Metabolite Alterations and Interactions with Microbiota&amp;nbsp;In  &lt;i&gt;Helicobacter pylori&lt;/i&gt; Associated Gastric Lesions

Peng, Lei; Guo, Yang; Gerhard, Markus; Gao, Juanjuan; Liu, Zongchao; Mejías-Luque, Raquel; Ma, Jian; Liu, Weidong; Li, Zhe-Xuan; Zhou, Tong; Li, Wenqing; You, Wei‐Cheng; Zhang, Yang; Pan, Kai-Feng

doi:10.2139/ssrn.4314020

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“…A combined microbiome and metabolomics study 37 was conducted using paired gastric biopsy tissues at baseline and follow‐up to investigate potential interactions between characteristic microbiota and metabolite profiles in the escalation and improvement of H. pylori ‐associated gastric lesions. The analysis revealed significant changes in metabolite profiles, including acylcarnitines, ceramides, cholesterol esters, fatty acids, sphingolipids, triacylglycerols, glycerophospholipids, and glycosylceramides, with fold changes of at least 1.5 between successful and failed treatment outcomes.…”

Section: Clinical Evidence Of the Involvement Of Helicobacter Pylori ...mentioning

confidence: 99%

“…Notably, moderate negative correlations were observed between glycosylceramides and Fusobacterium , Gemella , Porphyromonas , and Streptococcus . Incorporating this panel of metabolites and genera significantly improved the discrimination performance for active gastritis, as indicated by an area under the receiver operating characteristic (ROC) curve of 0.914, outperforming the traditional model that only considered age and gender 37 …”

Section: Clinical Evidence Of the Involvement Of Helicobacter Pylori ...mentioning

confidence: 99%

“…These ceramides are abundantly distributed in cell membrane lipid rafts and serve as important signal transducers in the initiation of inflammation 70 . Metabolic omics studies have identified several species of ceramides, such as Cer(d18:1/22:0), Cer(d18:1/24:1), Hex2Cer(d18:1/22:0), and HexCer(d18:1/24:1), which are associated with the progression of H. pylori ‐infected gastritis during a 6‐month follow‐up after eradication 37 …”

Section: Metabolic Pathways Alterationsmentioning

confidence: 99%

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Interactions between Helicobacter pylori infection and host metabolic homeostasis: A comprehensive review

Ye,

Feng,

et al. 2023

Helicobacter

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The microbiota actively and extensively participates in the regulation of human metabolism, playing a crucial role in the development of metabolic diseases. Helicobacter pylori (H. pylori), when colonizing gastric epithelial cells, not only induces local tissue inflammation or malignant transformation but also leads to systemic and partial changes in host metabolism. These shifts can be mediated through direct contact, toxic components, or indirect immune responses. Consequently, they influence various molecular metabolic events that impact nutritional status and iron absorption in the host. Unraveling the intricate and diverse molecular interaction links between H. pylori and human metabolism modulation is essential for understanding pathogenesis mechanisms and developing targeted treatments for related diseases. However, significant challenges persist in comprehensively understanding the complex association networks among H. pylori itself, the infected host's status, the host microbiome, and the immune response. Previous metabolomics research has indicated that H. pylori infection and eradication may selectively shape the metabolite and microbial profiles of gastric lesions. Yet, it remains largely unknown how these diverse metabolic pathways, including isovaleric acid, cholesterol, fatty acids, and phospholipids, specifically modulate gastric carcinogenesis or affect the host's serum metabolism, consequently leading to the development of metabolic‐associated diseases. The direct contribution of H. pylori to metabolisms still lacks conclusive evidence. In this review, we summarize recent advances in clinical evidence highlighting associations between chronic H. pylori infection and metabolic diseases, as well as its potential molecular regulatory patterns.

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Section: Clinical Evidence Of the Involvement Of Helicobacter Pylori ...mentioning

confidence: 99%

Section: Clinical Evidence Of the Involvement Of Helicobacter Pylori ...mentioning

confidence: 99%

Section: Metabolic Pathways Alterationsmentioning

confidence: 99%

See 1 more Smart Citation

Interactions between Helicobacter pylori infection and host metabolic homeostasis: A comprehensive review

Ye,

Feng,

et al. 2023

Helicobacter

View full text Add to dashboard Cite

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Metabolite Alterations and Interactions with Microbiota In <i>Helicobacter pylori</i> Associated Gastric Lesions

Cited by 1 publication

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Interactions between Helicobacter pylori infection and host metabolic homeostasis: A comprehensive review

Interactions between Helicobacter pylori infection and host metabolic homeostasis: A comprehensive review

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