Metabolomics as a potential tool for monitoring patients with aneurysmal subarachnoid hemorrhage

Abstract

Metabolomics has evolved into a particularly useful tool to study interactions between metabolites and serves as an aid in unraveling the complexity of entire metabolomes. Nonetheless, it is increasingly viewed as a methodology with practical applications in the clinical setting, where identifying and quantifying biomarkers of interest could prove useful for diagnostics. Starting from a concise overview of the most prominent analytical techniques employed in metabolomics, herein we present a review of its application in studies of brain metabolism and cerebrovascular diseases, paying most attention to its uses in researching aneurysmal subarachnoid hemorrhage. Both animal models and human studies are considered, and metabolites identified as potential biomarkers are highlighted.

Taurine ameliorates sensorimotor function by inhibiting apoptosis and activating A2 astrocytes in mice after subarachnoid hemorrhage

“…This initial pathogenic factor leads to secondary brain injury and the associated metabolic changes after SAH (Chen et al 2022 ). Therefore, metabolomic alterations after SAH may elucidate the pathophysiological processes that occur after SAH, and studies targeting metabolites after SAH may provide new approaches for treating secondary brain injury after SAH (Lasica et al 2022 ).…”

Transcriptomics and metabolomics reveal hypothalamic metabolic characteristics and key genes after subarachnoid hemorrhage in rats

“…The current review showed that metabolomics well describes the biochemical changes in post-hemorrhage CSF, with the ability to detect ischemic markers such as lactate, pyruvate, glucose, and glutamate (Ho et al 2023 ). Detection of changes in energy-supplying molecules in CSF after SAH can visualize the suffering of neural and glial cell damage and strongly suggest a prognosis (Lasica et al 2023 ).…”