Metabolites as predictive biomarkers for Trypanosoma cruzi exposure in triatomine bugs

Eberhard, Fanny E.; Klimpel, Sven; Guarneri, Alessandra A.; Tobias, Nicholas J.

doi:10.1016/j.csbj.2021.05.027

Cited by 8 publications

(5 citation statements)

References 49 publications

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“…For instance, some metabolites play a significant role in interspecies crosstalk [8]. In the context of Chagas disease (CD), metabolites play a key role in parasite-vector interactions, parasite-mammalian host interactions, and parasite-microbiome interactions [11]. Exogenous metabolites, such as those derived from the diet, can also influence disease progression.…”

Section: Small Molecules Metabolites and Metabolomicsmentioning

confidence: 99%

“…Additional relevant metagenome-supported metabolic capabilities include carbohydrate and nucleotide metabolism [21], which may likewise help address T. cruzi auxotrophies and energy needs. Indeed, triatomine guts and feces contain a diverse range of chemical classes, with lipids the most abundant [11,27]. Free fatty acids are an important energy source for T. cruzi epimastigotes, if glucose is limiting, and are sufficient to induce T. cruzi development from epimastigotes to metacyclic trypomastigotes [28][29][30].…”

Section: The Triatomine Vector and Metabolites: Four-way Interactions...mentioning

confidence: 99%

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Small molecule mediators of host-T. cruzi-environment interactions in Chagas disease

Kwakye-Nuako,

Middleton,

McCall

2024

PLoS Pathog

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Small molecules (less than 1,500 Da) include major biological signals that mediate host-pathogen-microbiome communication. They also include key intermediates of metabolism and critical cellular building blocks. Pathogens present with unique nutritional needs that restrict pathogen colonization or promote tissue damage. In parallel, parts of host metabolism are responsive to immune signaling and regulated by immune cascades. These interactions can trigger both adaptive and maladaptive metabolic changes in the host, with microbiome-derived signals also contributing to disease progression. In turn, targeting pathogen metabolic needs or maladaptive host metabolic changes is an important strategy to develop new treatments for infectious diseases. Trypanosoma cruzi is a single-celled eukaryotic pathogen and the causative agent of Chagas disease, a neglected tropical disease associated with cardiac and intestinal dysfunction. Here, we discuss the role of small molecules during T. cruzi infection in its vector and in the mammalian host. We integrate these findings to build a theoretical interpretation of how maladaptive metabolic changes drive Chagas disease and extrapolate on how these findings can guide drug development.

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Section: Small Molecules Metabolites and Metabolomicsmentioning

confidence: 99%

Section: The Triatomine Vector and Metabolites: Four-way Interactions...mentioning

confidence: 99%

Small molecule mediators of host-T. cruzi-environment interactions in Chagas disease

Kwakye-Nuako,

Middleton,

McCall

2024

PLoS Pathog

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“…Chagas disease is a zoonotic parasitic disease caused mainly by T. cruzi (Eberhard et al, 2022). Its main vector is bloodfeeding triatomine bugs (Eberhard et al, 2021). In recent years, with the effective control of these vectors, other transmission methods, such as oral transmission, organ transplantation and blood transfusion, have gradually attracted attention.…”

Section: Phylum Sarcomastigophora Class Zoomastigophorea 21 Chagas Di...mentioning

confidence: 99%

The state of the art of extracellular vesicle research in protozoan infection

2022

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Protozoan diseases seriously affect the health of human beings, livestock and poultry and lead to high economic and medical costs. Extracellular vesicles (EVs) are membranous structures formed through biological processes that play important roles in immune regulation. Studies have shown that parasites transmit information to hosts through EVs to modulate host immune responses. The major roles played by EVs released from parasites involve facilitating parasitization of the host. In this review, we discuss relevant recently obtained data on EVs secreted by different kinds of protozoa, including their molecular mechanisms, and discuss the roles played by EVs in the occurrence and development of parasitic diseases.

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“…This disease is transmitted by Haematophagous Triatomines of the family Reduviidae , subfamily Triatominae . To detect differences in the intestinal metabolome of the triatomine Rhodnius prolixus and predict whether the insect had been exposed to T. cruzi , Eberhard et al, 2021 [ 24 ] used logistic regression, random forest (Breiman 2001 [ 4 ]) classifiers, and gradient boosting (Friedman 2001 [ 25 ]) algorithms . Results show that the ensemble approaches outperformed logistic regression for detecting complex interactions between triatomine vectors and parasites.…”

Section: Contact-based Zoonosesmentioning

confidence: 99%

Artificial Intelligence Models for Zoonotic Pathogens: A Survey

2022

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Zoonotic diseases or zoonoses are infections due to the natural transmission of pathogens between species (animals and humans). More than 70% of emerging infectious diseases are attributed to animal origin. Artificial Intelligence (AI) models have been used for studying zoonotic pathogens and the factors that contribute to their spread. The aim of this literature survey is to synthesize and analyze machine learning, and deep learning approaches applied to study zoonotic diseases to understand predictive models to help researchers identify the risk factors, and develop mitigation strategies. Based on our survey findings, machine learning and deep learning are commonly used for the prediction of both foodborne and zoonotic pathogens as well as the factors associated with the presence of the pathogens.

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Metabolites as predictive biomarkers for Trypanosoma cruzi exposure in triatomine bugs

Abstract: Graphical abstract

Cited by 8 publications

References 49 publications

Small molecule mediators of host-T. cruzi-environment interactions in Chagas disease

Small molecule mediators of host-T. cruzi-environment interactions in Chagas disease

The state of the art of extracellular vesicle research in protozoan infection

Artificial Intelligence Models for Zoonotic Pathogens: A Survey

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