were gavaged po with MMA(V), either unlabeled or labeled with 14 C at two dose levels (0.4 or 40 mg As/kg). Other mice were dosed po with unlabeled MMA(III) at one dose level (0.4 mg As/kg). Mice were housed in metabolism cages for collection of excreta and sacrificed serially over 24 h for collection of tissues. MMA(V)-derived radioactivity was rapidly absorbed, distributed and excreted. By 8 h post-exposure, 80% of both doses of MMA(V) were eliminated in urine and feces. Absorption of MMA(V) was dose dependent; that is, there was less than a 100-fold difference between the two dose levels in the area under the curves for the concentration-time profiles of arsenic in blood and major organs. In addition, urinary excretion of MMA(V)-derived radioactivity in the low dose group was significantly greater (P < 0.05) than in the high dose group. Conversely, fecal excretion of MMA(V)-derived radioactivity was significantly greater (P < 0.05) in the high dose group than in the low dose group. Speciation of arsenic by hydride generation-atomic absorption spectrometry in urine and tissues of mice administered MMA(V) or MMA(III) found that methylation of MMA(V) was limited while the methylation of MMA(III) was extensive. Less than 10% of the dose excreted in urine of MMA(V)-treated mice was in the form of methylated products, whereas it was greater than 90% for MMA(III)-treated mice. In MMA(V)-treated mice, 25% or less of the tissue arsenic was in the form of dimethylarsenic, whereas in MMA (III)-treated mice, 75% or more of the tissue arsenic was in the form of dimethylarsenic. Based on urinary analysis, administered dose of MMA(V) did not affect the level of its metabolites excreted. In the tested range, dose affects the absorption, distribution and route of excretion of MMA(V) but not its metabolism.

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Section: Discussionmentioning

confidence: 77%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Tissue dosimetry, metabolism and excretion of pentavalent and trivalent monomethylated arsenic in mice after oral administration

Hughes

Devesa

Adair

et al. 2005

Toxicology and Applied Pharmacology

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Arsenic compounds in terrestrial organisms. III: Arsenic compounds inFormica from an old arsenic smelter site

Kuehnelt¹,

Goessler²,

Schlagenhaufen³

et al. 1997

Appl. Organometal. Chem.

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Total arsenic concentrations in the freeze‐dried pulverized ants (Formica sp.) and material from an ant‐hill collected at a former arsenic roasting facility were determined by inductively coupled plasma mass spectrometry (ICP–MS) after microwave digestion with nitric acid and hydrogen peroxide. The ants contained 12.6±0.9 mg As/kg dry mass, the ant‐hill material 5420±90 mg As/kg dry mass. Total arsenic concentrations in needles of Picea abies and Larix decidua (spruce and larch needles) were also determined, because needles are the main constituents of the upper layer of ant‐hill material. Needles of Picea abies contained 1.17 mg As/kg dry mass and needles of Larix decidua 3.71 mg As/kg. The Formica sp. and ant‐hill material were extracted with water or methanol/water (9:1). The extracts were chromatographed on a cation‐exchange and an anion‐exchange column. Water extracted 20% of the arsenic from the ants and only 3% from the ant‐hill material. With methanol/water (9:1) only 7% of the arsenic was released by the ants and 0.5% by the ant‐hill material. The arsenic compounds in the column effluents that were introduced into the plasma via a hydraulic high‐pressure nebulizer (HHPN) were quantified on‐line by ICP–MS. Arsenite and arsenate were the major arsenic compounds in the extract. Dimethylarsinic acid and traces of methylarsonic acid and arsenobetaine were also detected. The extracts of the ant‐hill material contained the same compounds. Additionally, traces of trimethylarsine oxide were found. The presence of arsenobetaine was confirmed by spiking an extract of the ants with synthetic arsenobetaine bromide. © 1997 John Wiley & Sons, Ltd.

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Methylarsenverbindungen [MAK Value Documentation in German language, 2014]

2014

The MAK‐Collection for Occupational Health and Safety

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Metabolism and excretion of orally and intraperitoneally administered methylarsonic acid in the hamster

Cited by 30 publications

References 15 publications

Tissue dosimetry, metabolism and excretion of pentavalent and trivalent monomethylated arsenic in mice after oral administration

Tissue dosimetry, metabolism and excretion of pentavalent and trivalent monomethylated arsenic in mice after oral administration

Arsenic compounds in terrestrial organisms. III: Arsenic compounds inFormica from an old arsenic smelter site

Methylarsenverbindungen [MAK Value Documentation in German language, 2014]

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