Metabolite profiling, anti-inflammatory, analgesic potentials of edible herb Colocasia gigantea and molecular docking study against COX-II enzyme

Zilani, Md. Nazmul Hasan; Islam, Aminul; Biswas, Partha; Anisuzzman,; Hossain, Hemayet; Shilpi, Jamil Ahmad; Hasan, Nazmul

doi:10.1016/j.jep.2021.114577

Cited by 25 publications

(15 citation statements)

References 38 publications

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“…Te signifcant anti-infammatory activity exhibited by the extracts of C. nioroense could be attributed to the presence of phytoconstituents such as phenols, favonoids, tannins, saponins, glycosides, terpenoids, alkaloids, and steroids [1,[51][52][53][54][55][56]. Polyphenols such as favonoids, tannins, and phenols are reported to inhibit enzymes and serve as mediators of the infammation process such as C-reactive protein or adhesion molecules [1,52,57].…”

Section: Anti-infammatory Activitymentioning

confidence: 99%

Cytotoxicity, Antimicrobial, Antioxidant, Anthelmintic, and Anti-Inflammatory Activities and FTIR Analysis of Combretum nioroense Stem Bark

Akoto

Adzimah

Forkuoh

et al. 2023

Journal of Chemistry

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Combretum nioroense is widely used in the folkloric treatment of a variety of bacterial and helminthic infections. The decoction of its leaves is traditionally fed to newborn babies in some rural parts of Ghana. The study focused on identifying the prime components of petroleum ether and ethanolic extracts of the stem bark using standard phytochemical screening protocols and chromatographic and spectroscopic techniques. The activities (cytotoxicity, antimicrobial, antioxidant, anthelmintic, and anti-inflammatory) of the extracts of C. nioroense were also investigated. Preliminary phytochemical analysis of the extracts revealed the presence of glycosides, saponins, phenols, coumarins, alkaloids, flavonoids, tannins, steroids, phytosterols, flavanols, terpenoids, and cardiac glycosides. The action of the extracts of C. nioroense on Milsonia ghanensis worms was concentration-dependent, with the least concentration (0.75 mg/mL) paralyzing and killing M. ghanensis after the maximal exposure time. The IC50 values for petroleum ether and ethanol extracts in the DPPH assay were >100.0 and 27.940 ± 1.005 μg/mL and those of the H2O2 assay were 400.900 ± 3.400 and 322.500 ± 1.005 μg/mL, respectively. The total antioxidant capacities (TACs) for petroleum ether and ethanol extracts were 47.197 ± 0.533 and 57.968 ± 0.560 gAAE/100 g, respectively. The IC50 value for ethanol extract in the cytotoxicity studies was 115.4 ± 1.332 μg/mL. The MICs of the extracts against the test organisms were within the range of 0.0122–25.0 mg/mL. The extracts (petroleum ether and ethanol) showed a concentration-dependent increase in anti-inflammatory activity with IC50 values of 31.254 ± 0.359 and 24.402 ± 0.569 μg/mL, respectively. Chromatographic separations of the ethanol extract gave three fractions. FTIR analysis of the extracts and purified fractions revealed the presence of functional groups, confirming the presence of the phytochemicals identified in the screening test. The results indicate that both extracts of C. nioroense exhibit cytotoxicity, antimicrobial, antioxidant, anthelmintic, and anti-inflammatory activities, thereby proving the folkloric use to treat ailments caused by worms and microorganisms.

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Section: Anti-infammatory Activitymentioning

confidence: 99%

Cytotoxicity, Antimicrobial, Antioxidant, Anthelmintic, and Anti-Inflammatory Activities and FTIR Analysis of Combretum nioroense Stem Bark

Akoto

Adzimah

Forkuoh

et al. 2023

Journal of Chemistry

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“…As a reaction to DNA impairment, a system of events jointly called DNA damage response (DDR) is triggered ( Figure 1 ). Such an effect involves identifying the DNA impairment, stimulating checkpoints, halting the cellular processes, and, finally, the processes of repair, apoptosis, and immune clearance ( 94 – 96 ). The building blocks of DSB-generated DDR have been analyzed and sorted into three main units: sensors to determine the impairment, transducers to organize signaling, and effectors to coordinate final events ( 97 ).…”

Section: Ros Signaling Pathway Dna Damage Response and Cancermentioning

confidence: 99%

Investigating the Anticancer Potential of Salvicine as a Modulator of Topoisomerase II and ROS Signaling Cascade

Dey

Hasan

Biswas³

et al. 2022

Front. Oncol.

