Metabolomic and metallomic profile differences between Veterans and Civilians with Pulmonary Sarcoidosis

Banoei, Mohammad Mehdi; Iupe, Isabella; Bazaz, Reza Dowlatabadi; Campos, Michael; Vogel, Hans J.; Winston, Brent W.; Mirsaeidi, Mehdi

doi:10.1038/s41598-019-56174-8

Cited by 14 publications

(11 citation statements)

References 57 publications

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“…1 H nuclear magnetic resonance (NMR)-based metabolomic analysis identified metabolites and metabolic pathways that can discriminate sarcoidosis patients from healthy ones. Acetoacetate, 3-hydroxybutyrate, carnitine, cystine, and trimethylamine N-oxide levels are significantly increased in sarcoidosis, with dysregulation of ketone bodies and citric cycle metabolism also being identified as hallmarks of this disease [173,174].…”

Section: Biomarkers For Sarcoidosismentioning

confidence: 99%

Sarcoidosis: Causes, Diagnosis, Clinical Features, and Treatments

Jain

Yadav

Puranik

et al. 2020

JCM

126

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Sarcoidosis is a multisystem granulomatous disease with nonspecific clinical manifestations that commonly affects the pulmonary system and other organs including the eyes, skin, liver, spleen, and lymph nodes. Sarcoidosis usually presents with persistent dry cough, eye and skin manifestations, weight loss, fatigue, night sweats, and erythema nodosum. Sarcoidosis is not influenced by sex or age, although it is more common in adults (< 50 years) of African-American or Scandinavians decent. Diagnosis can be difficult because of nonspecific symptoms and can only be verified following histopathological examination. Various factors, including infection, genetic predisposition, and environmental factors, are involved in the pathology of sarcoidosis. Exposures to insecticides, herbicides, bioaerosols, and agricultural employment are also associated with an increased risk for sarcoidosis. Due to its unknown etiology, early diagnosis and detection are difficult; however, the advent of advanced technologies, such as endobronchial ultrasound-guided biopsy, high-resolution computed tomography, magnetic resonance imaging, and 18F-fluorodeoxyglucose positron emission tomography has improved our ability to reliably diagnose this condition and accurately forecast its prognosis. This review discusses the causes and clinical features of sarcoidosis, and the improvements made in its prognosis, therapeutic management, and the recent discovery of potential biomarkers associated with the diagnostic assay used for sarcoidosis confirmation.

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Section: Biomarkers For Sarcoidosismentioning

confidence: 99%

Sarcoidosis: Causes, Diagnosis, Clinical Features, and Treatments

Jain

Yadav

Puranik

et al. 2020

JCM

126

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Section: Metabolomicsmentioning

confidence: 95%

“…Military veterans are exposed to several inorganic materials including gun smoke, jet fuel, asbestos, lead, and dust storms which can be accompanied by the presence of silica, aluminum, and trace elements, including zirconium, strontium, and rubidium. The authors observed that metabolomic and metallomic profiles indeed differed between the two sarcoidosis groups, suggesting that pathophysiological mechanisms and pathways differ among sarcoidosis patients with different agents triggering the disease [43].…”

Section: Lessons Learned From Chronic Beryllium Disease and Silicosismentioning

confidence: 99%

“…Besides genetic variants and epigenetics, also metabolomics and biochemical pathways may differ among sarcoidosis patients with possible different antigenic triggers. In a study of Banoei et al , [43] a group of 13 military veteran sarcoidosis patients and 30 civilian sarcoidosis patients were compared regarding plasma metabolomic and metallomic profiles. Military veterans are exposed to several inorganic materials including gun smoke, jet fuel, asbestos, lead, and dust storms which can be accompanied by the presence of silica, aluminum, and trace elements, including zirconium, strontium, and rubidium.…”

Section: Lessons Learned From Chronic Beryllium Disease and Silicosismentioning

confidence: 99%

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The emerging role of inorganic elements as potential antigens in sarcoidosis

