Metabolite Profiling and Principle Component Analysis of a Mangrove Plant Aegiceras Corniculatum L (Blanco)

Abstract

Metabolite profiling is the multi-parallel relative quantification of a mixture of compounds or compound classes using chromatography and universal detection technologies (GC-MS, LCMS) for biological samples. Metabolic profiling could provide the link between traditional herbal medicines and molecular pharmacology. Aegiceras corniculatum is one of the important species of black river mangrove plant. Present studies explaining the strategies of metabolite profiling of polar as well as non-polar compounds from leaves and bark extracts of plant Aeiceras corniculatum by using GC-MS. The range of solvent from non-polar to polar viz. petroleum ether, chloroform, ethyl acetate, methanol and water separately used for extraction. The GC-MS profile revealed the presence of phenolics, carbohydrates, steroids, alkaloids, hydrocarbons, fatty acids and esters, amines etc. In parallel with GC-MS statistical analytical tools such as principal component analysis used to yield significant and precise results. In present study the biologically active compounds-Plectoxanxthin, Ndeacetyl Colchicine, Cyclopentaneundecanoic acid, Thiirane, Gamolenic acid, 8,11,14-Eicosatrienoic acid, Lupol, Rhodopine were reported from different extracts of plant.

Allelopathic Potential of Mangroves from the Red River Estuary against the Rice Weed Echinochloa crus-galli and Variation in Their Leaf Metabolome

“…Aegiceras corniculatum has been phytochemically investigated in several previous studies [ 37 , 67 , 68 ] and pharmacological assessments showed antimicrobial, anti-inflammatory, antioxidant and cytotoxic activities in this plant [ 41 , 69 , 70 ].…”

“…Ultra-high-performance liquid chromatography coupled with high-resolution mass spectrometry (UHPLC-HRMS) is a sensitive and powerful analytical tool that is now increasingly used for untargeted metabolomics [ 35 , 36 ]. Few studies have applied metabolomics for mangrove phytochemical description [ 37 , 38 , 39 , 40 ]. Such an analytical approach may provide valuable information for better description of plant natural products that might be involved in allelopathic activities.…”

A Review on Bioactive Phytochemical Constituents and Pharmacological Activities of Aegiceras corniculatum: A Pharmaceutically Important Mangrove Plant

“…Various studies have identifed that A. corniculatum extract contains a spectrum of naturally occurring chemical constituents, including favonoids (such as kaempferol, quercetin, and isorhamnetin), benzoquinones (such as embelin), triterpenes (including aegiceradienol, genin-A, protoprimulagenin, and aegicerin), polyphenolic acids (such as gallic acid, coumaric acid, and syringic acid), stilbenes (such as resveratrol), and other compounds which have been isolated and are believed to contribute to the diverse medicinal properties associated with diferent solvent extracts (Table 1) [27][28][29].…”

Nanophytomedicine in Clinical Management: An Introductory Evidence-based Review

“…The smaller size of nanoparticles the more easily it gets filtered, and thus the efficacy may be compromised [23]. Drugs are released from the nanoencapsulated system in a sustained manner to show chemotherapeutic activity [24], and safely gets eliminated from the bloodstream thus limiting any unexpected long-term adverse actions [25].…”