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Salvicine is a new diterpenoid quinone substance from a natural source, specifically in a Chinese herb. It has powerful growth-controlling abilities against a broad range of human cancer cells in both in vitro and in vivo environments. A significant inhibitory effect of salvicine on multidrug-resistant (MDR) cells has also been discovered. Several research studies have examined the activities of salvicine on topoisomerase II (Topo II) by inducing reactive oxygen species (ROS) signaling. As opposed to the well-known Topo II toxin etoposide, salvicine mostly decreases the catalytic activity with a negligible DNA breakage effect, as revealed by several enzymatic experiments. Interestingly, salvicine dramatically reduces lung metastatic formation in the MDA-MB-435 orthotopic lung cancer cell line. Recent investigations have established that salvicine is a new non-intercalative Topo II toxin by interacting with the ATPase domains, increasing DNA–Topo II interaction, and suppressing DNA relegation and ATP hydrolysis. In addition, investigations have revealed that salvicine-induced ROS play a critical role in the anticancer-mediated signaling pathway, involving Topo II suppression, DNA damage, overcoming multidrug resistance, and tumor cell adhesion suppression, among other things. In the current study, we demonstrate the role of salvicine in regulating the ROS signaling pathway and the DNA damage response (DDR) in suppressing the progression of cancer cells. We depict the mechanism of action of salvicine in suppressing the DNA–Topo II complex through ROS induction along with a brief discussion of the anticancer perspective of salvicine.

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“…Hence, p53 mediated diverse signal transduction networks engaged in the cell’s defense against cancer. Notably, intrinsic and extrinsic stress signals affecting cellular homeostatic mechanisms may activate the p53 -directed pathway/s [ 3 , 4 ]. Conversely, p53 can induce apoptosis, prime DNA repair, or a DNA replication mechanism by following in a transcription-independent manner [ 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

Study of MDM2 as Prognostic Biomarker in Brain-LGG Cancer and Bioactive Phytochemicals Inhibit the p53-MDM2 Pathway: A Computational Drug Development Approach

Biswas¹,

Bibi

Yousafi

et al. 2023

Molecules

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An evaluation of the expression and predictive significance of the MDM2 gene in brain lower-grade glioma (LGG) cancer was carried out using onco-informatics pipelines. Several transcriptome servers were used to measure the differential expression of the targeted MDM2 gene and search mutations and copy number variations. GENT2, Gene Expression Profiling Interactive Analysis, Onco-Lnc, and PrognoScan were used to figure out the survival rate of LGG cancer patients. The protein–protein interaction networks between MDM2 gene and its co-expressed genes were constructed by Gene-MANIA tool. Identified bioactive phytochemicals were evaluated through molecular docking using Schrödinger Suite Software, with the MDM2 (PDB ID: 1RV1) target. Protein–ligand interactions were observed with key residues of the macromolecular target. A molecular dynamics simulation of the novel bioactive compounds with the targeted protein was performed. Phytochemicals targeting MDM2 protein, such as Taxifolin and (-)-Epicatechin, have been shown with more highly stable results as compared to the control drug, and hence, concluded that phytochemicals with bioactive potential might be alternative therapeutic options for the management of LGG patients. Our once informatics-based designed pipeline has indicated that the MDM2 gene may have been a predictive biomarker for LGG cancer and selected phytochemicals possessed outstanding interaction results within the macromolecular target’s active site after utilizing in silico approaches. In vitro and in vivo experiments are recommended to confirm these outcomes.

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Metabolite profiling, anti-inflammatory, analgesic potentials of edible herb Colocasia gigantea and molecular docking study against COX-II enzyme

Cited by 25 publications

References 38 publications

Cytotoxicity, Antimicrobial, Antioxidant, Anthelmintic, and Anti-Inflammatory Activities and FTIR Analysis of Combretum nioroense Stem Bark

Cytotoxicity, Antimicrobial, Antioxidant, Anthelmintic, and Anti-Inflammatory Activities and FTIR Analysis of Combretum nioroense Stem Bark

Investigating the Anticancer Potential of Salvicine as a Modulator of Topoisomerase II and ROS Signaling Cascade

Study of MDM2 as Prognostic Biomarker in Brain-LGG Cancer and Bioactive Phytochemicals Inhibit the p53-MDM2 Pathway: A Computational Drug Development Approach

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