Beijer

Veltkamp

2021

Current Opinion in Pulmonary Medicine

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Purpose of reviewPrevious studies mainly described a role for organic agents as possible triggers for sarcoidosis. In this review, we address recent studies suggesting a possible role for inorganic elements, such as metals or silica in sarcoidosis pathogenesis.Recent findingsSeveral epidemiological papers suggest that inorganic agents, either by environmental exposures or occupational activities, could trigger sarcoidosis. Association between inorganics and sarcoidosis is also described in several recently published case reports and studies demonstrating immunological sensitization to inorganic agents in sarcoidosis patients.Studies comparing chronic beryllium disease (CBD) and sarcoidosis suggest that although antigenic triggers may differ, underlying processes may be comparable.Besides the fact that a growing number of studies show a possible role for inorganic triggers, it is also suggested that inorganic triggered sarcoidosis may result in a more severe phenotype, including pulmonary fibrosis.SummaryWe can use the knowledge already gained on CBD pathogenesis to conduct further research into role of inorganics, such as metals and silica as antigens in sarcoidosis. Given the importance of a lymphocyte proliferation test (LPT) in diagnosing CBD, it seems obvious to also implement this test in the diagnostic work-up of sarcoidosis to identify patients with an inorganic antigenic trigger of their disease.

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“…Here, the sample size was calculated with the prevalence of NIHL in the factory (p = 0.20), the odds ratio of noise exposure in different groups (1.2), the type I error (ɑ = 0.05) and the type II error (ß = 0.20), and the case/control ratio (1:1). For the determination of the sample size, we also referred to the designs of similar studies (Banoei et al, 2019;Wang et al, 2020;Rothman et al, 2021). All workers were required to receive health examinations and hearing tests every 6 months.…”

Section: Subjects Sample Preparation and Metabolite Identificationmentioning

confidence: 99%

Plasma metabolomics analyses highlight the multifaceted effects of noise exposure and the diagnostic power of dysregulated metabolites for noise-induced hearing loss in steel workers

Zhang

Cui

et al. 2022

Front. Mol. Biosci.

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Noise exposure can lead to various kinds of disorders. Noise-induced hearing loss (NIHL) is one of the leading disorders confusing the noise-exposed workers. It is essential to identify NIHL markers for its early diagnosis and new therapeutic targets for its treatment. In this study, a total of 90 plasma samples from 60 noise-exposed steel factory male workers (the noise group) with (NIHL group, n = 30) and without NIHL (non-NIHL group, n = 30) and 30 male controls without noise exposure (control group) were collected. Untargeted human plasma metabolomic profiles were determined with HPLC-MS/MS. The levels of the metabolites in the samples were normalized to total peak intensity, and the processed data were subjected to multivariate data analysis. The Wilcoxon test and orthogonal partial least square-discriminant analysis (OPLS-DA) were performed. With the threshold of p < 0.05 and the variable importance of projection (VIP) value >1, 469 differential plasma metabolites associated with noise exposure (DMs-NE) were identified, and their associated 58 KEGG pathways were indicated. In total, 33 differential metabolites associated with NIHL (DMs-NIHL) and their associated 12 KEGG pathways were identified. There were six common pathways associated with both noise exposure and NIHL. Through multiple comparisons, seven metabolites were shown to be dysregulated in the NIHL group compared with the other two groups. Through LASSO regression analysis, two risk models were constructed for NIHL status predication which could discriminate NIHL from non-NIHL workers with the area under the curve (AUC) values of 0.840 and 0.872, respectively, indicating their efficiency in NIHL diagnosis. To validate the results of the metabolomics, cochlear gene expression comparisons between susceptible and resistant mice in the GSE8342 dataset from Gene Expression Omnibus (GEO) were performed. The immune response and cell death-related processes were highlighted for their close relations with noise exposure, indicating their critical roles in noise-induced disorders. We concluded that there was a significant difference between the metabolite’s profiles between NIHL cases and non-NIHL individuals. Noise exposure could lead to dysregulations of a variety of biological pathways, especially immune response and cell death-related processes. Our results might provide new clues for noise exposure studies and NIHL diagnosis.

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Metabolomic and metallomic profile differences between Veterans and Civilians with Pulmonary Sarcoidosis

Cited by 14 publications

References 57 publications

Sarcoidosis: Causes, Diagnosis, Clinical Features, and Treatments

Sarcoidosis: Causes, Diagnosis, Clinical Features, and Treatments

The emerging role of inorganic elements as potential antigens in sarcoidosis

Plasma metabolomics analyses highlight the multifaceted effects of noise exposure and the diagnostic power of dysregulated metabolites for noise-induced hearing loss in steel workers

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